The ModifiedGlasgow Prognostic Score and Survival in Colorectal Cancer: A Pooled Analysis of the Literature

Petrelli, Fausto; Barni, Sandro; Coinu, Andrea; Bertocchi, Paola; Borgonovo, Karen; Cabiddu, Mary; Ghilardi, Mara; Zaniboni, Alberto

doi:10.2174/1574887110666150317121413

Cited by 38 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of studies have also found similar results for the prognostic role CAR or GPS in various types of cancers. [7][8][9][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] This highlighted the general prognostic role of these two inflammation-based scores in malignancies.…”

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

Chen

Liu

Feng

et al. 2020

CMAR

View full text Add to dashboard Cite

The prognostic significance of inflammation-based biomarkers for neuroblastoma (NB) has not been investigated before. The aim of this study was to evaluate the prognostic value of pre-treatment inflammation biomarkers in children patients with NB. Patients and Methods: Patients diagnosed with NB from 2008 to 2016 in our institution were enrolled in this study. The clinical data and survival outcomes were retrospectively reviewed. Inflammation biomarkers or scores including C-reactive protein (CRP), albumin (ALB), Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), high-sensitivity modified Glasgow Prognostic Score (Hs-mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and system inflammation index (SII) were tested in this study. Univariate and multivariate survival analyses were performed to assess the prognostic value of these inflammation indicators for overall survival (OS) of children with NB. Kaplan-Meier survival curves were also conducted. Results: A total of 70 children diagnosed with neuroblastoma were enrolled in this study. NLR, PLR, LMR and SII were found to be not predictive of OS for NB patients. However, CRP, ALB, GPS and CAR were significantly associated with OS of NB patients. Multivariate analysis adjusting for age, sex, histology, tumor size, tumor stage and metastasis revealed that ALB, CAR, GPS and Hs-mGPS were significantly associated with OS of NB patients. Receiver operating characteristic (ROC) curves and Akaike Information Criterion (AIC) analyses revealed that Hs-mGPS is superior to other inflammation biomarkers in predicting OS of NB patients. Subgroup survival analysis for immature NB patients revealed similar results. Conclusion: Hs-mGPS is an effective prognostic factor for OS of patients with NB and is promising to be used as a factor for risk stratification and an indicator for more aggressive therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

Chen

Liu

Feng

et al. 2020

CMAR

View full text Add to dashboard Cite

show abstract

“…The CRP/ALB ratio was calculated from the preoperative blood samples by dividing the serum CRP level by the serum ALB level. The mGPS was defined according to the methods of a previous report (Petrelli et al 2015 ), using the combination of the serum CRP and ALB levels: patients with a CRP level of <1.0 mg/dl were allocated a score of 0; those in whom the CRP and ALB levels were ≥1.0 mg/dl and ≥3.5 g/dl, respectively, were allocated a score of 1; and those in whom the CRP and ALB levels were ≥1.0 mg/dl and ALB < 3.5 g/dl, respectively, were allocated a score of 2. The neutrophil to lymphocyte ratio (NLR) was calculated from a blood sample by dividing the absolute neutrophil count by the absolute lymphocyte count.…”

Section: Methodsmentioning

confidence: 99%

The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer

et al. 2016

View full text Add to dashboard Cite

Inflammation has been reported to play an important role in cancer progression and various inflammatory markers have been reported to be useful prognostic markers. The aim of this retrospective study was to evaluate the significance of the C-reactive protein to albumin (CRP/ALB) ratio in colorectal cancer patients who received palliative chemotherapy. We performed a retrospective review of 99 patients who underwent palliative chemotherapy for unresectable colorectal cancer between 2005 and 2010. The cutoff value of the CRP/ALB ratio was determined based on a receiver operating characteristics curve analysis. The relationship between the CRP/ALB ratio and survival was assessed. The cutoff value for the CRP/ALB ratio was 0.183. The high pretreatment CRP/ALB ratio group showed significantly worse overall survival. Patients with a high pretreatment CRP/ALB ratio and in whom the CRP/ALB ratio normalized after chemotherapy tended to have better overall survival than those in whom both the pretreatment and posttreatment CRP/ALB ratios were high. The CRP/ALB ratio is a useful marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer.

