The Montreal Cognitive Assessment (MoCA) as a screening test for cognitive dysfunction in multiple sclerosis

Freitas, Sandra; Batista, Sónia; Afonso, Ana; Simões, Mário R.; Sousa, Lívia; Cunha, Luı́s; Santana, Isabel

doi:10.1080/23279095.2016.1243108

Cited by 41 publications

(35 citation statements)

References 58 publications

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“…The present study showed that MS patients have a statistically significant higher MFIS score (physical, cognitive, and psychosocial) and a statistically significant low MoCA score than the controlled group. This finding met with those of Pellicano and colleagues ( 2010 ) and Freitas and colleagues ( 2018 ) respectively.…”

Section: Discussionsupporting

confidence: 84%

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Nageeb

Hashim

Fawzy

2018

Egypt J Neurol Psychiatry Neurosurg

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BackgroundMultiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients.MethodsThis study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale.ResultsThere was no significant difference between patients and controls regarding serum IGF-1 levels (P = 0.19). However, low serum levels of IGF-1 have significantly greater odds for fatigue (P = 0.002) and cognitive impairment (P < 0.001). Also, serum IGF-1 levels have a significant negative correlation with MFIS (r = − 0.701 and P < 0.001) and a significant positive correlation with MoCA scale (r = + 0.84 and P < 0.001).ConclusionsThe results, specifically that low levels of serum IGF-1 was associated with cognitive impairment and fatigue in MS, suggest that IGF-I may be involved in the pathogenesis of cognitive deficits and fatigue in MS disease.

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Section: Discussionsupporting

confidence: 84%

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Nageeb

Hashim

Fawzy

2018

Egypt J Neurol Psychiatry Neurosurg

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“…We used the same battery as in Serino et colleagues 19 : global cognitive level was assessed with the Montreal Cognitive Assessment (MoCA) 28 – which has been shown to be sensitive in identifying MS-related cognitive impairment 29 ; executive functioning was assessed using the Trail Making Test 30 (in two specific sub-tests: TMT-A and TMT-B) as a visuo-spatial examination with an index of time; PIT 360°; and a measure of phonemic verbal fluency, the controlled oral word association test (FAS form) 23 .…”

Section: Methodsmentioning

confidence: 99%

An ecological measure to screen executive functioning in MS: the Picture Interpretation Test (PIT) 360°

Realdon

Serino

Savazzi

et al. 2019

Sci Rep

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Executive functions are crucial for performance of everyday activities. In Multiple Sclerosis (MS), executive dysfunctions can be apparent from the early onset of the disease. Technology-based time-efficient and resource-saving tools for early evaluation of executive functions using an ecological approach are needed to assess functional performance in real-life. The aim was to compare the efficiency of the Picture Interpretation Test 360° (PIT 360°) with traditional measures on executive dysfunction in Persons with Multiple Sclerosis (PwMS) and Healthy Controls (HC). Participants were 31 patients with Relapsing-Remitting MS (mean age = 44.323 ± 13.149; mean Expanded Disability Status Scale = 2) and 39 HC (mean age = 39.538 ± 15.728). All were tested with standard neuropsychological tests of executive functions, PIT 360°, and measures of user experience. While standard neuropsychological tests failed to differentiate between PwMS and HC group, the PIT 360° was successful in detecting executive dysfunction in PwMS. All participants reported the PIT 360° to be an engaging tool and endorsed positive reactions to their experience. Overall, the PIT 360° is a quick, sensitive, and ecological tool that captures real-world executive dysfunction in PwMS. This engaging measure is sensitive for the detection of executive deficits since the early phases of the disease.

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“…The Montreal Cognitive Assessment (MoCA) is a sensitive and reliable 10-minute cognitive screening test. 35, 36 It has been used successfully as a screening tool for cognitive impairment in MS. 36 Higher scores indicated better performance and a score ≥26 out of 30 is considered normal.…”

Section: Methodsmentioning

confidence: 99%

Uncovering the association between fatigue and fatigability in multiple sclerosis using cognitive control

Cehelyk

Harvey

Grubb

et al. 2019

Multiple Sclerosis and Related Disorders

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Background: Fatigue and cognitive dysfunction are two common symptoms experienced by patients with multiple sclerosis (MS). The relationship between subjective and objective fatigue (fatigability) in MS is poorly understood. Cognitive control tasks might be more conducive to fatigability and more likely to show associations between subjective and objective cognitive fatigue in MS. Objective: To study the association between objective fatigability, as induced by a cognitive control task called the Blocked Cyclic Naming Task (BCNT), subjective fatigue and baseline cognitive functioning in patients with MS. Methods: Twenty-one patients with MS completed baseline questions about their disease, the Montreal Cognitive Assessment (MoCA) battery and self-reported questionnaires on trait fatigue, sleep and depression. Disability was captured using the expanded disability status scale (EDSS). Participants then performed the BCNT and were asked about their level of state momentary fatigue before and after the BCNT. The BCNT consists of several blocks of either related or unrelated pictures that participants name as quickly as possible. The pictures cycled 4 times in each block and the difference in the response times (RTs) between related and unrelated blocks was captured. Data were analyzed using repeated measures analysis of variance and Pearson correlations. Results: MS participants’ performance declined for the related, but not unrelated blocks. The difference in RTs between related and unrelated conditions increased with repetition across cycles (p < 0.001). Participants also showed objective fatigability with less repetition priming (p = 0.02) in the 4th quarter and with greater differences between related and unrelated conditions in the later part of the task. Objective fatigability was strongly associated with participants’ assessment of their level of momentary state fatigue (r =0.612, p =0.007). Conclusion: Using the appropriate tools, this study showed an association between subjective and objective cognitive fatigue in people with MS. The BCNT and cognitive control are useful tools in assessing patients with MS and should be explored in future, larger studies in this population.

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The Montreal Cognitive Assessment (MoCA) as a screening test for cognitive dysfunction in multiple sclerosis

Abstract: Conclusions: The MoCA is a useful and sensitive instrument to identify the MS-related cognitive impairment.

Cited by 41 publications

References 58 publications

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

An ecological measure to screen executive functioning in MS: the Picture Interpretation Test (PIT) 360°

Uncovering the association between fatigue and fatigability in multiple sclerosis using cognitive control

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