The modern role of smartphones in analytical chemistry

Rezazadeh, Maryam; Seidi, Shahram; Lid, Marthe; Pedersen‐Bjergaard, Stig; Yamini, Yadollah

doi:10.1016/j.trac.2019.06.019

Cited by 167 publications

(66 citation statements)

References 60 publications

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“…Screening LFIAs are relatively cheap, can be performed on-site, and are fast, and the readout of an LFIA can be performed visually or, as many developed lately, with the use of a smartphone camera, for a more reliable and semi-quantitative result [ 13 ]. Smartphones offer a variety of opportunities for user-friendly diagnostics, providing easy-to-read results, wireless data transfer to the cloud, and, most importantly for on-site testing, time and location data of the sampling [ 14 ]. Focusing solely on food safety, Rateni et al recorded 27 studies, in only 5 years, between 2012 and 2017, that used smartphone-based diagnostics for food safety analysis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Direct analysis of lateral flow immunoassays for deoxynivalenol using electrospray ionization mass spectrometry

2020

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Lateral flow immunoassays (LFIAs) are widely used for rapid food safety screening analysis. Thanks to simplified protocols and smartphone readouts, LFIAs are expected to be increasingly used on-site, even by non-experts. As a typical follow-up in EU regulatory settings, suspect samples are sent to laboratories for confirmatory analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, re-analysis by LC-MS/MS is laborious and time-consuming. In this work, an identification LFIA (ID-LFIA) approach followed by quadrupole-orbitrap MS or triple quadrupole MS/MS analysis is presented. As a proof of concept, a dedicated ID-LFIA strip was developed for the mycotoxin deoxynivalenol (DON) following its initial screening by a commercial smartphone LFIA. The ID-LFIA strip can be simply immersed in the same sample extract used for the smartphone LFIA screening, and next, DON is retrieved from the monoclonal antibody with a dissociation solution consisting of methanol/ammonia. The solution thus obtained was analyzed directly in MS in order to rapidly confirm the presence of DON and any cross-reacting species. The protocol developed is capable of coping with severe ion suppression caused by LFIA buffers and nitrocellulose substrate residues. Initial analysis of blank, spiked, and incurred samples showed that the newly developed ID-LFIA-MS method was able to confirm the presence or absence of mycotoxins in the samples previously analyzed by LFIA and also differentiate between DON and DON 3-glucoside yielding the positive screening result. The concept and technique developed are envisaged to complement on-site screening and confirmation of any low molecular weight contaminant in future food control frameworks.

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Section: Introductionmentioning

confidence: 99%

Direct analysis of lateral flow immunoassays for deoxynivalenol using electrospray ionization mass spectrometry

2020

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“…Recently smartphones have been used e.g., for colorimetric detection of nitrite [8], spectrometric detection of ascorbic acid [9] or colorimetric assay of uric acid and glucose [10]. Several review papers summarizing smartphone based bioanalytical and diagnosis applications have been published recently [11, 12, 13].…”

Section: Resultsmentioning

confidence: 99%

Smartphone-based image analysis for evaluation of magnetic textile solid phase extraction of colored compounds

Šafařı́k

Baldíková

Procházková

et al. 2019

Heliyon

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Novel modern easily feasible methods for direct evaluation of a new, simple preconcentration analytical procedure have been developed. Two types of smartphone image analysis applications (ON Color Measure and Color Lab) were evaluated to obtain RGB and HSV color spaces data for the quantification of Magnetic textile solid phase extraction of colored compounds (e.g. water-soluble organic dyes). Both direct measurement of color spaces values via the smartphone camera and image analysis of the photograph can be used successfully. The obtained data were similar to those obtained by previously examined professional ImageJ software. The saturation (S) values of the HSV color space are directly proportional to the concentrations of the analyzed dye.

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“…In the modern world, people are highly dependent on their phones. Smartphones have endless possibilities, from monitoring our biorhythm to navigating us with accurate mapping [ 28 ]. One of the emerging possibilities of smartphone use is monitoring food quality and safety [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

From Smartphone Lateral Flow Immunoassay Screening to Direct MS Analysis: Development and Validation of a Semi-Quantitative Direct Analysis in Real-Time Mass Spectrometric (DART-MS) Approach to the Analysis of Deoxynivalenol

Geballa-Koukoula

Gerssen

Nielen

2021

Sensors

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In current food safety monitoring, lateral flow immunoassays (LFIAs) are widely used for rapid food contaminant screening. Recent advances include smartphone readouts, offering semi-quantitative analysis of LFIAs with time, location, and data transfer in case of on-site testing. Following the screening, the next step in the EU regulations is confirmation by, e.g., liquid chromatography-tandem mass spectrometry (LC-MS/MS). In this work, using direct analysis in real time ambient ionization and triple quadrupole MS/MS (DART-QqQ-MS/MS), we achieved rapid confirmation of the identity of the substance(s) causing the LFIA result. In the workflow proposed, an individual performs the (on-site) smartphone LFIA screening, and when the result is suspect, an identification LFIA (ID-LFIA) strip is developed with the same sample extract. The ID-LFIA can be dissociated and rapidly analyzed in a control laboratory with DART-QqQ-MS/MS. The ID-LFIA consists of multiple lines of monoclonal antibodies against the mycotoxin deoxynivalenol, acting as a bioaffinity trap. The ID-LFIA/DART-QqQ-MS/MS approach has been developed and validated, along with the screening smartphone LFIA, and has demonstrated its applicability by analyzing incurred and spiked samples. The developed approach has been critically compared with our previous direct electrospray ionization MS method and was found to provide highly complementary information on the total deoxynivalenol contamination in the sample.

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The modern role of smartphones in analytical chemistry

Cited by 167 publications

References 60 publications

Direct analysis of lateral flow immunoassays for deoxynivalenol using electrospray ionization mass spectrometry

Direct analysis of lateral flow immunoassays for deoxynivalenol using electrospray ionization mass spectrometry

Smartphone-based image analysis for evaluation of magnetic textile solid phase extraction of colored compounds

From Smartphone Lateral Flow Immunoassay Screening to Direct MS Analysis: Development and Validation of a Semi-Quantitative Direct Analysis in Real-Time Mass Spectrometric (DART-MS) Approach to the Analysis of Deoxynivalenol

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