The molecular mechanisms of extracellular matrix-derived hydrogel therapy in idiopathic pulmonary fibrosis models

Evangelista-Leite, Daniele; Carreira, Ana C.O.; Nishiyama, Milton Y.; Gilpin, Sarah E.; Miglino, Maria A.

doi:10.1016/j.biomaterials.2023.122338

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…HtrA3 might be a new target for the efficiency improvement of MSC homing. Moreover, various collagen IV-containing hydrogels, such as ECM-derived hydrogel and Collagen IV-impregnated hydrogels, have been prepared to promote tissue repair [ 36 , 37 ]. Considering collagen IV degradation ability of HtrA3, it might be included in the design of bone repair materials for regenerative medicine and our study may offer new insights for the development of bioactive materials.…”

Section: Resultsmentioning

confidence: 99%

HtrA3 paves the way for MSC migration and promotes osteogenesis

Guo,

Ma,

Wang

et al. 2024

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

HtrA3 paves the way for MSC migration and promotes osteogenesis

Guo,

Ma,

Wang

et al. 2024

Bioactive Materials

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“…The possible mechanisms of pulmonary tissue damage, fibrosis and cell death is disruption of tight-junction mediated cell-to-cell contacts, changes in extracellular matrix components and their interaction with epithelial cells, and disturbances in communication between epithelial and immune cells ( Della Latta et al, 2015 ; Evangelista-Leite et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition

Abdulaal,

Asfour,

Helmi

et al. 2024

Front. Pharmacol.

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Bleomycin is an effective antibiotic with a significant anticancer properties, but its use is limited due to its potential to induce dose-dependent pulmonary fibrosis. Therefore, this study aimed to assess the therapeutic potential of Capsaicin as an additional treatment to enhance patient tolerance to Bleomycin compared to the antifibrotic drug Pirfenidone. Pulmonary fibrosis was induced in rats through by a single intratracheal Bleomycin administration in day zero, followed by either Capsaicin or Pirfenidone treatment for 7 days. After the animals were sacrificed, their lungs were dissected and examined using various stains for macroscopic and histopathological evaluation. Additionally, the study assessed various antioxidant, anti-inflammatory, and antifibrotic parameters were assessed. Rats exposed to Bleomycin exhibited visible signs of fibrosis, histopathological alterations, increased collagen deposition, and elevated mucin content. Bleomycin also led to heightened increased inflammatory cells infiltration in the bronchoalveolar lavage, elevated fibrosis biomarkers such as hydroxyproline, alpha-smooth muscle actin (α-SMA) and transforming growth factor-beta (TGF-β1), increased inflammatory markers including tumor necrosis factor-alpha (TNF-α), interlukine-6 (Il-6), interlukine-1β (Il-1β) nuclear factor-kappa B (NF-κB), and Cyclooxygenase-2 (COX-2), and transforming growth factor-beta (TGF-β1),. Furthermore, it reduced the expression of peroxisome proliferator-activated receptor-gamma (PPAR-γ), increased oxidative stress biomarkers like nitric oxide (NO), malondialdehyde (MDA), myeloperoxidase (MPO) and protein carbonyl. Bleomycin also decreased the expression of nuclear factor erythroid 2–related factor 2 (Nrf-2), reduced glutathione (GSH), total antioxidant capacity, and the activities of catalase and superoxide dismutase (SOD). Treating the animals with Capsaicin and Pirfenidone following Bleomycin exposure resulted in improved lung macroscopic and microscopic characteristics, reduced collagen deposition (collagen I and collagen III) and mucin content, decreased inflammatory cell infiltration, lowered levels of hydroxyproline, α-SMA, and TGF-β1, decreased TNF-α, Il-6, Il-1β, NF-κB, and COX-2, increased PPAR-γ and Nrf-2 expression, and improvement improved in all oxidative stress biomarkers. In summary, Capsaicin demonstrates significant antifibrotic activity against Bleomycin-induced lung injury that may be attributed, at least in part, to the antioxidant and anti-inflammatory activities of Capsaicin mediated by upregulation of PPAR-γ and Nrf-2 expression and decreasing. TGF-β1, NF-κB and COX II proteins concentrations.

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The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems

Ma,

Wu,

2024

Adv Healthcare Materials

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The challenge of the treatment of end‐stage lung disease poses an urgent clinical demand for lung tissue engineering. Over the past few years, various lung tissue‐engineered constructs are developed for lung tissue regeneration and respiratory pathology study. In this review, an overview of recent achievements in the field of lung tissue engineering is proposed. The introduction of lung structure and lung injury are stated briefly at first. After that, the lung tissue‐engineered constructs are categorized into three types: acellular, monocellular, and multicellular systems. The different bioengineered constructs included in each system that can be applied to the reconstruction of the trachea, airway epithelium, alveoli, and even whole lung are described in detail, followed by the highlight of relevant representative research. Finally, the challenges and future directions of biomaterials, manufacturing technologies, and cells involved in lung tissue engineering are discussed. Overall, this review can provide referable ideas for the realization of functional lung regeneration and permanent lung substitution.

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The molecular mechanisms of extracellular matrix-derived hydrogel therapy in idiopathic pulmonary fibrosis models

Cited by 4 publications

References 67 publications

HtrA3 paves the way for MSC migration and promotes osteogenesis

HtrA3 paves the way for MSC migration and promotes osteogenesis

Capsaicin ameliorate pulmonary fibrosis via antioxidant Nrf-2/ PPAR- γ pathway activation and inflammatory TGF-β1/ NF-κB/COX II pathway inhibition

The Development of Lung Tissue Engineering: From Biomaterials to Multicellular Systems

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