The morphological organization and ultrastructure of elastin in the arterial wall of trout (Salmo gairdneri) and salmon (Salmo salar)

Serafini‐Fracassini, A.; Field, Jacqueline; Spina, Michel; Garbisa, Spiridione; Stuart, R. J.

doi:10.1016/s0022-5320(78)90016-3

Cited by 36 publications

(30 citation statements)

References 18 publications

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“…In rainbow trout, the elastin:collagen ratio is about 14 (Serafini-Fracassini et al, 1978), compared with 1.5 in mammalian proximal aorta (McDonald, 1974). The higher the elastin:collagen ratio, the more compliant is the structure.…”

Section: Discussionmentioning

confidence: 99%

“…The bulbus is composed primarily of elastin, with estimates of the actual amount of elastin within the bulbus ranging from 70% in salmonids (Serafini-Fracassini et al, 1978) to 90% in carp (Licht and Harris, 1973). In rainbow trout, the elastin:collagen ratio is about 14 (Serafini-Fracassini et al, 1978), compared with 1.5 in mammalian proximal aorta (McDonald, 1974).…”

Section: Discussionmentioning

confidence: 99%

“…Elastin-associated microfibrils are extremely rare in teleost arteries (Isokawa et al, 1990), and teleost arterial elastin is almost exclusively found in a fibrillar form, a morphology shared with the bulbus. While the fibrils of elastin superficially resemble the glycoprotein microfibrils of mammalian elastic fibres, Serafini-Fracassini et al (1978), Benjamin et al (1983) and Isokawa et al (1988) have demonstrated, using elastases, elastin stains and molecular analyses, that the fibrils are elastin.…”

Section: Discussionmentioning

confidence: 99%

“…Teleost elastin is chemically distinct from other elastin variants (Serafini-Fracassini et al, 1978;Spina et al, 1979;Sage, 1982;Chow et al, 1989), with a decreased hydrophobic index due to an increase in polar amino acids. As much of the recoil in elastin is driven by hydrophobic interactions, this may result in a lower elastic modulus.…”

Section: H Braun and Othersmentioning

confidence: 99%

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Form and function of the bulbus arteriosus in yellowfin tuna (Thunnus albacares), bigeye tuna (Thunnus obesus) and blue marlin(Makaira nigricans): static properties

Braun

Brill²,

Gosline

et al. 2003

Journal of Experimental Biology

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SUMMARY The juxtaposition of heart and gills in teleost fish means that the Windkessel function characteristic of the whole mammalian arterial tree has to be subserved by the extremely short ventral aorta and bulbus arteriosus. Over the functional pressure range, arteries from blue marlin (Makaira nigricans) and yellowfin tuna (Thunnus albacares) have J-shaped pressure-volume (P-V) loops, while bulbi from the same species have r-shaped P-V loops, with a steep initial rise followed by a compliant plateau phase. The steep initial rise in pressure is due to the geometry of the lumen. The interactions between radius, pressure and tension require a large initial pressure to open the bulbar lumen for flow. The plateau is due to the unique organization of the bulbar wall. The large elastin:collagen ratio, limited amount of collagen arranged cirumferentially, lack of elastin lamellae and low hydrophobicity of the elastin itself all combine to lower stiffness, increase extensibility and allow efficient recoil. Even though the modulus of bulbus material is much lower than that of an artery, at large volumes the overall stiffness of the bulbus increases rapidly. The morphological features that give rise to the special inflation characteristics of the bulbus help to extend flow and maintain pressure during diastole.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: H Braun and Othersmentioning

confidence: 99%

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Form and function of the bulbus arteriosus in yellowfin tuna (Thunnus albacares), bigeye tuna (Thunnus obesus) and blue marlin(Makaira nigricans): static properties

