The MNS16A VNTR polymorphism of the TERT gene in bladder cancer

Abstract

I n d e x e d i n P u b M e d , W e b o f S c i e n c e a n d S c o p u s Yasemin Yuyucu Karabulut, et al.; The role of COL6A1 and PD-1 expressions in renal cell carcinoma.

Analysis of MNS16A VNTR polymorphic sequence variations of the TERT gene and associated risk for development of bladder cancer

“…No single clinical or pathological parameter such as smoking status, histological type, tumor stage, or geographic area were found to be associated with different genotypes of MNS16A ( p > 0.5), although age < 50 years approached statistical significance ( p = 0.052). These results are consistent with other studies on breast cancer conducted by Hashemi et al [31] and bladder cancer conducted by Diler et al [26] where all clinical and pathological parameters showed no association.…”

“…The frequency of MNS16A in the current study showed similarities and discrepancies with other ethnic populations, as depicted in Table 4. The frequencies of different alleles of MNS16A observed for cases in our population correlated most closely with studies conducted on different cancers in Caucasian populations [25,32,33] and ethnic groups of Turkish descent [26] . Although the frequency of different alleles in our control group correlated closely with those reported by Martino et al, [33] the overall distribution varied considerably across all included studies (Table 4).…”

“…The [31] 2014 Breast 115 136 15 266 66 153 5 224 Yes Luo Wang [29] 2006 GBM 133 132 34 299 106 98 20 224 Yes Yan Wang [28] 2008 Breast 860 141 5 1,006 984 107 4 1095 Yes Yang Zhang [22] 2011 NPC 725 71 2 798 891 121 7 1019 Yes Martino [33] 2016 Renal cell 116 106 20 242 148 201 71 420 Yes Wysoczanska [34] 2015 Lymphoma 28 37 10 75 53 54 19 126 No Zagouri [35] 2012 Breast 50 36 27 113 63 29 32 124 No Jin [16] 2011 Lung 820 110 7 937 840 101 2 943 No Andersson [32] 2009 Glioma 282 277 89 648 650 560 149 1359 Yes Carpentier [36] 2007 frequencies of different alleles of MNS16A observed for cases in our population correlated most closely with studies conducted on different cancers in Caucasian populations [25,32,33] and ethnic groups of Turkish descent. [26] Although the frequency of different alleles in our control group correlated closely with those reported by Martino et al, [33] the overall distribution varied considerably across all included studies (Table 4). [8,16,21,22,26,28,29,[31][32][33][34][35][36] This shows considerable variation in MNS16A alleles among different ethnic populations and makes it an interesting genetic polymorphism to be investigated as a risk factor for different cancers.…”

“…[9] Another study on MNS16A polymorphisms in prostate cancer cases and controls with benign prostatic hyperplasia showed no significant association with any variant form. [25] In a study on bladder cancer, SongulDiler et al [26] found comparable distributions of MNS16A VNTR S/L alleles and SS/ LL genotypes among bladder cancer cases and controls with no significant differences. Nonetheless, one common finding in our study and their study was a similar frequency of MNS16A SS genotype, 9.2% versus 10%, respectively.…”

“…[8] In addition, two other rare alleles, VNTR-272 and VNTR-333, were also found in cancer cell lines. Classification of VNTR-243 and VNTR-272 as short (S) alleles, and VNTR-302 and VNTR-333 as long (L) alleles, was introduced for the purposes of statistical analysis by Wang et al [21] The MNS16A variable number tandem repeat (VNTR) functional polymorphism has been investigated in various studies including nasopharyngeal carcinoma, [22] colorectal cancer, [8,23] lung cancer, [21,24] prostate cancer, [23,25] bladder cancer, [26] and in the normal human life span. [27] In this study, we aimed to determine whether the MNS16A VNTR polymorphism of the hTERT gene was associated with bladder cancer risk in a Kashmiri population.…”