The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders

Papadopoulou, Anna; Bountouvi, Evangelia; Karachaliou, Feneli

doi:10.3390/genes12050734

Cited by 14 publications

(12 citation statements)

References 163 publications

(209 reference statements)

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“…As a ubiquitous divalent cation in the body, calcium plays a role in blood coagulation, muscle contraction, and bone mineralization [ 1 ]. Serum calcium levels are mainly controlled by the balance of calcitonin and parathyroid hormone (PTH), which may be influenced by lifestyle factors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Effects of Serum Calcium and Phosphate Levels and Their Ratio on Incident Ischemic Heart Disease among Korean Adults

2022

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Serum calcium and phosphate levels are controlled by a regulatory system, but their individual concentration tendencies and interactions may affect long-term vascular health. This study aimed to assess the effects of serum calcium and phosphate levels on incident ischemic heart disease (IHD) in a large-scale community-dwelling Korean cohort. We evaluated 15,259 non-diabetic individuals (median age, 45 years; range, 30–85) without previous IHD or ischemic stroke using the Korean National Health Insurance data. The study population was classified based on the calcium, phosphate, and calcium/phosphate ratios. Using Cox proportional hazards regression models, we estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment. The age- and sex-adjusted incidence of IHD gradually increased with serum calcium and phosphate quartiles and decreased with calcium/phosphate ratio quartiles, with an overall crude rate of 2.1% (315/15,259). After setting the lowest calcium, phosphate, and calcium/phosphate ratio quartiles as a reference group, the HRs (95% CIs) of the highest calcium, phosphate, and calcium/phosphate ratio quartiles for IHD were 1.77 (1.15–2.72), 1.73 (1.18–2.55), and 0.58 (0.39–0.87), respectively, after adjusting for potential confounding variables. Serum calcium and phosphate levels were positively associated with IHD incidence, while the serum calcium/phosphate ratio exhibited an inverse relationship. Serum calcium and phosphate homeostasis may merit serious consideration to understand the pathogenesis of coronary atherosclerosis as a risk modifier for IHD.

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Section: Introductionmentioning

confidence: 99%

Longitudinal Effects of Serum Calcium and Phosphate Levels and Their Ratio on Incident Ischemic Heart Disease among Korean Adults

2022

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“…The concentrations of calcium and phosphorus in human blood are closely related. Low calcium levels may lead to an increase in parathyroid hormone (PTH) and then promote bone to release calcium ions into the blood, increase renal phosphorus excretion, and maintain serum calcium and phosphorus homeostasis [ 18 , 19 ]. The product of blood calcium and phosphorus is closely related to osteogenesis and osteolysis.…”

Section: Discussionmentioning

confidence: 99%

Serum calcium–phosphorus product for predicting the risk of osteoporotic vertebral compression fractures in elderly patients: a retrospective observational study

Ying

Jiang

et al. 2022

J Orthop Surg Res

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Background This study retrospectively analyzed and evaluated the potential correlations of serum calcium, serum phosphorus, and calcium-phosphorus product (Ca–P product) with the incidence of osteoporotic vertebral compression fractures (OVCFs), with the aim of exploring whether the Ca–P product can be used as a serological indicator to predict the risk of OVCFs. Methods This study randomly enrolled 400 elderly patients in our hospital with OVCFs and 400 patients with hip and knee arthroplasty due to femoral head necrosis or osteoarthritis from August 2013 to April 2021. Age, sex, past medical history, and admission biochemical indicators, including albumin, blood urea nitrogen, serum creatinine, serum calcium and serum phosphorus, were collected for statistical analysis. Results Albumin, serum calcium, serum phosphorus, Ca–P product, corrected serum calcium and corrected Ca–P product were lower in the OVCF group than in the non-OVCF group (P < 0.05). Multivariate logistic regression analysis showed that low values of serum calcium, serum phosphorus, Ca–P product, corrected blood calcium, and corrected Ca–P product can all be risk factors for OVCF. The ROC curve showed that the Ca–P product and corrected Ca–P product were effective in predicting the risk of OVCFs. The predictive value of the Ca–P product was the best; the cutoff point was 29.88, the sensitivity was 0.72 and the specificity was 0.62. The cutoff point of the corrected Ca–P product was 30.50, the sensitivity was 0.74, and the specificity was 0.62. Conclusion The Ca–P product and corrected Ca–P product can be used as serological indicators to predict the risk of OVCFs in elderly individuals. Early clinical interventions targeting this risk factor can further reduce the risk of OVCFs. Also, timely and regular testing of the serum calcium and phosphorus level is recommended and encouraged for this group of people.

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“…The concentration of calcium and phosphorus in human blood are closely related. Low calcium level may lead to the increase of parathyroid hormone (PTH), and then promote bone to release calcium ions into the blood, increase renal phosphorus excretion, and maintain serum calcium and phosphorus homeostasis [19][20]. The product of blood calcium and phosphorus is closely related to osteogenesis and osteolysis.…”

Section: Discussionmentioning

confidence: 99%

Serum Calcium-Phosphorus Product for Prediction The Risk of Osteoporotic Vertebral Compression Fractures in The Elderly Patients: A Retrospective Observational Study

Ying

Jiang

et al. 2021

Preprint

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Background This study retrospectively analyzed and evaluated the potential correlation between serum calcium, serum phosphorus, calcium-phosphorus product (Ca-P product) and the incidence of osteoporotic vertebral compression fractures (OVCF), aiming to explore whether Ca-P product can be used as a serological indicator to predict the risk of OVCF. Methods This study randomly enrolled 400 elderly patients with OVCF and 400 patients with hip and knee arthroplasty due to femoral head necrosis or osteoarthritis from August 2013 to April 2021 in our hospital. The age, gender, past medical history, and the first-time biochemical indicators at admission including albumin, blood urea nitrogen, serum creatinine, serum calcium and serum phosphorus were collected for statistical analysis. Results The albumin, serum calcium, serum phosphorus, Ca-P product, corrected serum calcium and corrected Ca-P product in the OVCF group were lower than those in the Non-OVCF group (P < 0.05). Multivariate logistic regression analysis showed that low values of serum calcium, serum phosphorus, Ca-P product, corrected blood calcium, and corrected Ca-P product all can be risk factors for OVCF patients. ROC curve showed that Ca-P product and corrected Ca-P product were effective in predicting the risk of OVCF. Among them, the predictive value of Ca-P product was the best, the cut-off point was 29.88, the sensitivity was 0.72 and the specificity was 0.62. The cut-off point of corrected Ca-P product was 30.50, the sensitivity was 0.74, and the specificity was 0.62. Conclusion Ca-P product and corrected Ca-P product can be used as serological indicators to predict the risk of OVCF in the elderly. Early clinical interventions targeting this risk factor can further reduce the risk of OVCF.

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The Molecular Basis of Calcium and Phosphorus Inherited Metabolic Disorders

Cited by 14 publications

References 163 publications

Longitudinal Effects of Serum Calcium and Phosphate Levels and Their Ratio on Incident Ischemic Heart Disease among Korean Adults

Longitudinal Effects of Serum Calcium and Phosphate Levels and Their Ratio on Incident Ischemic Heart Disease among Korean Adults

Serum calcium–phosphorus product for predicting the risk of osteoporotic vertebral compression fractures in elderly patients: a retrospective observational study

Serum Calcium-Phosphorus Product for Prediction The Risk of Osteoporotic Vertebral Compression Fractures in The Elderly Patients: A Retrospective Observational Study

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