Braun

Brill²,

Gosline

et al. 2003

Journal of Experimental Biology

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“…[34] The observed tropoelastin and aggregate structures are similar to those found in natural tissues, as evidenced by electron microscopy, which supports the concept of an aggregation unit corresponding to tropoelastin assemblies. [35,36] Unlike other fibrous proteins such as collagen, there are no good X-ray images for elastin due to anisotropic protein distribution needed for multidirectional elasticity. These data and the order of molecular assembly, combined with the similarity of the physical properties of crosslinked tropoelastin with elastin, indicate other elastic tissue components are not needed for templating to a native arrangement and so allow sufficient strain within a crosslinked network.…”

Section: Tropoelastin Assemblymentioning

confidence: 99%

Perspectives on the Molecular and Biological Implications of Tropoelastin in Human Tissue Elasticity

Weiss¹

2016

Aust. J. Chem.

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The elasticity of a range of vertebrate and particularly human tissues depends on the dynamic and persistent protein elastin. This elasticity is diverse, and comprises skin, blood vessels, and lung, and is essential for tissue viability. Elastin is predominantly made by assembling tropoelastin, which is an asymmetric 20-nm-long protein molecule. This overview considers tropoelastin's molecular features and biological interactions in the context of its value in tissue repair.

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Bulbus arteriosus of the antarctic teleosts. I. The white-bloodedChionodraco hamatus

et al. 1999

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The bulbus arteriosus of teleost fish is a thick-walled chamber that extends between the single ventricle and the ventral aorta. The functional importance of the bulbus resides in the fact that it maintains a steady blood flow into the gill system through heart contraction. Despite of this, a thorough study of the structure of the bulbus in teleost fish is still lacking. We have undertaken a morphologic study of the bulbus arteriosus in the stenothermal teleosts of the Antarctic sea. The structural organization of the bulbus arteriosus of the icefish Chionodraco hamatus has been studied here by conventional light, scanning, and transmission electron microscopy.The inner surface of the bulbus shows a festooned appearance due to the presence of longitudinal, unbranched ridges that extend between the ventricle and the arterial trunk. The wall of the bulbus is divided into endocardial, subendocardial, middle, and external layers. Endocardial cells show a large number of moderately-dense bodies. The endocardium invaginates into the subendocardium forming solid epithelial cords that contain numerous secretory vacuoles. Cells in the subendocardium group into small domains, have some of the morphological characteristics of smooth muscle cells, and appear enmeshed in a three-dimensional network of matrix filaments. Cells in the middle layer are typical smooth muscle cells. They appear arranged into layers and are surrounded by a filamentous meshwork that excludes collagen fibers. Orientation of this meshwork occurs in the vicinity of the smooth muscle cells. Elastin fibers are never observed. The external layer is formed by wavy collagen bundles and fibroblast-like cells. This layer lacks blood vessels and nerve fibers.The endocardium and the endocardium-derived cords are secretory epithelia that may be involved in the formation of mucins or glycosaminoglycans. These mucins may have a protecting effect on the endocardium. The subendocardium and the middle layer appear to be formed by the same cell type, smooth muscle, with a gradient of differentiation from the secretory (subendocardium) to the contractile (middle layer) phenotype. Despite the absence of elastin fibers, the filamentous matrix could maintain the elastic properties of the bulbus wall. Smooth muscle cells appear to be actively involved in bulbus wall dynamics. The restriction of collagen to the external layer suggests that it may control wall dilatation and bulbus compliance.

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The morphological organization and ultrastructure of elastin in the arterial wall of trout (Salmo gairdneri) and salmon (Salmo salar)

Cited by 36 publications

References 18 publications

Form and function of the bulbus arteriosus in yellowfin tuna (Thunnus albacares), bigeye tuna (Thunnus obesus) and blue marlin(Makaira nigricans): static properties

Form and function of the bulbus arteriosus in yellowfin tuna (Thunnus albacares), bigeye tuna (Thunnus obesus) and blue marlin(Makaira nigricans): static properties

Perspectives on the Molecular and Biological Implications of Tropoelastin in Human Tissue Elasticity

Bulbus arteriosus of the antarctic teleosts. I. The white-bloodedChionodraco hamatus

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