The molecular basis of brain injury in preterm infants with sepsis - associated encephalopathy

Gong, Xiaohui; Weng, Bowen; Zhang, Xiaoyue; Yan, Chongbing; Cai, Cheng

doi:10.1186/s12887-022-03372-5

Cited by 5 publications

(5 citation statements)

References 26 publications

(20 reference statements)

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“…A clinical study conducted on peripheral blood samples collected from 20 premature infants revealed a potential correlation between high expression of miRNA-1197 and low expression of miRNA-485-5p with the pathogenesis of oxidative respiratory chain and energy metabolism in premature infants with SAE. These findings suggest a possible association with mitochondrial dysfunction during SAE (Gong et al, 2022). Common neuroinflammation often affects mitochondrial health in SAE.…”

Section: Organelle Dysfunctionmentioning

confidence: 69%

The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy

Zhang,

Chen,

et al. 2024

Front. Microbiol.

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Sepsis is a condition that greatly impacts the brain, leading to neurological dysfunction and heightened mortality rates, making it one of the primary organs affected. Injury to the central nervous system can be attributed to dysfunction of various organs throughout the entire body and imbalances within the peripheral immune system. Furthermore, central nervous system injury can create a vicious circle with infection-induced peripheral immune disorders. We collate the pathogenesis of septic encephalopathy, which involves microglial activation, programmed cell death, mitochondrial dysfunction, endoplasmic reticulum stress, neurotransmitter imbalance, and blood–brain barrier disruption. We also spotlight the effects of intestinal flora and its metabolites, enterocyte-derived exosomes, cholinergic anti-inflammatory pathway, peripheral T cells and their cytokines on septic encephalopathy.

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Section: Organelle Dysfunctionmentioning

confidence: 69%

The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy

Zhang,

Chen,

et al. 2024

Front. Microbiol.

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“…Критерії діагнозу сепсису: клінічні прояви; виявлення патогенних бактерій та/або умовно-патогенної флори, культивованих із крові та асептичних зразків тіла, катетера; два або більше позитивних результатів неспецифічних тестів на маркери запалення, наприклад, вміст лейкоцитів у периферичній крові >11,0 Г/л, лейкоцитарний індекс >0,2, підвищений вміст гострого С-реактивного білка (+ якісно, або >5 ммоль/л кількісно) [6].…”

Section: матеріали та методи дослідженняunclassified

Sepsis-associated injury of the nervous system in premature infants with very low body weight

Yablon,

Vlasenko

2023

UJPP

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The immaturity of the organs and systems of preterm born children significantly complicates the differentiation between physiological and pathological changes in the brain. The etiology of brain damage in premature babies is complex and multifactorial, and even with the most favorable course of the neonatal period, they require additional respiratory support, a large number of invasive medical interventions and have a high risk of infectious complications. Sepsis-associated encephalopathy (SAE) is defined as diffuse or multifocal cerebral damage that is caused by a systemic response to infection even without clinical or laboratory evidence of direct brain infection. Purpose - to determine the clinical features of sepsis-associated brain damage in prematurely born children <32 weeks gestation with a birth weight <1500 g. Materials and methods. 38 prematurely born children, who were divided into two groups, were examined. The Group I (n=14) included children who were diagnosed with sepsis in the early neonatal period. The Group II (n=24) included prematurely born, in which no septic lesions were observed. Results. Children of both groups were born in a state of severe and moderate asphyxia. Analysis of associations between maternal, obstetric, and antenatal factors showed a significant prevalence of such factors as prelabor rupture of membranes, сervical weakness, rupture of the fetal bladder, and placement of an obstetric pessary in children with sepsis. All children with sepsis had pneumonia, acute kidney injury, and brain injury in the neonatal period. In the neurological status of children with very low birth weight who underwent SAE, the seizure syndrome, 3-4 grade intraventricular hemorrhages, periventricular leukomalacia, complications in the form of post-hemorrhagic ventriculomegaly were significantly more common. Conclusions. In children with very low birth weight who underwent SAE, convulsive syndrome, 3-4 grade intraventricular hemorrhages, and periventricular leukomalacia were significantly more common. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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“…Preliminary evidence has indicated that urine extra cellular vesicles derived miRNAs can be used as biomarkers for necrotizing enterocolitis in premature infants (36). Moreover, many studies have investigated the application of exosomal miRNAs as biomarkers or therapies in the treatment of preterm infants (37)(38)(39)(40). Multiple studies have reported changes in compositions and miRNAs within the body through diet or dietary regulation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of exosomal microRNAs in preterm infants fed with breast milk and infant formula

Kim,

Song,

et al. 2024

Front. Nutr.

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Breastfeeding not only reduces infection-related morbidity, but also increases growth of preterm infants. Advantages of breast milk (BM) for preterm infants are significant. They continue to be studied. However, because not all preterm infants can receive breastfeeding, bovine-based infant formula (IF) is used as an alternative, which may increase the risk of several preterm complications. Exosomes isolated from biofluids are emerging as biomarkers in research of various diseases. Here, we characterized miRNA contents of exosomes in urine and serum samples of preterm infants who were BM and IF fed and performed transcriptomic analysis of small RNA libraries. We identified significantly up-regulated 6 miRNAs and 10 miRNAs, respectively. Gene Ontology (GO) analysis revealed that target genes of these miRNAs might participate in neuronal development, immunity modulation, detoxification of reactive oxygen species, and transmembrane exchange. Our data suggest that exosome-based systemic screening for preterm infants with breastfeeding might be a screening tool for identifying target molecules involved in therapy for preterm infants in neonatal intensive care unit (NICU) and for future application as nutraceutical formulations or pharmaceuticals.

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The molecular basis of brain injury in preterm infants with sepsis - associated encephalopathy

Cited by 5 publications

References 26 publications

The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy

The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy

Sepsis-associated injury of the nervous system in premature infants with very low body weight

Characterization of exosomal microRNAs in preterm infants fed with breast milk and infant formula

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