Abstract:22Mitochondrial oxidative metabolism is central to glucose-stimulated insulin secretion (GSIS). 23 Whether Ca 2+ uptake into pancreatic β-cell mitochondria potentiates or antagonises this process 24 is still a matter of debate. Although the mitochondrial importer (MCU) complex is thought to 25 represent the main route for Ca 2+ transport across the inner mitochondrial membrane, its role 26 in β-cells has not previously been examined in vivo. Here, we inactivated the pore-forming 27 subunit MCUa (MCU) … Show more
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