The molecular basis of the anti-diabetic properties of camel milk

Ayoub, Mohammed Akli; Palakkott, Abdul Rasheed; Ashraf, Arshida; Iratni, Rabah

doi:10.1016/j.diabres.2018.11.006

Cited by 73 publications

(98 citation statements)

References 50 publications

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“…On the other hand, milk has been described to suppress appetite due to its content in satiating peptides, preventing weight gain and obesity. In this sense, camel milk peptides displayed novel antidiabetic and anti-obesity activity 125,126 . Also peptides derived from the controlled digestion of algae have been described as antidiabetic (α-amylase inhibitory) and anti-obesity 91,92,127 .…”

Section: Anti-obesity and Antidiabetic Peptidesmentioning

confidence: 99%

Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity

Toldrá

Gallego

Reig

et al. 2020

J. Agric. Food Chem.

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There is a wide variety of peptides released from food proteins which are able to exert a relevant benefit for human health like angiotensin-converting enzyme (ACE) inhibition, antioxidant, anti-inflammatory, hypoglucemic or antithrombotic activity, among others. This manuscript is reviewing the recent advances on enzymatic mechanisms for the hydrolysis of food proteins, including the types of enzymes and mechanisms of action involved, the strategies followed for the isolation and identification of bioactive peptides through advanced proteomic tools, the assessment of bioactivity and its beneficial effects. Specific applications in fermented and/or ripened foods where a significant number of bioactive peptides have been reported with relevant in vivo physiological effects on laboratory rats and humans, as well as the hydrolysis of food proteins for the production of bioactive peptides are also reviewed.

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Section: Anti-obesity and Antidiabetic Peptidesmentioning

confidence: 99%

Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity

Toldrá

Gallego

Reig

et al. 2020

J. Agric. Food Chem.

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“…Camel milk is a popular commodity used in many parts of the world, particularly in arid and semi-arid zones. Camel milk's therapeutic properties against diseases such as diabetes and cancer have been widely studied and reviewed in the past decade (Alavi et al, 2017;Ayoub et al, 2018). It is also widely noted that camel milk consumption is beneficial in reducing the dose of insulin needed to induce glycemic control and improves fasting blood glucose (Agrawal et al, 2005(Agrawal et al, , 2011Mohamad et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Molecular basis of the anti-diabetic properties of camel milk through profiling of its bioactive peptides on dipeptidyl peptidase IV (DPP-IV) and insulin receptor activity

Ashraf

Mudgil

Palakkott

et al. 2021

Journal of Dairy Science

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The molecular basis of the anti-diabetic properties of camel milk reported in many studies and the exact active agent are still elusive. Recent studies have reported effects of camel whey proteins (CWP) and their hydrolysates (CWPH) on the activities of dipeptidyl peptidase IV (DPP-IV) and the human insulin receptor (hIR). In this study, CWPH were generated, screened for DPP-IV binding in silico and inhibitory activity in vitro, and processed for peptide identification. Furthermore, pharmacological action of intact CWP and their selected hydrolysates on hIR activity and signaling and on glucose uptake were investigated in cell lines. Results showed inhibition of DPP-IV by CWP and CWPH and their positive action on hIR activation and glucose uptake. Interestingly, the combination of CWP or CWPH with insulin revealed a positive allosteric modulation of hIR that was drastically reduced by the competitive hIR antagonist. Our data reveal for the first time the profiling and pharmacological actions of CWP and their derived peptides fractions on hIR and their pathways involved in glucose homeostasis. This sheds more light on the anti-diabetic properties of camel milk by providing the molecular basis for the potential use of camel milk in the management of diabetes.

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“…It was reported that there was a chronic in ammation in diabetes (37), and a greater antioxidant and immunomodulatory activity of camel milk protein than bovine and other whey proteins (8,38). Previous studies found that camel milk or camel milk whey proteins was shown to reduce the proin ammatory IL-1β, IL-6, and TNFα in diabetic rats (28,39,40).…”

Section: Changes In In Ammatory Cytokinesmentioning

confidence: 99%

“…Type 2 diabetes accounts for around 90% of diabetes worldwide, which can be effectively prevented and managed through adoption of healthy lifestyles, especially a healthy diet (1). As a result, there were many studies focused on the evaluation of the hypoglycemic activity of functional foods or ingredients, which can be mainly divided into polyphenol-enriched plant-based foods (2)(3)(4)(5) and proteins or peptides (6)(7)(8)(9). Meanwhile, since emerging evidence about the close relationship between gut microbiota with diabetes (10,11), probiotics is used as a new effective therapeutic strategy in preventing and management of diabetes (12,13).…”

Section: Introductionmentioning

confidence: 99%

Probiotic camel milk powder improves glycemic control, dyslipidemia, adipose tissue and skeletal muscle function in T2DM patients: a randomized trial

Fang

Zhang

Dong

et al. 2020

Preprint

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Background: Due to the close association between gut microbiota and diabetes, probiotic dairy products draw a lot of attention in the development of functional foods with anti-diabetic activity. Methods: 28 type II diabetic patients twice a day received 10 grams of camel milk powder supplemented with BBA6 and camel milk powder (control) over a total of 4 weeks. Results: After the intervention, there was a significant decrease in fasting blood glucose, serum content of total cholesterol, the cardiovascular risk index (TC/HDL-C), the pro-inflammatory cytokines (IL-6, MCP-1) and adipokines (adiponectin, resistin, lipocalin-2, adipsin). Myokines (irisin, osteocrin) increased significantly, indicating possible improvement in skeletal muscle function. Gut microbiota analysis suggested a significant enrichment in unclassified_f__Sphingomonadaceae and depletion in Eggerthella after the 4-week intervention with the probiotic camel milk powder, there were also elevated fecal concentrations of elevated fecal concentrations of proline, uracil and galactinol accompanied with a decreased norleucine, glycerol, sedoheptulose, palmitic acid, 5-aminovaleric acid, inositol and γ-aminobutyric acid. Conclusion: Dietary supplement with 10 grams of probiotic camel milk powder twice a day for a consecutive 4 weeks can significantly decrease fasting blood glucose of type 2 diabetic patients. This functional food also improves dyslipidemia, inflammation and functions of adipocytes and skeletal muscle, indicating the possibility of probiotic camel milk powder as a dietary treatment that target metabolic syndrome such as diabetes. Trial registration: ClinicalTrials, NCT04296825, Registered 5th March 20206 - Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT04296825.

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The molecular basis of the anti-diabetic properties of camel milk

Cited by 73 publications

References 50 publications

Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity

Recent Progress in Enzymatic Release of Peptides in Foods of Animal Origin and Assessment of Bioactivity

Molecular basis of the anti-diabetic properties of camel milk through profiling of its bioactive peptides on dipeptidyl peptidase IV (DPP-IV) and insulin receptor activity

Probiotic camel milk powder improves glycemic control, dyslipidemia, adipose tissue and skeletal muscle function in T2DM patients: a randomized trial

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