The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial

Kawashima, Tadaomi; Ikari, Naho; Kouchi, T.; Kowatari, Yasuyuki; Kubota, Yoshiro; Shimojo, Naoki; Tsuji, Noriko M.

doi:10.1038/s41598-018-23404-4

Cited by 66 publications

(51 citation statements)

References 54 publications

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“…Probiotics promote IgA maturation in formula-fed infants by increasing the serum levels of soluble CD14 ( Rautava et al., 2006 ). P. acidilactici supplementation has been shown to promote IL-6 and IL-10 production by dendritic cells to increase mucosal IgA content in humans ( Kawashima et al., 2018 ). We observed that probiotic supplementation increased the caecal IL-10 content in this study.…”

Section: Discussionmentioning

confidence: 99%

Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models

et al. 2020

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Studies were conducted to determine the efficacy of synbiotic applications to combat the negative effects of necrotic enteritis ( NE ). An in vitro study was conducted to test the effect of probiotics species supernatants to decrease Clostridium perfringens ( CP ) proliferation. Lactobacillus reuteri , Enterococcus faecium , Bifidobacterium animalis , and Pediococcus acidilactici culture supernatants decreased the proliferation of CP at 1:1 supernatant-to-pathogen dilution in vitro. Two in vivo studies were conducted to determine the in vivo response of synbiotic supplementation containing the aforementioned probiotic strains on broiler production performance and caecal CP load in broilers induced with NE infection. In experiment 1, 75 broiler chicks were randomly allotted to 3 treatment groups, control (basal diet), ionophore (Salinomycin), and synbiotic (PoultryStar me), from day of hatch, and NE was induced in all birds. There were no significant treatment effects on BW, feed consumption, and feed gain ratio. However, at 35 D, ionophore or synbiotic supplementation increased ( P < 0.05) villi height and decreased interleukin ( IL )-1 mRNA abundance, while synbiotic supplementation increased ( P < 0.05) IL-10 mRNA abundance compared with the control group, respectively. In experiment 2, 360 broiler chicks were randomly allotted to 3 treatments, an unchallenged negative control (control; basal diet), challenged positive control (NE; basal diet), or NE + synbiotic group (synbiotic). At both 21 and 42 D of age, NE birds had decreased ( P < 0.05) BW, feed conversion, and jejunal villi height compared with control, while NE + synbiotic birds were not different from control groups. At 42 D of age, NE birds had 2.2 log/g increased CP in the ceca contents compared with control, while synbiotic birds had CP load that was not different than that of the control group. NE + synbiotic birds had significantly greater amounts of bile anti-CP IgA than the control and NE groups. It can be concluded that synbiotic supplementation decreased CP proliferation in vitro and caecal CP load in vivo while improving production parameters during an NE infection in broilers.

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Section: Discussionmentioning

confidence: 99%

Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models

et al. 2020

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“…293 Pediococcus acidilactici K15, one of the strains of lactic acid bacteria whose bacterial RNA endows DCs to secrete IL-6 and IL-10, resulting in increased B cell-derived sIgA at mucosal sites in humans. 294 Intriguingly, crosstalk between gut microbiome and IgA is not limited in the gut. For example, intestinal commensal also exerts evident effects on the serum IgA repertoire.…”

Section: Microbiota-mediated Modulation Of Th1 Cellsmentioning

confidence: 99%

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang

Tang

Chen

et al. 2019

Sig Transduct Target Ther

182

151

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The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy. Given the plasticity in microbial composition and function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, and probiotics, as well as fecal microbial transplantation, potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes. Herein, we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism, the effects of the microbiome on extraintestinal cancers and the immune response, and strategies to modulate the gut microbiome, and we discuss ongoing studies and future areas of research that deserve focused research efforts.

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“…DC-SIGN and MR are involved in IgA recognition by DCs [125]. Recognition of IgA by DCs is accompanied by inhibition of the Th1 cytokine IL-12 [126] and increased IL-10 production [127]. Increased IgA production in the intestine may have a regulatory effect on intestinal DCs.…”

Section: β-Glucansmentioning

confidence: 99%

Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics

Zmrhal

Sláma

2020

Animals

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Although the immunomodulatory properties of prebiotics were demonstrated many years ago in poultry, not all mechanisms of action are yet clear. Dendritic cells (DCs) are the main antigen-presenting cells orchestrating the immune response in the chicken gastrointestinal tract, and they are the first line of defense in the immune response. Despite the crucial role of DCs in prebiotic immunomodulatory properties, information is lacking about interaction between prebiotics and DCs in an avian model. Mannan-oligosaccharides, β-glucans, fructooligosaccharides, and chitosan-oligosaccharides are the main groups of prebiotics having immunomodulatory properties. Because pathogen-associated molecular patterns on these prebiotics are recognized by many receptors of DCs, prebiotics can mimic activation of DCs by pathogens. Short-chain fatty acids are products of prebiotic fermentation by microbiota, and their anti-inflammatory properties have also been demonstrated in DCs. This review summarizes current knowledge about avian DCs in the gastrointestinal tract, and for the first-time, their role in the immunomodulatory properties of prebiotics within an avian model.

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The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial

Cited by 66 publications

References 54 publications

Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models

Research Note: Effect of synbiotic supplementation on caecal Clostridium perfringens load in broiler chickens with different necrotic enteritis challenge models

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Immunomodulation of Avian Dendritic Cells under the Induction of Prebiotics

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