The molecular evaluation of thioredoxin (TXN1 &amp; TXN2), thioredoxin reductase 1 (TXNRd1), and oxidative stress markers in a binary rat model of hypo- and hyperthyroidism after treatment with gallic acid

Najafi, Zohreh; Chamani, Elham; Zarban, Asghar; Rezaei, Zohreh; Sharifzadeh, Gholamreza

doi:10.1080/01480545.2022.2131812

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Oxidative stress was reported to exert an essential role in the development and pathology of thyroid diseases [52]. Compared with healthy controls, higher oxidative stress was observed in hypothyroid patients [53].Previous study has reported that thymoquinone can protect against the testes of hypothyroid rats by suppressing oxidative stress [54].In the current study, we revealed that ART can inhibit the oxidative stress via upregulating L1.…”

Section: Discussionsupporting

confidence: 48%

Artemisinin ameliorates the thyroid function and the complications in adult male hypothyroid rats via upregulating L1 cell adhesion molecule

Li,

Xu,

et al. 2024

Preprint

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Hypothyroidism, a common worldwide syndrome caused by in sufficient thyroid hormone secretion, affects a good deal of people at different ages. Artemisinin (ART), a well-known effective agent in the treatment of malaria, also owns anti-oxidative stress functions in various diseases. L1 cell adhesion molecule also exerts multiple protective roles in diseased systems. Hence, the aim of this study is to evaluate the role of ART in the in adult male hypothyroid rats and the underlying mechanisms. In the current study, we revealed that, ART can amelioratethe thyroid function, mitigate the depression and anxiety symptoms, attenuate the cognition impairments, improve the liver, kidney and heart functions, and inhibit the oxidative stress, whereas, theses conducive effects exerted by ART cannot be observed when L1 was silenced by L1 siRNA.These combined results indicated that ART can upregulate L1 cell adhesion molecule to ameliorate the thyroid function and the complications in adult male hypothyroid rats, laying the foundation for ART to be a novel strategy for the treatment of hypothyroidism.

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Section: Discussionsupporting

confidence: 48%

Artemisinin ameliorates the thyroid function and the complications in adult male hypothyroid rats via upregulating L1 cell adhesion molecule

Li,

Xu,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule

Li,

Xu,

et al. 2024

Thyroid Res

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Background Hypothyroidism, a common worldwide syndrome caused by insufficient thyroid hormone secretion, affects number of people at different ages. Artemisinin (ART), a well-known effective agent in the treatment of malaria, also has anti-oxidative stress functions in various diseases. The L1 cell adhesion molecule exerts multiple protective roles in diseased systems. The aim of the present study was to evaluate the role of ART in adult male hypothyroid rats and the underlying mechanisms. Methods The propylthiouracil (PTU) rat model was treated with or without 5 mg/kg ART and with or without L1 short-interfering RNA (siRNA), followed by the experiments to determine the effect of ART on thyroid function, depression and anxiety, cognition impairments, liver, kidney and heart functions, and oxidative stress. Results In the current study, it was shown that ART can ameliorate thyroid function, mitigate depression and anxiety symptoms, attenuate cognition impairments, improve liver, kidney and heart functions, and inhibit oxidative stress; however, the effects exerted by ART could not be observed when L1 was silenced by L1 siRNA. Conclusion These results indicated that ART can upregulate the L1 cell adhesion molecule to ameliorate thyroid function and the complications in adult male hypothyroid rats, laying the foundation for ART to be a novel strategy for the treatment of hypothyroidism.

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The molecular evaluation of thioredoxin (TXN1 & TXN2), thioredoxin reductase 1 (TXNRd1), and oxidative stress markers in a binary rat model of hypo- and hyperthyroidism after treatment with gallic acid

Cited by 2 publications

References 28 publications

Artemisinin ameliorates the thyroid function and the complications in adult male hypothyroid rats via upregulating L1 cell adhesion molecule

Artemisinin ameliorates the thyroid function and the complications in adult male hypothyroid rats via upregulating L1 cell adhesion molecule

Artemisinin ameliorates thyroid function and complications in adult male hypothyroid rats via upregulation of the L1 cell adhesion molecule

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