The Molecular Pathology of Burkitt Lymphoma

Mosse, Claudio A.; Weck, Karen E.

doi:10.1007/978-1-4419-5698-9_23

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2013

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“…Whereas MYC translocation is found in almost all BL, it may be seen as well in some cases of diffuse large B-cell lymphoma (DLBCL) which is much more common, and may have a different treatment approach [7]. …”

Section: Discussionmentioning

confidence: 99%

Burkitt's Lymphoma in a Pregnant Woman: Case Report and Review of the Literature

Zagalo

Pierdomenico²,

Cabeçadas³

et al. 2013

Case Reports in Oncological Medicine

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Burkitt's lymphoma (BL) is an aggressive B-cell malignancy with very high proliferation rate, more common in males than females. Here, we describe a case of Burkitt's lymphoma in a 24-week pregnant woman with cervical and abdominal involvement. The common genetic event of virtually all BL is a reciprocal chromosomal translocation involving the proto-oncogene MYC and one of the Ig gene heavy or light chain loci. Supportive treatment was administered until early delivery, after which the patient was treated according to protocol LMB96. Pregnancy and tumorogenesis share some important events such as immunologic tolerance, angiogenesis, and editing the host immune response. Little is known about the relationship between these events in pregnancy and in tumorogenesis.

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Section: Discussionmentioning

confidence: 99%