1990
DOI: 10.1200/jco.1990.8.1.185
|View full text |Cite
|
Sign up to set email alerts
|

The Modulation of Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma

Abstract: The authorship of the report "The Modulation of Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma: A Randomized Phase III Trial," published in the October 1989 issue (J Clin Oncol 7:1419–1426, 1989) should have read: "by the Gastrointestinal Tumor Study Group." The following appendix should also have appeared at the end of the report:

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

2
8
0
1

Year Published

1990
1990
2003
2003

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 66 publications
(11 citation statements)
references
References 9 publications
2
8
0
1
Order By: Relevance
“…There was no necessity for dose reductions and 97% of treatments were given as planned. The response rate seen was in accord with those obtained in other colorectal cancer studies (De Gramont et al, 1988;Petrelli et al, 1988;Petrelli et al, 1989;Poon et al, 1989;Machover et al, 1986;Erlichman et al, 1988;Arbuck, 1989), suggesting similar efficacy, although clearly a phase III trial would be required to confirm this. The response rate in gastric cancers is comparable to that described for more toxic combination regimens (Macdonald et al, 1979;Gastrointestinal Tumor Study Group 1982;Douglass et al, 1984) and considerably better than that reported previously for 5-fluourouracil and folinic acid (Arbuck et al, 1987;Berenberg et al, 1989).…”
Section: Discussionsupporting
confidence: 87%
See 2 more Smart Citations
“…There was no necessity for dose reductions and 97% of treatments were given as planned. The response rate seen was in accord with those obtained in other colorectal cancer studies (De Gramont et al, 1988;Petrelli et al, 1988;Petrelli et al, 1989;Poon et al, 1989;Machover et al, 1986;Erlichman et al, 1988;Arbuck, 1989), suggesting similar efficacy, although clearly a phase III trial would be required to confirm this. The response rate in gastric cancers is comparable to that described for more toxic combination regimens (Macdonald et al, 1979;Gastrointestinal Tumor Study Group 1982;Douglass et al, 1984) and considerably better than that reported previously for 5-fluourouracil and folinic acid (Arbuck et al, 1987;Berenberg et al, 1989).…”
Section: Discussionsupporting
confidence: 87%
“…These reports also describe toxicity different from that produced by 5-fluorouracil alone: Regimens using weekly bolus injections are reported as frequently causing diarrhoea (in 22-80% of patients) with occasional toxic deaths from this (Petrelli et al, 1988;Petrelli et al, 1989), whilst those employing daily injections for one week in four report both diarrhoea and oral mucositis -the latter in 40-80% of patients (Machover et al, 1986;Erlichman et al, 1988;Poon et al, 1989 …”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Treatment with a combination of 5-fluorouracil (5-FU) and leucovorin has been shown to result in an objective response in approximately 30 to 40% of patients with proven survival benefit (Poon et al, 1989;Petrelli et al, 1989). Similar, or higher, response rates, including some complete responses, are now also being reported in patients treated with 5-FU in combination with interferon-alpha (Wadler et al, 1989;Wadler & Wiernik, 1990).…”
mentioning
confidence: 75%
“…The treatment appears to be associated with survival benefit in comparative studies (Poon et al, 1989;Petrelli et al, 1989) and, hence, the benefit may be very considerable in patients who respond to treatment.…”
Section: Discussionmentioning
confidence: 99%