The Monoamine Oxidase Inhibitor, Phenelzine, in the Treatment of Depressive-Anxiety States

Robinson, Donald S.; Nies, Alexander; Ravaris, C. Lewis; Lamborn, Kathleen R.

doi:10.1001/archpsyc.1973.04200030093015

Cited by 159 publications

(32 citation statements)

References 38 publications

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“…The DSM-IV's concept of atypical depression was created by DF Klein and his group from Columbia University in the USA on the basis of response to monoamine oxidase inhibitors (Sotsky and Simmens 1999; Stewart et al 1997Stewart et al , 1993Thase et al 1991;Quitkin et al 1991Quitkin et al , 1990Quitkin et al , 1989Quitkin et al , 1988Davidson et al 1988; Liebowitz et al 1988; Mountjoy et al 1977; Ravaris et al 1976; Robinson et al 1973). The DSM-IV specifier for atypical features requires: a) the presence of mood reactivity, and b) two or more of the following four symptoms: interpersonal rejection sensitivity, leaden paralysis, significant weight gain or overeating and oversleeping.…”

Section: Introductionmentioning

confidence: 99%

Atypical depressive syndromes in varying definitions

Angst

Gamma

Benazzi

et al. 2005

Eur Arch Psychiatry Clin Neurosci

106

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■ Abstract Background Atypical depression (AD) exhibits distinct patterns of gender, bipolar-II disorder, genetic, and neuro-biological measures. Using prospective data from a community sample, this paper identifies criteria (and correlates) for an AD syndrome that maximizes the association with female sex and bipolar-II. Methods The Zurich cohort study is composed of 591 subjects selected from a population-based cohort of young adults in the canton of Zurich in Switzerland, screened in 1978 and followed with six interviews through 1999. Seven definitions of atypical depression were tested, using varying combinations of vegetative symptoms and mood reactivity. Results The atypical definitions using 2 of 3 (fatigue, overeating, oversleeping) or 2 of 2 (overeating, oversleeping) vegetative symptoms showed the strongest association with gender, bipolarity, and family history of mania. The 2/3 definition was chosen for further analysis due to its high sensitivity for identifying these characteristics. This syndrome had cumulated weighted prevalence of 16.4 % (males 9.7 %, females 23 %); when associated with major depressive episodes, 8.2 % (males 3.2 %, females 15.1 %). AD patients were characterized by high treatment rates, severity, and work impairment, early age of onset and long illness. AD was comorbid with social phobia, binge eating, neurasthenia, migraine headache, and subjective cognitive impairment.■ Key words atypical depression · bipolar-II disorder · sex · prevalence

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Section: Introductionmentioning

confidence: 99%

Atypical depressive syndromes in varying definitions

Angst

Gamma

Benazzi

et al. 2005

Eur Arch Psychiatry Clin Neurosci

106

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“…Ancak son 10 yıl içerisinde yapılmış olan çalışmalar atipik depresyon tanı ölçütlerinin geçerliliğini yeniden tartışmaya açmıştır. [41][42][43][44][45][46][47][48][49] DSM-IV sonrası yapılan çalışmalar depresyonda atipik özelliğin major depresyona ve distimiye dahil edilmesini destek-lemiştir, ancak bu çalışmalar atipik depresyonlu hastaların hastalık seyri, biyoloji, tedavi yanıt beklentisi ve ailesel yüklülük açısından farklı olduğunu dü-şündürmüştür. [44] Bugün için en tartışmalı olduğu iddia edilen tanı ölçütü duygudurumda tepkisellik olmuştur.…”

Section: Atipik Depresyonun Tanı öLçütleriunclassified

“…Yapılan çalışmalarda atipik depresyonlu hastalarda geri dönüşümsüz MAO inhibitörü ilaçlarla yapılan randomize, çift kör, plasebo kontrollü çalışmalarda etkinliği gösterilmiştir. [47][48][49] Ayrıca MAO inhibitörleri, atipik depresyonlu hastalarda trisiklik antidepresanlara (TSA) göre daha yüksek etkinlik gösterdiği bildirilmiştir. [50][51][52][53][54][55][56][57] Henkel ve arkadaşlarının metaanalizinde MAO inhibitörü ilaçlar TSA'dan daha etkili bulunmuştur.…”

Section: Tedavi Monoamin Oksidaz (Mao) Inhibitörleriunclassified

Atypical Depression

Koyuncu¹,

Binbay²,

Ertekin³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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Atypical depression is defined as a specifier of major depressive disorder. Columbia criteria for atypical depression are commonly used to make a diagnosis. Female sex, onset at early age, chronic course, and higher rate of comorbidity (especially anxiety disorder and bipolar disorder) is noteworthy in atypical depression. Although, the atypical depression seems to support the familial genetic transition, there is not any specific study supporting these data. In the treatment of atypical depression, monoamine oxidase inhibitors are reported to be more effective than tricyclic antidepressants. In recent studies, selective serotonin reuptake inhibitors have also proven to be efficient

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“…One group has published a series of studies with phenelzine (11,15,16) which address this question. Animal (6,8) and human (5) studies both reveal that brain MAO must be inhibited by at least 85% in order to effect significant biochemical or behavioral changes in mono amines.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Response to Phenelzine and MAO Inhibition in a Clinical Trial of Phenelzine, Amitriptyline and Placebo

Raft¹,

Davidson²,

Wasik³

et al. 1981

Neuropsychobiology

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This report examines the hypothesis that for phenelzine to be more effective than placebo it is necessary to achieve at least 80% inhibition of platelet MAO activity. This hypothesis was examined in the context of a double-blind comparison of phenelzine, amitriptyline and placebo in depressed patients. When phenelzine became significantly more effective than placebo at 4 weeks, the average MAO inhibition was 85%. By the 5th week, with MAO inhibition greater than 90%, phenelzine was significantly more effective than amitriptyline. A highly significant correlation was noted between improvement and MAO inhibition within the phenelzine group.

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The Monoamine Oxidase Inhibitor, Phenelzine, in the Treatment of Depressive-Anxiety States

Cited by 159 publications

References 38 publications

Atypical depressive syndromes in varying definitions

Atypical depressive syndromes in varying definitions

Atypical Depression

Relationship between Response to Phenelzine and MAO Inhibition in a Clinical Trial of Phenelzine, Amitriptyline and Placebo

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