The morphogenesis and fate of the nucleolar channel system in the human endometrial glandular cell

More, I. A. R.; Armstrong, E M; McSeveney, David; Chatfield, W.R.

doi:10.1016/s0022-5320(74)90027-6

Cited by 30 publications

(11 citation statements)

References 16 publications

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“…The tubules are usually delimited by the elementary membrane; very rarely, they contain pore complexes (Kessel, 1992); diameter of the tubules is larger than that of AL. These structures are present at early stages of embryogenesis (Franke, 1974;Sasaki and Kendall, 1985;Kessel, 1992), in the neoplastic cells (Bourgeois and Hubert, 1988), as well as in some special cell types, such as endometrial cells (Terzakis, 1965;More et al, 1974).…”

Section: Derivatives Of Ne At Different Stages Of the Trophoblast Celmentioning

confidence: 99%

Modifications of nuclear envelope during differentiation and depolyploidization of rat trophoblast cells

Zybina¹,

Zybina²

2008

Micron

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Section: Derivatives Of Ne At Different Stages Of the Trophoblast Celmentioning

confidence: 99%

Modifications of nuclear envelope during differentiation and depolyploidization of rat trophoblast cells

Zybina¹,

Zybina²

2008

Micron

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“…The best-documented studies of the human endometrial ultrastructure are related to special features, such as cyclic variation in endometrial ciliated cells (Masterton et al, 1975), the nucleolar channel system of human glandular cells (Terzakis, 1965;Kohorn et al, 1970Kohorn et al, ,1972More et al, 1974More et al, , 1975More and McSeveney, 19801, giant lysosomes (Cavazos and Lucas, 19701, and giant basal mitochondria (Nilsson, 1962;Armstrong et al, 1973).…”

Section: Limitations Of Ultrastructural Analyses Of Primate Endometrimentioning

confidence: 99%

Ultrastructural epithelial zonation of the primate endometrium (rhesus monkey)

Kaiserman-Abramof

Padykula

1989

Am. J. Anat.

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The uterine endometrium of menstruating primates (rhesus monkey, human) consists of a germinal basalis that regenerates a transient functionalis during each menstrual cycle. The endometrium is further subdivided into 4 zones that differ histologically and in epithelial mitotic rate along the longitudinal axes of the uterine glands and microvasculature (Bartelmez et al: Contrib. Embryol. Carnegie Inst., 34:99-146, 1951; Bartelmez: Am. J. Obstet. Gynecol., 74:931-955, 1957; Padykula et al.: Biol. Reprod., 32:1103-1118, 1118, 1984; Biol. Reprod., in press, 1988). The zones are defined as follows: functionalis I, luminal epithelium; functionalis II (upper straight gland segments); basalis III (middle gland segments), and basalis IV (bottoms of the glands). The surrounding stroma and microvasculature also differ zonally. Ultrastructural epithelial differences are evident among the 4 zones during 3 distinct functional states during natural menstrual cycles and after ovariectomy: 1) basal level after ovariectomy and 2) estrogen dominance and 3) progesterone dominance. Zonal structural differences persist at a minimal level of differentiation after ovariectomy and thus zonation is an inherent property. During estrogen dominance, distinctive ultrastructural differences are evident among the 4 zones, such as epithelial cell heterogeneity in functionalis I and homogeneity in functionalis II. Also a distinctive glandular cell type occurs in basalis III and IV that is recognized by a highly irregular cisternal rough endoplasmic reticulum that permeates the cytoplasm. During progesterone dominance, ultrastructural differences exist among the 4 zones except for similarity between the epithelial cells of functionalis II and basalis III. Postovulatory epithelial cells of functionalis I and II and basalis III become postmitotic via progesterone inhibition but intracellular differentiation continues progressively. Postovulatory epithelial mitotic activity in basalis IV escapes progesterone inhibition as the [3H]thymidine labeling index continues to increase from 1 to 12% during the menstrual cycle (Padykula et al.: Reprod., 30(Suppl.1):92 (Abstr. 123), 1984). This post-ovulatory proliferation coupled with progressive differentiation in basalis IV may represent a stem-progenitor set of cells for postmenstrual endometrial regeneration or alternatively for creation of the maternal placenta.

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“…The nucleolar channel system varies in shape -it may be that of an ellipsoid, a torus or a sphere, either solid or hollow [Terzakis, 1965], More et al [1974] have described the NCS as a helical arrangement of tubules around a hollow sphere. At times, a small amount of cytoplasm invaginates into the nucleus towards the nucleolar channel system, but the nuclear envelope is intact, and thus, there is no direct contact between the nucleoplasm and the cyto plasm.…”

Section: Secretory Phasementioning

confidence: 99%

Ultrastructural Changes in Human Endometrium at Different Phases of the Menstrual Cycle and Their Functional Significance

Verma¹

1983

Gynecol Obstet Invest

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A review of the ultrastructure of normal human endometrium at different phases of the cycle is presented. The structural changes are correlated to the functional implications in the light of the recent knowledge on the functioning of cell organelles. Relatively undifferentiated cells of the beginning of the menstrual phase become functionally matured, proliferate and later degenerate. The appearance of the nucleolar channel system during the secretory phase coincides with the rise of progesterone level and facilitates the nucleocytoplasmic exchange. The secretion of the endometrial glands consists of glycogen, glycoproteins, lipids and mucopolysaccharides. Large autophagic vacuoles (giant lysosomes) digest various cell components at the end of the cycle. All the lamina functionalis of the endometrium is not shed, a part of it is regressed by focal death (autophagic vacuoles) and by total death (apoptosis) of individual cells.

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The morphogenesis and fate of the nucleolar channel system in the human endometrial glandular cell

Cited by 30 publications

References 16 publications

Modifications of nuclear envelope during differentiation and depolyploidization of rat trophoblast cells

Modifications of nuclear envelope during differentiation and depolyploidization of rat trophoblast cells

Ultrastructural epithelial zonation of the primate endometrium (rhesus monkey)

Ultrastructural Changes in Human Endometrium at Different Phases of the Menstrual Cycle and Their Functional Significance

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