The molecular characteristics of the blood testosterone binding globulin and their regulation

The effect of ionising radiation on testosterone binding globulin characteristics: Correction of the protein' parameters by lipid polyene complexes of fungusLaetiporus sulfureus

“…Probably as part of the hypothalamic-pituitary effects of exposure to radiation accounts for the 'switching off' of the production of needed factors that provide normal TeBG and androgen receptor functions (Popoff et al 2002, Popoff 2004, Popoff and Kapich 2008. Therefore we supposed that it would be reasonable to search for a temporal replacement of the missing regulatory factors.…”

“…As for characteristics of TeBG (K a and Z Hill values) they turn out to be regulated by some tentative factors (Popoff and Kapich 2008) that detach during serum dilution (Table VI) supposedly causing 'contortion' and/or 'impairment' of the protein's tertiary structure. The inhibitors of TeBG may also be (see Figure 3) 'dissociating regulatory factor(s)'.…”

“…The functions of TeBG include transport of androgens (A), control of the exchange of these steroids in central tissues, and their clearance; also the 'active conformation' of TeBG acts as adenylate-cyclase activator and transmitter of T to plasma membrane A-receptors (Larriva-Sahd et al 1991, Porto et al 1995. The observation of mild hydroperoxide effects on TeBG parameters (Popoff and Kapich 2008) suggested a 'reserved functional role' of TeBG as an alkaline tyrosine phosphatase (ALP) since ALP activated by m 2 n 2 (10 78 -10 74 M) acted as a 'secondary' messenger (Martinovich and Cherenkevich 2006). It is noteworthy that the characteristics of TeBG are valuable markers in exploration of sex-and age-related biological changes or in clinical diagnosis of some diseases (Kato et al 1992, Hogeveen et al 2002, Munell et al 2002.…”