2007
DOI: 10.1016/j.molonc.2007.02.004
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The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression

Abstract: 3D cell cultures are rapidly becoming the method of choice for the physiologically relevant modeling of many aspects of non-malignant and malignant cell behavior ex vivo. Nevertheless, only a limited number of distinct cell types have been evaluated in this assay to date. Here we report the first large scale comparison of the transcriptional profiles and 3D cell culture phenotypes of a substantial panel of human breast cancer cell lines. Each cell line adopts a colony morphology of one of four main classes in … Show more

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Cited by 877 publications
(969 citation statements)
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References 58 publications
(86 reference statements)
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“…14 Morphology on BME also has been used to define specific stages of breast cancer progression based on behaviors, such as acinar structure formation, cell polarization, colony formation, proliferation, and invasion in 3D culture. [38][39][40] The implementation of 3D coculture models is currently in its infancy but shows great promise for the future. Threedimensional coculture models incorporate additional cell types with cancer cells within a physiological environment to better recapitulate the cancer cell niche.…”
Section: Cell Morphology Growth and Coculturementioning
confidence: 99%
“…14 Morphology on BME also has been used to define specific stages of breast cancer progression based on behaviors, such as acinar structure formation, cell polarization, colony formation, proliferation, and invasion in 3D culture. [38][39][40] The implementation of 3D coculture models is currently in its infancy but shows great promise for the future. Threedimensional coculture models incorporate additional cell types with cancer cells within a physiological environment to better recapitulate the cancer cell niche.…”
Section: Cell Morphology Growth and Coculturementioning
confidence: 99%
“…We set out to explore ECM‐mediated regulation of expression of the lncRNA HOTAIR in Claudin‐low breast cancer cells using lrECM 3D culture (Kenny et al ., 2007b; Prat et al ., 2010). We chose Claudin‐low MDA‐MB‐231 and Hs578T cells because of their invasive and metastatic competence (Neve et al ., 2006; Prat et al ., 2010).…”
Section: Resultsmentioning
confidence: 99%
“…Stellate morphology of both cell lines featured irregular cell clusters and projections formed by chains of cells that intersected occasionally as described elsewhere (Fig. 1C, indicated by red arrowheads) (Kenny et al ., 2007b). …”
Section: Resultsmentioning
confidence: 99%
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