2018
DOI: 10.1002/path.5057
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The molecular pathology of cancer: from pan‐genomics to post‐genomics

Abstract: As the cancer genomics of most major cancer types have been comprehensively catalogued over the past decade through a variety of national and international efforts, the delineation of cancer subtypes has been refined, and our understanding of critical cancer drivers and of the potentially targetable vulnerabilities that they create has grown tremendously. The 2018 Annual Review Issue of the Journal of Pathology provides in-depth assessments of how these pan-genomic approaches have enabled advances in cancer cl… Show more

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Cited by 25 publications
(19 citation statements)
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“…Despite the late transition from pan-genomics to the post-genomics era, BC still remains one of the main causes of cancer related deaths [ 30 ]. TNBC is the most aggressive subtype of BC and it presents the worse clinical outcome among BC cases [ 2 ].…”
Section: Discussionmentioning
confidence: 99%
“…Despite the late transition from pan-genomics to the post-genomics era, BC still remains one of the main causes of cancer related deaths [ 30 ]. TNBC is the most aggressive subtype of BC and it presents the worse clinical outcome among BC cases [ 2 ].…”
Section: Discussionmentioning
confidence: 99%
“…More recently, studies have shifted to better understanding the association between TIME and tumorigenesis. Genomic analysis is a standard approach for studying the structure, function, evolution, and effects of genomes on organisms (5). Several methods have been established to act as a bridge between gene expression and immune cell components.…”
Section: Introductionmentioning
confidence: 99%
“…A tumor is the final stage of a multistep genetic process that involves "cancer genes" [8] and the inhibitory and stimulatory signals that they produce [9]. In hematopoietic and lymphoid tissue, the definition of neoplasia relies on molecular tools to distinguish monoclonal from polyclonal cell proliferation.…”
Section: Impact Of Molecular-genetic Data On Tumor Classification Andmentioning
confidence: 99%