The Morphology and Structure of Viruses

Ruigrok, Rob W.H.; Schoehn, Guy; Conway, James F.

doi:10.1002/9780470688618.taw0211

Cited by 1 publication

(1 citation statement)

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“…size of the retrovirus particle is roughly 100 nm in diameter, the size of the virions is not highly homogenous but rather varies over a fairly wide range, suggesting that a discrete, highly ordered structure may not exist. Also, it was mentioned by Ruigrok et al [23] that no intact virus or capsid structure has been determined because of a lack of defined symmetry. These reported data are consistent with the criteria of the pretended virus in the present work.…”

Section: Discussionmentioning

confidence: 97%

HCV has Transforming Potential to Retrovirus: An Ultrastructure Hypothesis

Mansy

Abdelfatah

Hassanein

2009

Ultrastructural Pathology

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The present work highlights intracellular viral morphogenesis and virus-host cell interactions in patients proved to be infected with HCV. The material of this study consisted of 28 liver biopsies taken from patients positive for serum HCV-RNA by polymerase chain reaction. Liver biopsies were processed for light and electron microscopic examination. Ultrastructural findings of this work supported a new hypothesis for the turnover of HCV to retrovirus and described the presumed involved mechanism. This novel perception offers important insights that can explain the vague mechanisms of HCV behavior in the infected hepatocytes.

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Section: Discussionmentioning

confidence: 97%