The modern concept of the regulatory role of peptides of the glyproline family in the correction of hemostasis system function during development of diabetes mellitus

Lyapina, L. A.; Myasoedov, N. F.; Григорьева, М.Е.; Shubina, T. A.; Андреева, Л. А.

doi:10.1134/s1062359013040109

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…The amount of peptides with a molecular weight of 200-1000 g/mol (comprising peptides with approximately 2-5 amino acids) were similar in the two fish protein hydrolysates, and none of the diets contained measurable amounts of long-chain n-3 PUFA. Both herring and salmon hydrolysates tested in the present study contained motifs with reported hypocholesterolemic and/or antidiabetic effects (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) . To our knowledge, this is the first study testing dietary hydrolysed fish protein with identified bioactive motifs with hypocholesterolemic and antidiabetic activities in obese rats.…”

Section: Discussionmentioning

confidence: 92%

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats

et al. 2016

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The world's fisheries and aquaculture industries produce vast amounts of protein-containing by-products that can be enzymatically hydrolysed to smaller peptides and possibly be used as additives to functional foods and nutraceuticals targeted for patients with obesity-related metabolic disorders. To investigate the effects of fish protein hydrolysates on markers of metabolic disorders, obese Zucker fa/fa rats consumed diets with 75 % of protein from casein/whey (CAS) and 25 % from herring (HER) or salmon (SAL) protein hydrolysate from rest raw material, or 100 % protein from CAS for 4 weeks. The fatty acid compositions were similar in the experimental diets, and none of them contained any long-chain n-3 PUFA. Ratios of lysine:arginine and methionine:glycine were lower in HER and SAL diets when compared with CAS, and taurine was detected only in fish protein hydrolysate diets. Motifs with reported hypocholesterolemic or antidiabetic activities were identified in both fish protein hydrolysates. Rats fed HER diet had lower serum HDL-cholesterol and LDL-cholesterol, and higher serum TAG, MUFA and n-3:n-6 PUFA ratio compared with CAS-fed rats. SAL rats gained more weight and had better postprandial glucose regulation compared with CAS rats. Serum lipids and fatty acids were only marginally affected by SAL, but adipose tissue contained less total SFA and more total n-3 PUFA when compared with CAS. To conclude, diets containing hydrolysed rest raw material from herring or salmon proteins may affect growth, lipid metabolism, postprandial glucose regulation and fatty acid composition in serum and adipose tissue in obese Zucker rats.

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Section: Discussionmentioning

confidence: 92%

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats

et al. 2016

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“…It was reported that the synthetic di‐ and tripeptides containing glycine, such as glycine–leucine (reverse in N and C‐terminal of amino acid in comparison with peptide Hannaneh), are a strong stimulus for GLP‐1 and are involved in a two sensory mechanism (PEPT1 and calcium‐sensing) receptor. Also, proline‐containing di‐ and tripeptides can cause a prophylactic antidiabetic effects in experimental insulin‐dependent diabetes mellitus in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Leu and its small peptides are known to stimulate insulin secretion from pancreatic β‐cells by serving as metabolic fuel and regulating cell metabolism. Furthermore, Leu peptides regulate the expression of key metabolic genes in β‐cells as a new opportunity for prevention of islet dysfunction and diabetes. The peptides of the glyproline family show various bioactivities, and the linear glyproline peptides are relatively stable ( t 1/2 of Pro‐Gly‐Pro is >24 h).…”

Section: Introductionmentioning

confidence: 99%

Leucine–glycine and carnosine dipeptides prevent diabetes induced by multiple low‐doses of streptozotocin in an experimental model of adult mice

Vahdatpour

Nokhodchi

Zakeri–Milani

et al. 2019

J of Diabetes Invest

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Aims/Introduction Peptides are considered to be quasi‐hormones and effective molecules for regulation of the cells function and prevention of metabolic disorders. Di‐ and tripeptides gastrointestinal absorption ability have been proposed to prevent diabetes progression. Materials and Methods Small peptides with different sequences of specific amino acids were synthesized based on a solid phase peptide synthesis protocol, and carnosine (A) and glutathione were examined for the prevention of diabetes induced by multiple low‐doses of streptozotocin in mice. Results The peptides A, Leu‐Gly (D) and Pro‐Pro showed preventive effects on blood glucose elevation and impairment of the signaling and performance of β‐cells. The β‐cell function assessed by immunofluorescence and blood glucose level in mice exposed to diabetes treated by the peptides A and D was similar to the normal mice. The peptide D prevented bodyweight loss caused by diabetes induction. The use of D and A peptides dramatically prevented the incidence of disruption in β‐cells signaling by maintaining the natural balance of intracellular Akt‐2 and cyclic adenosine monophosphate. Conclusions The results proved that peptide D (Leu‐Gly), named Hannaneh, inhibits the bodyweight loss caused by diabetes induction. The Hannaneh and carnosine dipeptides, with preservation of normal β‐cell signaling and anti dipeptidyl peptidase‐4 activity, prevented blood glucose increases in mice at risk of diabetes. These dipeptides might be regarded as the pharmaceutical agents for the prevention of diabetes.

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“…Besides, the bioactivities of peptides are considered to be related to the amino acid composition and sequence of peptides . It has been shown that proline‐containing peptides reveal the hypoglycemic and hypolipidemic effects in experimental models of diabetes mellitus . Milk‐derived tripeptides containing proline improves insulin sensitivity and inhibits adipose inflammation in diet‐induced obese mice .…”

Section: Discussionmentioning

confidence: 99%

Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling

Song

Wang

et al. 2016

Molecular Nutrition Food Res

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The modern concept of the regulatory role of peptides of the glyproline family in the correction of hemostasis system function during development of diabetes mellitus

Cited by 15 publications

References 25 publications

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats

Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats

Leucine–glycine and carnosine dipeptides prevent diabetes induced by multiple low‐doses of streptozotocin in an experimental model of adult mice

Casein glycomacropeptide‐derived peptide IPPKKNQDKTE ameliorates high glucose‐induced insulin resistance in HepG2 cells via activation of AMPK signaling

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