The Molecular Mechanism of PSMα3 Aggregation: A New View
Vaishnavi Tammara,
Atanu Das
Abstract:The emergence of a novel cross-α fibrillar structure,
unlike
the commonly observed sequence-independent cross-β one, of a
22-residue bacterial virulent amphipathic α-helical peptide
of the phenol soluble modulin (PSM) family, PSMα3, with many
deleterious effects on human life, has infused uncertainty to the
paradigm of the intrinsically polymorphic, multivariate, multiphasic,
and cross-sequence–cross-disease entangled protein aggregation
landscape and hence on the identity of the therapeutic target. We,
here, … Show more
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