The monophasic pattern in oral glucose tolerance test as a predictive risk factor of type 2 diabetes in obese paediatric patients

Herrera‐Martínez, Aura D.; Enes, Patricia; Martín-Frías, Maria; Roldán, Belén; Yelmo, Rosa; Barrio, Raquel

doi:10.1016/j.anpede.2017.08.003

“…Potential perceived limitations would be that we have no anthropometric data, such as body mass index (BMI) and waist circumference, which could have an influence on glycemic status. But previous research showed that the OGTT response curve shape remained strongly associated with insulin sensitivity and β-cell function after adjusting for BMI, blood pressure, and waist circumference [6,8]. In addition, our research follows the standard methods used in China.…”

Section: Discussionmentioning

confidence: 99%

“…Cross-sectional studies in youths [6][7][8][9][10][11][12][13] and adults [11][12][13]23] showed that the shape of the OGTT glucose response curve could indicate insulin sensitivity and b-cell function, as well as differentiate type 2 diabetes risk. Obese youths with monophasic glucose response curves were worse in both hepatic and peripheral insulin sensitivity measured by the clamp method compared with the biphasic group, as well as in b-cell function, which was indicated by impaired disposition index as a result of lacking in a compensatory increase in first and second-phase insulin secretion [6].…”

Section: Discussionmentioning

confidence: 99%

“…The OGTT glucose response curve could be a novel and intuitive biomarker to identify early metabolic risk [6]. Recent cross-sectional studies [6][7][8][9][10][11][12][13] showed that OGTT response curves, either monophasic or biphasic, can not only indicate b-cell function and insulin resistance but also differentiate diabetes risk. Those studies revealed that individuals with a monophasic curve tended to have worse insulin sensitivity and b-cell function.…”

Section: Introductionmentioning

confidence: 99%

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The shape of the glucose response curve during an OGTT heralds β−cell function in a large Chinese population

Cheng

¹

,

Yang

²

,

Li

³

et al. 2019

Preprint

0

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Background The shape of the glucose response during an oral glucose tolerance test can detect β-cell function and insulin resistance. But there were few studies in Chinese, so we aimed to verify the utility of these connections in a large Chinese population. Methods A total of 11,866 times of 3-h OGTT were categorized to either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, Matsuda index, insulinogenic index and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT. Results Individuals with a monophasic shape had significantly higher glucose, insulin, and had significantly lower insulin sensitivity and impaired β-cell function than multiphasic group. In addition, Individuals were younger with a multiphasic shape compared to those with a monophasic shape. Conclusion The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

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“…Cross-sectional studies in youth [3][4][5][6][7][8][9][10] and adults [8][9][10]18] showed that the shape of the OGTT glucose response curve could indicate insulin sensitivity and β-cell function, as well as differentiate type 2 diabetes risk. Obese youths with monophasic glucose response curves were worse in both hepatic and peripheral insulin sensitivity measured by the clamp method compared with the biphasic group, as well as β-cell function which was presented as impaired disposition index as a result of lacking in compensatory increase in first and second-phase insulin secretion [3].…”

Section: Discussionmentioning

confidence: 99%

“…The OGTT glucose response curve can be a novel and intuitive biomarker to identify early metabolic risk [3]. Recent cross-sectional studies [3][4][5][6][7][8][9][10] showed that OGTT response curves, either monophasic or biphasic, can not only detect β-cell function and insulin resistance, but also differentiate diabetes risk. Those studies revealed that individuals with a monophasic curve tended to have worse insulin sensitivity and β-cell function.…”

Section: Introductionmentioning

confidence: 99%

The shape of the glucose response curve during an OGTT heralds β−cell function in a large Chinese population

Cheng

¹

,

Yang

²

,

Li

³

et al. 2019

Preprint

0

View full text Add to dashboard Cite

Background The shape of the glucose response during an oral glucose tolerance test can detect β-cell function and insulin resistance. But there were few studies in Chinese, so we aimed to verify the utility of these connections in a large Chinese population. Methods A total of 11,866 times of 3-h OGTT were categorized to either a monophasic or a multiphasic group based on the shape of the glucose response. Homeostasis model assessments of fasting insulin resistance, Matsuda index, insulinogenic index and the disposition index were assessed by plasma glucose and serum insulin concentration obtained at fasting or during an OGTT. Results Individuals with a monophasic shape had significantly higher glucose, insulin, and had significantly lower insulin sensitivity and impaired β-cell function than multiphasic group. In addition, Individuals were younger with a multiphasic shape compared to those with a monophasic shape. Conclusion The monophasic OGTT glucose response curve could reflect impaired β-cell function in a large Chinese population.

show abstract