The mitochondrial challenge: Disorders and prevention strategies

Korchivaya, Elena; Silaeva, Yulia Yu.; Мазунин, И. О.; Volodyaev, I.V.

doi:10.1016/j.biosystems.2022.104819

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…The role of mitochondrial dysfunction in the comorbidity of COVID-19 and CVDs may be very significant. There have been reports of the involvement of mitochondria in the activation and regulation of the innate immune response, as well as in the intensification of inflammation and transition to its chronic form (including in COVID-19) [31]. But the mitochondrial phospholipid cardiolipin is a component of atheromas and a target of an autoimmune response in a number of diseases with impaired hemostasis.…”

Section: Respiratory Failure and Mixed Hypoxiamentioning

confidence: 99%

Aterosclerosis, Cardiovascular Disorders And Covid-19: Comorbid Pathogenesis

Makarova¹,

Ryabkova²,

Салухов³

et al. 2022

Preprint

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The article describes how atherosclerosis and coronavirus disease 19 (COVID-19) may affect each other. The features of this comorbid pathogenesis at various levels (vascular, cellular and molecular) are considered. A bidirectional influence of these conditions is described: the presence of cardiovascular diseases affects different individual susceptibility to viral infection. In turn, SARS-CoV-2 can have a negative effect on the endothelium and cardiomyocytes, causing blood clotting, secretion of pro-inflammatory cytokines, and thus exacerbating the development of atherosclerosis. In addition to the established entry into cells via ACE2 принимая во внимание его влияние на, other mechanisms of SARS-CoV-2 entry are currently under investigation, for example, through CD147. Pathogenesis of comorbidity can be determined by the influence of the virus on various links which are meaningful for atherogenesis: generation of oxidized forms of LDL, launch of a cytokine storm, damage to the endothelial glycocalyx, and mitochondrial injury. The transformation of a stable plaque into an unstable one plays an important role in the pathogenesis of atherosclerosis complications and can be triggered by COVID-19. The impact of SARS-CoV-2 on large vessels such as aorta is more complex than previously thought considering its impact on vasa vasorum. Current information on the mutual influence of the medicines used in the treatment of atherosclerosis and acute COVID-19 is briefly summarized

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Section: Respiratory Failure and Mixed Hypoxiamentioning

confidence: 99%

Aterosclerosis, Cardiovascular Disorders And Covid-19: Comorbid Pathogenesis

Makarova¹,

Ryabkova²,

Салухов³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Atherosclerosis, Cardiovascular Disorders and COVID-19: Comorbid Pathogenesis

et al. 2023

View full text Add to dashboard Cite

The article describes how atherosclerosis and coronavirus disease 19 (COVID-19) may affect each other. The features of this comorbid pathogenesis at various levels (vascular, cellular and molecular) are considered. A bidirectional influence of these conditions is described: the presence of cardiovascular diseases affects different individuals’ susceptibility to viral infection. In turn, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have a negative effect on the endothelium and cardiomyocytes, causing blood clotting, secretion of pro-inflammatory cytokines, and thus exacerbating the development of atherosclerosis. In addition to the established entry into cells via angiotensin-converting enzyme 2 (ACE2), other mechanisms of SARS-CoV-2 entry are currently under investigation, for example, through CD147. Pathogenesis of comorbidity can be determined by the influence of the virus on various links which are meaningful for atherogenesis: generation of oxidized forms of low-density lipoproteins (LDL), launch of a cytokine storm, damage to the endothelial glycocalyx, and mitochondrial injury. The transformation of a stable plaque into an unstable one plays an important role in the pathogenesis of atherosclerosis complications and can be triggered by COVID-19. The impact of SARS-CoV-2 on large vessels such as the aorta is more complex than previously thought considering its impact on vasa vasorum. Current information on the mutual influence of the medicines used in the treatment of atherosclerosis and acute COVID-19 is briefly summarized.

show abstract

The mitochondrial challenge: Disorders and prevention strategies

Cited by 2 publications

References 49 publications

Aterosclerosis, Cardiovascular Disorders And Covid-19: Comorbid Pathogenesis

Aterosclerosis, Cardiovascular Disorders And Covid-19: Comorbid Pathogenesis

Atherosclerosis, Cardiovascular Disorders and COVID-19: Comorbid Pathogenesis

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