The Molecular and Endocrine Basis of Flatfish Metamorphosis

Power, Deborah M.; Einarsdóttir, Ingibjörg Eir; Pittman, Karin; Sweeney, Glen E.; Hildahl, Jon; Campinho, Marco A.; Silva, Nádia; Sæle, Øystein; Galay-Burgos, Malyka; Smáradóttir, Heiðdís; Björnsson, Björn Thrándur

doi:10.1080/10641260802325377

Cited by 68 publications

(56 citation statements)

References 134 publications

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“…Therefore, it is highly probable that research will focus on detecting genes that are involved in fitness-relevant traits to develop marker-assisted selection procedures. Research on the underlying molecular mechanisms of flatfish metamorphosis (Power et al 2008) may help to identify factors contributing to abnormal metamorphosis in aquaculture. Research on QTL (Quantitative Trait Loci) associated with growth patterns and optimal temperature in turbot is in progress and genetic mapping has already started (Bouza et al 2007b).…”

Section: Selection Programs In Flatfish Farmingmentioning

confidence: 99%

Genetic population structure in flatfishes and potential impact of aquaculture and stock enhancement on wild populations in Europe

Danancher

García‐Vázquez

2011

Rev Fish Biol Fisheries

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Marine fish wild stocks are known to be heavily depleted by overfishing and flatfish species are no exception. Wild catches being soon insufficient for responding to consumer demand, the cultivation of marine species appeared as a logical response to the need of seafood. Nevertheless, fish aquaculture also entails major impacts on wild populations from which genetic ones are now better known. The hybridization between domestic and native strains potentially have a genetic impact on recipient populations as long as 1) domestic populations are distinct from native wild ones (through domestication process, genetic improvement of captive stocks) and/or 2) the native wild populations are structured (metapopulation structure, local adaptation). Some of the flatfish species exhibit population differentiation and even local adaptation and the release of domestic genetically modified fishes (selected, transgenic) could threaten their survival in case of introgression. The impact of aquaculture on flatfishes is probably still low as land-based farms and low production levels guaranty low rates of escapes and therefore limited contacts between wild and farmed strains. However, flatfish aquaculture is regarded by experts as a rapidly growing domain that will greatly develop soon. In our opinion, this perspective, added to the quite good performances of farmed flatfishes when released into the wild, fully justifies a stronger interest from the scientific community to the conservation of their wild stocks.

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Section: Selection Programs In Flatfish Farmingmentioning

confidence: 99%

Genetic population structure in flatfishes and potential impact of aquaculture and stock enhancement on wild populations in Europe

Danancher

García‐Vázquez

2011

Rev Fish Biol Fisheries

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“…Many key developmental events occur during the onset of feeding and the subsequent growing phase of actively eating larvae, making this period the most sensitive to rearing procedures. Morphological and physiological processes such as skeletal development and calcification, the differentiation and proliferation of new fibres in the myotomal musculature, achievement of complete structures in gut and gills, the progressive activation of pancreatic and intestinal digestive enzymes, swimming bladder inflation, completion of eye retina layers, development of lymphoid organs and acquisition of full immunological capacities, are dependent on complex mechanisms that regulate cell differentiation, organogenesis and the adequate functionality of organs and tissues (Alami-Durante et al 2007;Campinho et al 2010;Johnston 2006;Power et al 2008;Yúfera and Darias 2007;Zapata et al 2006). Any failure in these processes, highly dependent on the nutritional and environmental conditions as well as on the response capacity of the developing larvae to external stimuli, causes malformations, developmental delays, poor growth and massive mortalities (Barahona-Fernandez 1982;Johnston et al 1998;Koumoundouros et al 2009;Polo et al 1991;Villeneuve et al 2005;Yúfera et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Characterization of the Larval Stage in Gilthead Seabream (Sparus aurata) by 454 Pyrosequencing

et al. 2011

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Gilthead seabream (Sparus aurata) is a teleost belonging to the family Sparidae with a high economical relevance in the Mediterranean countries. Although genomic tools have been developed in this species in order to investigate its physiology at the molecular level and consequently its culture, genomic information on post-embryonic development is still scarce. In this study we have investigated the transcriptome of a marine teleost during the larval stage (from hatching to 60 days after hatching) by the use of 454-pyrosequencing technology. We obtained a total of 68,289 assembled contigs, representing putative transcripts, belonging to 54,606 different clusters.Comparison against all S. aurata expressed sequence tags (ESTs) from the NCBI database revealed that up to 34,722 contigs, belonging to about 61 % of gene clusters, are sequences previously not described. Contigs were annotated through an iterative Blast pipeline by comparison against databases such as NCBI RefSeq from Danio rerio, Swissprot or NCBI teleost ESTs. Our results indicate that we have enriched the number of annotated sequences for this species by more than 50 % compared with previously existing databases for the gilthead seabream. Gene Ontology analysis of these novel sequences revealed that there is a statistically significant number of transcripts with key roles in larval development, differentiation, morphology and growth. Finally, all information has been made available online through user-friendly interfaces such as GBrowse and a Blast server with a graphical frontend.

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“…Currently, high mortality of larvae on start-feeding diets or elevated incidences of skeletal malformations and pigment abnormalities remain bottlenecks for the development of the industry. This is in part due to the unique and critical process of metamorphosis that flatfishes experience during development when larvae shift from a planktonic to a benthic mode of life (Power et al 2008). This process not only involves morphological changes in eye migration and skin pigmentation but also important modifications of physiology and behaviour.…”

Section: Changes In Transcriptome During Larval Development and Nutrimentioning

confidence: 99%

“…This process not only involves morphological changes in eye migration and skin pigmentation but also important modifications of physiology and behaviour. However, the basic biological mechanisms involved, as well as the nutritional requirements that flatfishes demand during metamorphosis, are largely unknown, although it is recognized that this process is controlled by thyroid hormones (Miwa et al 1988;Solbakken et al 1999;Power et al 2008;. In support of this is the observation that goitrogens, substances that suppress the function of the thyroid gland, can block metamorphosis and even provoke some malformations and malpigmentations ; Fig.…”

Section: Changes In Transcriptome During Larval Development and Nutrimentioning

confidence: 99%

Advances in genomics for flatfish aquaculture

Cerdà

Manchado

2012

Genes Nutr

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Fish aquaculture is considered to be one of the most sustainable sources of protein for humans. Many different species are cultured worldwide, but among them, marine flatfishes comprise a group of teleosts of high commercial interest because of their highly prized white flesh. However, the aquaculture of these fishes is seriously hampered by the scarce knowledge on their biology. In recent years, various experimental 'omics' approaches have been applied to farmed flatfishes to increment the genomic resources available. These tools are beginning to identify genetic markers associated with traits of commercial interest, and to unravel the molecular basis of different physiological processes. This article summarizes recent advances in flatfish genomics research in Europe. We focus on the new generation sequencing technologies, which can produce a massive amount of DNA sequencing data, and discuss their potentials and applications for de novo genome sequencing and transcriptome analysis. The relevance of these methods in nutrigenomics and foodomics approaches for the production of healthy animals, as well as high quality and safety products for the consumer, is also briefly discussed.

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The Molecular and Endocrine Basis of Flatfish Metamorphosis

Cited by 68 publications

References 134 publications

Genetic population structure in flatfishes and potential impact of aquaculture and stock enhancement on wild populations in Europe

Genetic population structure in flatfishes and potential impact of aquaculture and stock enhancement on wild populations in Europe

Transcriptomic Characterization of the Larval Stage in Gilthead Seabream (Sparus aurata) by 454 Pyrosequencing

Advances in genomics for flatfish aquaculture

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