The molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology

Mohamedi, Yamina; Fontanil, Tania; Cobo, Teresa; Vega, J.A.; García‐Suárez, Olivia; Cobo, Juan; Cal, Santiago; Obaya, Álvaro J.

doi:10.20517/2394-4722.2018.81

Cited by 3 publications

(4 citation statements)

References 45 publications

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“…Additionally, in patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPNs), a significantly increased expression of fibulin-1 is observed, which in turn might enhance the capacity of TGF- β, as TGF- β anticipates various regulatory functions shown by fibulins and promotes cancer progression [ 95 ]. In contrast, the interaction of fibulin-1 with ADAMTS-1 in breast cancer cell lines induces an anticancer effect [ 96 ]. Another study on ovarian cancer reported an increased expression of the fibulin-1C splice variant, concluding that fibulin-1C promotes the progression of ovarian cancer [ 97 ].…”

Section: Role Of Fibulins During Cancer Progressionmentioning

confidence: 99%

Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases

Mahajan

Kancharla²,

Kolli

et al. 2021

Biomolecules

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The extracellular matrix (ECM) plays an important role in the evolution of early metazoans, as it provides structural and biochemical support to the surrounding cells through the cell–cell and cell–matrix interactions. In multi-cellular organisms, ECM plays a pivotal role in the differentiation of tissues and in the development of organs. Fibulins are ECM glycoproteins, found in a variety of tissues associated with basement membranes, elastic fibers, proteoglycan aggregates, and fibronectin microfibrils. The expression profile of fibulins reveals their role in various developmental processes such as elastogenesis, development of organs during the embryonic stage, tissue remodeling, maintenance of the structural integrity of basement membrane, and elastic fibers, as well as other cellular processes. Apart from this, fibulins are also involved in the progression of human diseases such as cancer, cardiac diseases, congenital disorders, and chronic fibrotic disorders. Different isoforms of fibulins show a dual role of tumor-suppressive and tumor-promoting activities, depending on the cell type and cellular microenvironment in the body. Knockout animal models have provided deep insight into their role in development and diseases. The present review covers details of the structural and expression patterns, along with the role of fibulins in embryonic development and disease progression, with more emphasis on their involvement in the modulation of cancer diseases.

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Section: Role Of Fibulins During Cancer Progressionmentioning

confidence: 99%

Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases

Mahajan

Kancharla²,

Kolli

et al. 2021

Biomolecules

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“…However, fibulin-1 expression in the stroma is associated with increased malignancy in ovarian and breast cancers (32). Thus, the ambiguous function associated with fibulin-1 in tumor-related processes has several possible explanations: posttranslational modifications, such as the proteolytic processes affecting fibulin-1 in mammary tumors; alternative splicing, which generates the different forms of fibulin-1; interaction of fibulin-1 with different components of the ECM; or even the areas where fibulin-1 is expressed [stromal vs. tumor cells; (22, 33–35)].…”

Section: Fibulin-1 and Its Associations With Adamtssmentioning

confidence: 99%

“…In a recent study, the interaction between fibulin-1 and ADAMTS-1 was associated with antitumor effects in breast cancer cell lines (35). In fact, over-expression of exogenous ADAMTS-1 and fibulin-1 resulted in a reduction in the invasive and migratory phenotypes of these cell lines.…”

Section: Fibulin-1 and Its Associations With Adamtssmentioning

confidence: 99%

Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs

et al. 2019

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The maintenance of tissue homeostasis in any organism is a very complex and delicate process in which numerous factors intervene. Cellular homeostasis not only depends on intrinsic factors but also relies on external factors that compose the microenvironment or cellular niche. Thus, extracellular matrix (ECM) components play a very important role in maintaining cell survival and behavior, and alterations in the ECM composition can lead to different pathologies. Fibulins and ADAMTS metalloproteases play crucial roles in the upkeep and function of the ECM in different tissues. In fact, members of both of these families of secreted multidomain proteins can interact with numerous other ECM components and thus shape or regulate the molecular environment. Individual members of both families have been implicated in tumor-related processes by exhibiting either pro- or antitumor properties. Recent studies have shown both an important relation among members of both families and their participation in several pathologies, including cardiogenesis or cancer. In this review, we summarize the associations among fibulins and ADAMTSs and the effects elicited by those interactions on cellular behavior.

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“…One study shows that overexpression of FBLN-1 in breast cancer cell lines promotes resistance to doxorubicin [ 36 ], whereas another study reports that inhibition of FBLN-1 in cancer cell lines increases the sensitivity to the same drug [ 37 ]. It is also reported that FBLN-1 interacts with the protumor ADAMTS-1 to block the activity of the latter in promoting the proliferation and migration of breast cancer cells [ 38 ]. Because of the scarcity of literature on the role of the ectopic FBLN-1 protein in the growth suppression of breast cancer cells, this subject matter may open up a new direction for cancer research.…”

Section: Discussionmentioning

confidence: 99%

CD36+ Fibroblasts Secrete Protein Ligands That Growth-Suppress Triple-Negative Breast Cancer Cells While Elevating Adipogenic Markers for a Model of Cancer-Associated Fibroblast

Jabbari

Cheng

Winkelmaier

et al. 2022

IJMS

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Tumor and stroma coevolve to facilitate tumor growth. Hence, effective tumor therapeutics would not only induce growth suppression of tumor cells but also revert pro-tumor stroma into anti-tumoral type. Previously, we showed that coculturing triple-negative or luminal A breast cancer cells with CD36+ fibroblasts (FBs) in a three-dimensional extracellular matrix induced their growth suppression or phenotypic reversion, respectively. Then, we identified SLIT3, FBLN-1, and PENK as active protein ligands secreted from CD36+ FBs that induced growth suppression of MDA-MB-231 breast cancer cells and determined their minimum effective concentrations. Here, we have expanded our analyses to include additional triple-negative cancer cell lines, BT549 and Hs578T, as well as HCC1937 carrying a BRCA1 mutation. We show that the ectopic addition of each of the three ligands to cancer-associated fibroblasts (CAFs) elevates the expression of CD36, as well as the adipogenic marker FABP4. Lastly, we show that an agonist antibody for one of the PENK receptors induces growth suppression of all cancer cell lines tested but not for non-transformed MCF10A cells. These results clearly suggest that proteins secreted from CD36+ FBs induce not only growth suppression of tumor cells through binding the cognate receptors but also increasing adipogenic markers of CAFs to reprogram tumor stroma.

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The molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology

Cited by 3 publications

References 45 publications

Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases

Role of Fibulins in Embryonic Stage Development and Their Involvement in Various Diseases

Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs

CD36+ Fibroblasts Secrete Protein Ligands That Growth-Suppress Triple-Negative Breast Cancer Cells While Elevating Adipogenic Markers for a Model of Cancer-Associated Fibroblast

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