The Molecular Structure of Amino Acids

Gurskaya, G. V.

doi:10.1007/978-1-4684-1566-7

Cited by 2 publications

(2 citation statements)

References 55 publications

(90 reference statements)

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“…The increased thickness of PLL-G should be due to the assembly of PLL at both sides of graphene sheets since the diameter of lysine is 0.863 nm as measured by scanning tunneling microscopy. 65 This result is in good agreement with the one obtained from X-ray diffraction characterizations (Fig. 2c).…”

Section: Characterization Of the Pll-g Hybridsupporting

confidence: 91%

Synthesis of a hydrophilic poly-l-lysine/graphene hybrid through multiple non-covalent interactions for biosensors

Wang

Zhao

et al. 2013

J. Mater. Chem. B

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Surface modification has been proved to be one of the effective strategies for enhancing the properties of graphene sheets. When a non-covalent modification method is appropriately designed, novel opportunities for better performance of graphene nanosheets can be expected since this strategy can tailor the properties of graphene while its natural structure is retained. This paper introduces a simple route to prepare a highly biocompatible, stable and conductive graphene hybrid modified by poly-L-lysine (PLL) for biosensors using the non-covalent strategy. Results show that PLL adopts a random conformation with the nonpolar parts exposed to outside since its side chains are positively charged under neutral conditions. This conformation allows the strong adhesion of PLL to graphene surface via the hydrophobic interaction between butyl chains of PLL and graphene surface, cation-p interaction of protonated amine groups on PLL with the p electrons in graphene, and electrostatic interaction between the protonated amine groups on PLL and the negatively charged carboxyl groups remaining on graphene. All these interactions make the resultant PLL-G hybrid stable and dispersible in aqueous solutions. The resultant hybrid is then used to construct high performance biosensors. As demonstration, hemoglobin (Hb) carrying negative charges can be easily immobilized on the hybrid via electrostatic interactions with the positively charged lysine side chains of PLL modified on graphene

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Section: Characterization Of the Pll-g Hybridsupporting

confidence: 91%

Synthesis of a hydrophilic poly-l-lysine/graphene hybrid through multiple non-covalent interactions for biosensors

Wang

Zhao

et al. 2013

J. Mater. Chem. B

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show abstract

“…in the presence of 1tTTP at the following concentrations: 5 pM (7). 20 ,uM (8), 50 ,uM (9) 100 ,uM (lo), 300 PM (1 l), 600 ,uM (12). Assays 2-12 were subsequently chased with an excess of four dNTPs.…”

Section: Resultsmentioning

confidence: 99%

Modified nucleoside 5'‐triphosphates containing 2',3'‐fused threemembered rings as substrates for different DNA polymerases

et al. 1993

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S-Triphosphates of 1-(2',3'-epithio-2'.3'-dideoxy-B_D-lyxofuranosyl)thymine, l-(2',3'-eptthio-~,~-dideoxy-~-D-ribofuranosyl)th~lne and 2',3'-lyxoanhydrothymidine have been shown to be termmatton substrates for human immunodeficiency virus (HIV) and avian myeloblastosis virus (AMV) reverse transcriptases as well as DNA polymerase 1 from E. co11 and DNA polymerase j3 from rat hver. At the same time they do not terminate DNA synthesis catalysed by DNA polymerase E from human placenta. Km values of ItTTP. rtTTP and laTTP incorporation mto the DNA chain during catalysts by AMV reverse transcriptase agree closely with each other being 1.5-2.5 times higher than K,,, value for dTTP Furthermore, V,,, values for modified substrates are only 2-3 times lower than b',,,',,, for dTTP. The evidence favours the hypothesis of high affinity of modified nucleotides wtth a flattened furanosyl rmg for DNA polymerase active sites.DNA polymerase: Terminatton substrate; Modified nucleoside S-trtphosphate

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The Molecular Structure of Amino Acids

Cited by 2 publications

References 55 publications

Synthesis of a hydrophilic poly-l-lysine/graphene hybrid through multiple non-covalent interactions for biosensors

Synthesis of a hydrophilic poly-l-lysine/graphene hybrid through multiple non-covalent interactions for biosensors

Modified nucleoside 5'‐triphosphates containing 2',3'‐fused threemembered rings as substrates for different DNA polymerases

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