The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance

Watanabe, Kazuko; Ozono, Satoru; Nishiyama, Kozaburo; Saito, Shigeru; Tonosaki, Keiichi; Fujita, Masafumi; Onozuka, Minoru

doi:10.1016/s0166-4328(01)00268-6

Cited by 94 publications

(105 citation statements)

References 37 publications

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“…Yet the behaviors of the mice of extraction groups in the pool showed obviously unpurposed. These results confirmed that the mice of extraction groups had impaired memory for the location of the hidden platform in the water maze, which was similar to the previous studies [20].…”

Section: Molarless Mice Exhibit a Decreased Spatial Learning Ability supporting

confidence: 92%

Behavioral impairments and changes of nitric oxide and inducible nitric oxide synthase in the brains of molarless KM mice

Pang¹,

Hu²,

Li³

et al. 2015

Behavioural Brain Research

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Section: Molarless Mice Exhibit a Decreased Spatial Learning Ability supporting

confidence: 92%

Behavioral impairments and changes of nitric oxide and inducible nitric oxide synthase in the brains of molarless KM mice

Pang¹,

Hu²,

Li³

et al. 2015

Behavioural Brain Research

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“…GFAP-immunoreactive cells were quantitatively analyzed as previously described 5,7,14,15) . We counted medium and large cells that were clear and round in the left hippocampus (Bregma: -2.18 mm using the atlas of Franklin and Paxinos 16) ) on each section using a 20× microscope objective.…”

Section: Methodsmentioning

confidence: 99%

The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus

Kubo¹,

Saitoh

Kogaya³

et al. 2008

Okajimas Folia Anat. Jpn.

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Summary:The bite raised condition decreases the number of neurons and increases the amount of glial fibrillary acidic protein in the hippocampus of aged SAMP8 mice. In the present study, we examined whether these effects differ between the dorsal and ventral hippocampus. In bite-raised SAMP8 mice, the number of neurons was significantly lower in the hippocampal CA1 and dentate gyrus (DG) subfields compared to control mice. In the bite raised condition, the number of neurons was significantly lower in both the dorsal and ventral CA3 subfields, and the number of glial fibrillary acidic proteinlabeled astrocytes was increased in the CA1, CA3, and DG subfields, compared to control mice. These data suggest that in aged SAMP8 mice, the bite-raised condition enhanced aging processes in both the dorsal and ventral hippocampus.

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“…The Morris water maze test is a sensitive behavioral assay for forebrain abnormalities (Morris 1984). Morris water maze training was performed as described previously (Onozuka et al 1999;Watanabe et al 2002;Kubo et al 2005). A stainless steel tank with 90 cm in diameter and 30 cm in depth was filled with water (approximately 26°C) to a height of 16 cm, and the water surface was covered with floating polystyrene foam granules (approximately 2 mm in diameter).…”

Section: Morris Water Maze Leaning Testmentioning

confidence: 99%

Occlusal Disharmony Transiently Impairs Learning and Memory in the Mouse by Increasing Dynorphin A Levels in the Amygdala

Yamada

Ono

Kubo

et al. 2013

Tohoku J. Exp. Med.

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Occlusal disharmony sometimes causes not only stiffness of neck but also psychiatric depression, suggesting that the condition of oral cavity may affect the central nervous system. Dynorphin A is an endogenous opioid peptide that specifically binds the κ-opioid receptor and has a protective role against stress. Dynorphinergic nervous system is intensely distributed in the amygdala and hippocampus that are coping areas with stress. As a model of malocclusion, we placed dental resin on the molars to increase the occlusal vertical dimension (bite-raise). After various survival times, we analyzed the amygdala and hippocampus by immunohistochemistry and immunosorbent assay (ELISA). Furthermore, the effects on learning and memory were assessed by Morris water maze test. In the amygdala, the levels of dynorphin A were increased on the 1st day after increasing the vertical dimension as indicated by immunohistochemical and ELISA assessments. The levels of dynorphin A returned to control levels on the 5th day. In the hippocampus, there were no noticeable changes in dynorphin A levels. The water maze test indicated that increasing the vertical dimension caused longer escape latency times on the 3rd day compared to those of sham-operated group. However, the bite-raised mice treated with a dynorphin antagonist, nor-binaltorphimine, showed similar escape latency times to the times of sham-operated group, even on the 3rd day. These results suggest that occlusal disharmony causes stress resulting in a transient increase of dynorphin A levels at least in the amygdala and that the increased dynorphin A levels transiently impair learning and memory.

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The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance

Cited by 94 publications

References 37 publications

Behavioral impairments and changes of nitric oxide and inducible nitric oxide synthase in the brains of molarless KM mice

Behavioral impairments and changes of nitric oxide and inducible nitric oxide synthase in the brains of molarless KM mice

The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus

Occlusal Disharmony Transiently Impairs Learning and Memory in the Mouse by Increasing Dynorphin A Levels in the Amygdala

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