The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit

Webster, Dan E.; Suver, Christine; Doerr, Megan; Mounts, Erin; Domenico, Lisa; Petrie, Tracy; Leachman, Sancy A.; Trister, Andrew D.; Bot, Brian M.

doi:10.1038/sdata.2017.5

Cited by 69 publications

(43 citation statements)

References 14 publications

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“…[13][14][15][16] Additionally, 73% of participants in our study were willing to share data with outside researchers which is similar to other ResearchKit studies (67-78%). 13,15,16 Higher engagement and willingness to share data may be a result of our unique study population of expectant mothers bringing their baby into the world, during a limited, circumscribed temporal window. We may also have lower drop-off because women receive other useful information through the WebMD pregnancy app and may therefore be less likely to delete it and withdraw from the study.…”

Section: Commentsupporting

confidence: 79%

The Healthy Pregnancy Research Program: Transforming Pregnancy Research Through a ResearchKit App

Radin

Steinhubl

et al. 2018

Preprint

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Short Title: Pregnancy ResearchKit App 2 Background. Although maternal morbidity and mortality in the United States is among the worst of developed countries, pregnant women have been under-represented in research studies, resulting in deficiencies in evidence-based guidance for treatment. There are over two billion smartphone users worldwide, enabling researchers to easily and cheaply conduct extremely large-scale research studies through smartphone apps, especially among pregnant women in whom app use is exceptionally high, predominantly as an information conduit Objective: We aim to improve our understanding of factors that promote a healthy pregnancy for both the mother and developing fetus through the large-scale and simplified collection of participant-generated data.Study Design. We developed the first pregnancy research app that is embedded within an existing, popular pregnancy app for self-management and education of expectant mothers. Our research app is used to collect a combination of survey and sensor generated data from pregnant women living in the U.S. Results. From the study's launch onMarch 16, 2017 through December 17, 2017, we have enrolled 2,058 participants from all 50 states. Our study population is diverse geographically and demographically, and fairly representative of U.S. population averages. We have collected 14,045 individual surveys and 11,669 days of sleep, activity, blood pressure and heart rate measurements during this time. On average, women stayed engaged in the study for 64 days and 48 percent who reached their due date filled out the final outcome survey. Conclusion. During the first nine months of the deployment of this unique program of ongoing research in pregnancy, we demonstrated the potential for a smartphone-based research platform to capture an ever-expanding array of longitudinal, objective and subjective participantgenerated data from a continuously growing and diverse population of pregnant women. Clinical Trials Registration: ClinicalTrials.gov Identifier: NCT03085875

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Section: Commentsupporting

confidence: 79%

The Healthy Pregnancy Research Program: Transforming Pregnancy Research Through a ResearchKit App

Radin

Steinhubl

et al. 2018

Preprint

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“…[105][106][107] Moreover, Apps could have a high user engagement and a positive persuasive impact on the user's attitude. 108 The effectiveness of skin health interventions by smart phones via Apps and messages to promote sun protection and skin examination are investigated in further studies [109][110][111] and are likely to replace several print-based health promotion campaigns in the future.…”

Section: Discussionmentioning

confidence: 99%

Primary prevention of keratinocyte carcinoma among outdoor workers, the general population and medical professionals: a systematic review updated for 2019

Ziehfreund

Schuster

Zink

2019

Acad Dermatol Venereol

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Worldwide 2–3 million cases of keratinocyte carcinoma (KC) are diagnosed annually. Sun‐related knowledge is essential for adequate protection against solar ultraviolet radiation (UVR), the main risk factor for KC. The goal was (i) to provide an updated overview of primary prevention against KC including skin cancer‐related knowledge, attitudes and sun protection behaviour (SPB) of outdoor workers, the general population and medical professionals as well as (ii) to evaluate the effectiveness and acceptability of sun protection programmes. We conducted a systematic review of articles indexed for MEDLINE on PubMed using selected MeSH terms and keywords related to the studied topic as well as an extensive hand search of publications between 1 January 2012 and 31 December 2018. We identified 51 relevant cross‐sectional studies and 22 interventional studies. Sun‐related knowledge and attitude showed substantial differences with some alarming results, including people who had not even heard about skin cancer before. Reported SPB varied enormously between the included studies, with none of the studies providing an overall sufficient SPB in their examined sun protection measures. However, sun protection programmes using new technologies seem to have great potential to increase sun‐related knowledge and SPB. In countries worldwide, particularly in those where KC is not yet a public health issue, UVR protection should be promoted by healthcare institutions and authorities, politicians, cancer foundations and dermatologists to increase awareness as well as SPB and to decrease the worldwide burden of KC.

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“…For example, by removing the threat of sunburn, pigmentation-enhancing agents may disinhibit unprotected UVR exposure in some patients, offsetting chemopreventive benefits. Recruitment, characterization, and monitoring of participants could be augmented and accelerated by the use of smart phone apps, such as Mole Mapper (using the Apple ResearchKit; Apple Inc, Cupertino, CA), 157 which currently helps individuals track the size and appearance of their nevi over time. Mole Mapper offers participants the opportunity to share their data with researchers under an institutional review board-approved protocol.…”

Section: Phase 3 Trialsmentioning

confidence: 99%

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

Jeter

Bowles

Curiel‐Lewandrowski

et al. 2018

Cancer

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Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival. As these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of the disease. Now is the time to apply that knowledge towards the design and clinical evaluation of new chemoprevention agents. Melanoma chemoprevention has the potential to dramatically reduce both the morbidity and high costs associated with treating patients with metastatic disease. In this work, scientific and clinical melanoma experts from the national Melanoma Prevention Working Group comprised of National Cancer Trials Network (NCTN) participants, discuss research aimed at discovering and developing (or re-purposing) drugs and natural products for the prevention of melanoma, and propose an updated pipeline for translating the most promising agents into the clinic. The mechanism of action, pre-clinical data, epidemiological evidence and results of available clinical trials are discussed for each class of compounds. Selected keratinocyte carcinoma chemoprevention studies are also considered, and a rationale for their inclusion is presented. These data are summarized in a table that lists the type and level of evidence available for each class of agents. Also included in the discussion is an assessment of additional research necessary and likelihood that a given compound might be a suitable candidate for a Phase III clinical trial within the next 5 years.

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The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit

Cited by 69 publications

References 14 publications

The Healthy Pregnancy Research Program: Transforming Pregnancy Research Through a ResearchKit App

The Healthy Pregnancy Research Program: Transforming Pregnancy Research Through a ResearchKit App

Primary prevention of keratinocyte carcinoma among outdoor workers, the general population and medical professionals: a systematic review updated for 2019

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

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