In this paper, we present a further generalization of the biperiodic Fibonacci quaternions and octonions. We give the generating function, the Binet formula, and some basic properties of these quaternions and octonions. The results of this paper not only give a generalization of the bi-periodic Fibonacci quaternions and octonions, but also include new results such as the matrix representation and the norm value of the generalized bi-periodic Fibonacci quaternions.2000 Mathematics Subject Classification. 11B39, 05A15, 11R52.