The Molecular Structure of Phage α

Aurisicchio, S.; Frontali, C.; Graziosi, Francesca

doi:10.1007/bf02780189

Nuovo Cim

1962

DOI: 10.1007/bf02780189

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The Molecular Structure of Phage α

S. Aurisicchio

C. Frontali

Francesca Graziosi

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1967

1970

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Cited by 2 publications

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“…It contains a double-stranded deoxyribonucleic acid (DNA) molecule (2), the strands of which exhibit a density difference in CsCl gradients (3,21) and are separable on a methylated albuminkieselguhr column (4). The DNA of this virus also presents an abnormally high sensitivity to X-irradiation and 32p decay (5,13,14). The temperate nature of the phage is peculiar in that lysogenized bacteria undergo spontaneous curing at a high rate (15), the frequency of which can be increased by acridine dye treatment (1).…”

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confidence: 99%

Genetic Map of Bacteriophage α

Kejzlarovà

Donini

Eremenko-Volpe

et al. 1970

J Virol

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Temperature-sensitive mutants of phage α were obtained by means of various mutagens and assigned to 25 complementation groups. Temperature-sensitive mutants belonging to 21 complementation groups and a mutant giving turbid plaques were used to perform two- and three-factor crosses. Seventeen of the cistrons and the turbid mutant were shown to belong to the same linear linkage group, which showed no signs of circularity. The remaining four unlinked cistrons showed peculiarities in their recombination properties. Genes which are known to be expressed earlier apear to be grouped together in a terminal segment of the linkage group.

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mentioning

confidence: 99%

Genetic Map of Bacteriophage α

Kejzlarovà

Donini

Eremenko-Volpe

et al. 1970

J Virol

Self Cite

View full text Add to dashboard Cite

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Chronology of Viral Functions in Bacteriophage α

Gaeta

Donini

Veneziani-Brizi

et al. 1967

J Virol

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Temperature-sensitive mutants of phage a were subjected to short pulses of permissive temperature at various times during the lytic cycle. All the mutants showed an optimal response to the permissive pulse at a specific time after infection. The optimal responses of the mutants belonging to the same complementation group fell close together in the same time interval; the optimal responses of mutants contained in 20 different complementation groups were more or less uniformly scattered throughout the lytic cycle. Temperature sensitivity, therefore, seems to afford, at least in the case of phage a, an independent way of grouping the genes in an ordered sequence with respect to the steps they control. The successful synthesis, within the infected host cell, of each required macromolecular product at the proper time seems to be the necessary condition for the completion of the assembly process, which ultimately leads to the production of complete and active viral particles. Until now, only a gross distinction of the viral functions in two classes, early and late, has been proposed (6, 9, 10; H. Echols et al., personal

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The Molecular Structure of Phage α

Cited by 2 publications

References 7 publications

Genetic Map of Bacteriophage α

Genetic Map of Bacteriophage α

Chronology of Viral Functions in Bacteriophage α

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