The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma

Davidson, Ben; Konstantinovsky, Sophya; Kleinberg, Lilach; Nguyen, Minh‐Thanh; Bassarova, Assia; Kvalheim, Gunnar; Nesland, Jahn M.; Reich, Reuven

doi:10.1016/j.ygyno.2006.01.034

Cited by 74 publications

(62 citation statements)

References 30 publications

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“…p-ERK was detected in 73% of the tumor specimens, consistent with data reporting significant p-ERK expression in 69 to 96% of breast tumors (11,31,32). A low expression rate (35%) was only reported in one cohort (33).…”

Section: Discussionsupporting

confidence: 88%

“…In breast cancer, P38 MAPK expression has previously been correlated with invasiveness and poor prognosis (8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…In effusion specimens, p38 activation was reported to be inversely associated with the intensity of HER2 membrane expression (11).…”

Section: Discussionmentioning

confidence: 99%

“…Expression of phosphorylated-P38 MAPK (p-P38MAPK) has been reported in ~20% of primary breast carcinomas (9). P38 MAPK overexpression has been correlated with HER2 amplification and tamoxifen resistance (10) and has been proposed as a potential prognostic marker in breast cancer (11). Specifically, phosphorylation of P38 MAPK was found to be a negative prognostic indicator in HER2-negative, lymph node-positive breast cancers (9).…”

Section: Introductionmentioning

confidence: 99%

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Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins

Merlin¹,

Harlé²,

Lion³

et al. 2013

Oncology Reports

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Abstract. MAP kinase signaling proteins have major implications in the molecular oncogenesis of breast cancers and have been extensively investigated as putative targets for therapy. This study reports the investigation of the expression of P38 MAPK and its phosphorylated form (p-P38 MAPK) in clinical specimens of invasive breast carcinomas and their correlation with estrogen receptor (ER) and HER2 expression, as well as MAPK and PI3 kinase-AKT pathway signaling phosphorylated proteins. Expression levels of P38 MAPK and p-P38 MAPK as well as p-AKT, p-GSK3β, p-S6 kinase, p-MEK1 and p-ERK1/2 were quantitatively assessed using multiplex bead immunoassay in frozen specimens from 45 invasive ductal breast cancers. Twenty-nine specimens were ER + , 15 were HER2 + and 10 were triple-negative breast cancers (TNBCs). P38 MAPK was found to be expressed in all tumor specimens and was significantly (P= 0.002) overexpressed in ER + tumors. P38 MAPK expression was lower in TNBCs than in all of the other tumors.

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Section: Discussionsupporting

confidence: 88%

“…In breast cancer, P38 MAPK expression has previously been correlated with invasiveness and poor prognosis (8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

“…In effusion specimens, p38 activation was reported to be inversely associated with the intensity of HER2 membrane expression (11).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins

Merlin¹,

Harlé²,

Lion³

et al. 2013

Oncology Reports

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“…Jian-Hong Yang 1 , Jia Hu 1 , Li Wan 2 *, Li-Juan Chen 1 * and breast carcinoma (Davidson et al, 2006). Recent studies have shown the activation of MAPK signaling pathways including extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinases (JNK), and p38 MAPK (p38) in tumorigenesis, metastasis, and angiogenesis of multiple human malignancies (Huang et al, 2008).…”

Section: Barbigerone Inhibits Tumor Angiogenesis Growth and Metastasmentioning

confidence: 99%

Barbigerone Inhibits Tumor Angiogenesis, Growth and Metastasis in Melanoma

Yang¹,

Hu²,

Wan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Netrin‐4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors

Yuan

Leszczynska

Konstantinovsky

et al. 2010

Diagnostic Cytopathology

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We recently identified overexpression of the NTN4 gene in breast carcinoma effusions compared to primary carcinomas using gene-expression arrays. The objective of this study was to validate this finding at protein level and analyze the clinical role of Netrin-4 in breast carcinoma effusions. We additionally studied Netrin-4 expression and its clinical relevance in Müllerian (ovarian, peritoneal, and tubal) carcinoma effusions. Sections from 82 breast carcinomas (53 effusions and 29 solid tumors) and 57 Müllerian carcinoma effusions were stained for Netrin-4 using immunohistochemistry. Immunoreactivity was scored in carcinoma cells and analyzed for association with clinicopathologic parameters, including survival. In breast carcinoma, expression of Netrin-4 was detected in carcinoma cells in 30/53 (57%) effusions compared to 3/29 (10%) solid tumors (P < 0.001). Netrin-4 was further expressed in 31/57 (54%) Müllerian carcinoma effusions. No association was found between Netrin-4 expression in breast or Müllerian carcinoma effusions and clinicopathologic parameters, including survival. Our data provide validation on protein level of upregulated Netrin-4 expression in breast carcinoma effusions. The frequent expression of Netrin-4 in Müllerian carcinoma effusions suggests a biological role for this molecule in metastases from gynecological malignancies. Netrin-4 expression in effusions does not appear to be a predictor of disease outcome.

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The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma

Cited by 74 publications

References 30 publications

Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins

Expression and activation of P38 MAP kinase in invasive ductal breast cancers: Correlation with expression of the estrogen receptor, HER2 and downstream signaling phosphorylated proteins

Barbigerone Inhibits Tumor Angiogenesis, Growth and Metastasis in Melanoma

Netrin‐4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors

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