The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling

Iselius, Lennart; Williams, William V.

doi:10.1007/bf00293877

Cited by 22 publications

(7 citation statements)

References 9 publications

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“…The Danish study 9 estimated the heritability of the disease to be about 90%, whereas the Australian study 10 reported the heritability of about 80%. A similar estimate of heritability (87%) was obtained from re‐analyses of the census study conducted by Lomholt on the Faroe Islands 20 . We found a slightly lower heritability (66%) of psoriasis.…”

Section: Discussionsupporting

confidence: 85%

Psoriasis in Norwegian twins: contribution of genetic and environmental effects

Grjibovski

Olsen

Magnus

et al. 2007

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 85%

Psoriasis in Norwegian twins: contribution of genetic and environmental effects

Grjibovski

Olsen

Magnus

et al. 2007

Acad Dermatol Venereol

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“…Both psoriasis and PsA show high rates of familial aggregation, suggesting that both disorders have a strong genetic basis (20)(21)(22)(23)(24)(25). In a landmark study by Moll & Wright (20), the prevalence of PsA among first-degree relatives was 49 times higher than the prevalence in the general population.…”

Section: Genetic Factorsmentioning

confidence: 94%

Current Concepts in Psoriatic Arthritis: Pathogenesis and Management

Vlam¹,

Gottlieb²,

Mease³

2014

Acta Derm Venerol

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Psoriatic arthritis occurs in a subset of psoriasis patients and is therefore commonly encountered in dermatology practice. Although its exact pathogenesis is unknown, psoriatic arthritis is thought to share common mechanisms with psoriatic skin symptoms. Innate and adaptive immune responses are abnormally activated in psoriasis and may acquire the ability to attack peripheral joints and other sites following an environmental trigger (e.g. mechanical stress, trauma, infection) in genetically susceptible patients. The increased cardiovascular risk inherent in psoriasis appears further enhanced in psoriatic arthritis, likely reflecting the overall burden of systemic inflammation contributing to atherogenic processes. Basic research and clinical trials have suggested that tumour necrosis factor is important in psoriatic arthritis pathophysiology, and accumulating evidence suggests that Th17 cells and interleukin-17A may also be important. Basic research and clinical trials inform our understanding of psoriatic arthritis pathophysiology and, in turn, help dermatologists to make better treatment decisions.

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“…1,7 A multi-factorial inheritance which involves several genes has been suggested 8,9 but evidence for a major gene has also been proposed. 10 We have earlier shown in a population genetic study that a recessive mode of inheritance is compatible with distribution among first degree relatives with a high gene frequency. 11 With a recessive mode and a high gene frequency, a number of families will appear with a pseudo-dominant inheritance, ie one parent homozygous and the other heterozygous, giving a dominant-like inheritance.…”

Section: Introductionmentioning

confidence: 94%

Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden

et al. 1999

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We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.

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The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling

Cited by 22 publications

References 9 publications

Psoriasis in Norwegian twins: contribution of genetic and environmental effects

Psoriasis in Norwegian twins: contribution of genetic and environmental effects

Current Concepts in Psoriatic Arthritis: Pathogenesis and Management

Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden

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