show abstract

“…CRC-ben 9 vizsgálat (n = 2227) metaanalízise alapján az emelkedett mGPS rövidebb teljes túléléssel társult (HR 1,69 [95%-os CI 1,4-2,04], p<0,00001) [22].…”

Section: Eredményekunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

View full text Add to dashboard Cite

A szérumalbuminszint csökkenése figyelhető meg gyulladásos folyamatokban. A helyileg előrehaladott vagy áttétes rosszindulatú daganatokban a szérumalbuminszint ugyancsak csökken, az alultápláltság fennállásától függetlenül. A csökkent albuminszint befolyásolhatja a terápia eredményeit is (például gyógyszerek farmakokinetikája, mellékha-tások mértéke). Kiterjedt szakirodalmi adat és gyakorlati tapasztalat bizonyítja a táplálásterápiában részesülő pácien-sek jobb prognózisát. A szerzők a fontosabb szakirodalmi adatok alapján összefoglalják azon vizsgálatokat, melyek a kiindulási szérumalbuminszint és a rosszindulatú daganatos betegségek prognózisa közötti szoros összefüggést feltárták. Orv Hetil. 2018; 159(3): 96-106. Kulcsszavak: albumin, rosszindulatú daganatok, prognózis Prognostic importance of albumin in oncologyDiminished serum albumin level can be observed in inflammatory processes. Serum albumin level also reduces -irrespective of the presence of malnutrition -in locally advanced or metastatic malignancies. Low serum albumin level may have an influence also on the results of anticancer therapy (e.g., drug pharmacokinetics, adverse drug reactions). Extensive data of the literature and empirical experience prove the better prognosis of patients involved in nutritional therapy. Based on the most relevent data of the literature, the authors summarize the studies which have revealed the close correlation between the baseline serum albumin level and the prognosis of malignant diseases. Rövidítések ALI = (advanced lung cancer inflammation index) előrehala-dott tüdőrák index; APACHE = (acute physiology and chronic health evaluation) heveny élettani és idült egészség értékelés; BC = (breast cancer) emlőrák; BMI = (body mass index) testtömegindex (kg/m 2 ); CI = konfidenciaintervallum; CRC = (colorectal cancer) vastag-és végbélrák; CRP = C-reaktív protein; CRPC = (castration-resistant prostate cancer) kasztráció-rezisztens prostatarák; CSS = (cancer specific survival) daganatspecifikus túlélés; DFS = (disease-free survival) betegségmentes túlélés; DNS = dezoxiribonukleinsav; DSS = (disease-specific survival) betegségspecifikus túlélés; GPS = (Glasgow Prognostic Score) Glasgow prognosztikai pontrendszer; HCC = (hepatocellular carcinoma) primer májrák; HR = (hazard ratio) kockázati hányados; IL = interleukin; IMA = ischaemiamódosított albumin; IPI = (inflammatory prognostic index) gyulladásos prognosztikai index; KPS = Karnofsky Performance Status; LDH = (lactate dehydrogenase) laktátdehidrogenáz; LMR = (lymphocyte-monocyte ratio) abszolút lymphocyta-monocyta arány; mGPS = (modified Glasgow Prognostic Score) módosí-tott Glasgow prognosztikai pontrendszer; mGPS 0, 1, 2 = a módosított Glasgow prognosztikai pontrendszer értékei 0, 1, 2; MSKCC = Memorial Sloan Kettering Cancer Center; nabpaclitaxel = nanopartikuláris albuminhoz kötött paclitaxel; NLR = (neutrophil-lymphocyte ratio) abszolút neutrophillym phocyta arány; NRS = (nutritional risk screening) tápláltsá-gi kockázatszűrés; NSCLC = (non-small cell lung cancer) nem...

show abstract

The ModifiedGlasgow Prognostic Score and Survival in Colorectal Cancer: A Pooled Analysis of the Literature

Abstract: A high m-GPS is associated with poor OS in colorectal cancer. The m-GPS is a cheap and easily evaluable biomarker, and its incorporation into known prognostic scores for clinical decision making warrants further investigation in this setting.

Cited by 38 publications

References 0 publications

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer

Az albumin prognosztikai jelentősége az onkológiában

Contact Info

Product

Resources

About