The missing pieces in the jigsaw and need for cohesive research amidst coronavirus infectious disease 2019 global response

Gupta, Navneet; Singhai, Monil; Garg, Shubha; Shah, Dhara; Sood, Vishesh; Singh, Sujeet Kumar

doi:10.1016/j.mjafi.2020.04.001

Cited by 9 publications

(8 citation statements)

References 5 publications

(3 reference statements)

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“…This could be achieved through knowledge, attitude, and practice (KAP) studies [ 14 , 15 ]. The information generated from such studies, in addition to comprehensive reviews and recommendations, could help in the fight against COVID-19 and similar future threats [ 14 – 17 ] by improving the awareness level of the citizens and encourage positive attitudes which are necessary to beat the pandemic. These are necessary for both countries especially with the onset of community spread of the disease.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

et al. 2020

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The current Coronavirus (COVID-19) pandemic has impacted and changed lives on a global scale since its emergence and spread from China in late 2019. It has caused millions of infections, and thousands of deaths worldwide. However, the control of this pandemic still remains unachievable in many African countries including Egypt and Nigeria, despite the application of some strict preventive and control measures. Therefore, this study assessed the knowledge, attitude, and perceptions of Egyptians and Nigerians towards the COVID-19 pandemic. This study was designed as a cross-sectional community-based questionnaire survey in both countries. Participants' demography, knowledge, attitude, and perceptions towards the COVID-19 outbreak were obtained using a convenience sampling technique. Data collected were subjected to descriptive statistics and logistic regression analysis. A total of 1437 respondents were included in this preliminary report. The mean knowledge score was 14.7±2.3. The majority of the respondents (61.6%) had a satisfactory knowledge of the disease. Age (18-39 years), education (College/bachelors), and background of respondents were factors influencing knowledge levels. The attitude of most respondents (68.9%) towards instituted preventive measures was satisfactory with an average attitude score of 6.9 ± 1.2. The majority of the respondents (96%) practiced self-isolation and socialdistancing but only 36% follow all health recommendations. The perception of most respondents (62.1%) on the global efforts at controlling the virus and preventing further spread was satisfactory with an average score of 10.9 ± 2.7. Only 22% of the respondents were satisfied with their country's handling of the pandemic. An apprehensive understanding of the current status in Africa through studies like KAP is crucial to avoid Africa being the next epicenter of the pandemic. For the populace to follow standard infection prevention and control

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Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

et al. 2020

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“…This could be achieved through knowledge, attitude, and practice (KAP) studies. The information generated from such studies, in addition to comprehensive reviews and recommendations, could help in the fight against COVID-19 and similar future threats (13; 14).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

Elnadi

Odetokun

Bolarinwa

et al. 2020

Preprint

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The current Coronavirus (COVID-19) pandemic has changed and impacted lives on a global scale since its emergence and spread from China in late 2019. It has caused millions of infections, and thousands of deaths worldwide. However, the control of this pandemic still remains unachievable in many African countries including Egypt and Nigeria, despite the application of some strict preventive and control measures. Therefore, this study assessed the knowledge, attitude and perceptions of Egyptians and Nigerians towards COVID-19 pandemic. A total of 1437 respondents were included in this preliminary cross-sectional survey. The mean knowledge score was 14.7 plusmn 2.3. The majority of the respondents (61.6%) had a satisfactory knowledge of the disease. Age (18-39 years), education (College/bachelors) and background of respondents were factors influencing knowledge levels. The attitude of most respondents (68.9%) towards the preventive measures was satisfactory with an average attitude score of 6.9 plusmn 1.2. The majority of the respondents (96%) practiced self-isolation and social-distancing but only 36% follow all health recommendations. The perception of most respondents (62.1%) on the global efforts at controlling the virus and preventing further spread was satisfactory with an average score of 10.9 plusmn 2.7. A satisfactory knowledge of COVID-19 was significantly associated with good attitude and perceptions (p < 0.001) of respondents. Only 22% of the respondents were satisfied with their country prime s handling of the pandemic. It is imperative that to avoid Africa being the next epicenter of the pandemic. Governments need to strengthen health systems, improve their surveillance activities in detecting cases, and effectively apply standard infection prevention and control measures.

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“…COVID-19 (Coronavirus Disease 2019) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), a member of Betacoronaviruses (β-CoV) genera of coronaviruses group of related viruses. In addition to Covid-19, betacoronaviruses were also responsible for 2002–2004 outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV); and 2012 outbreak of Middle East Respiratory Syndrome (MERS-dCoV), first identified in China and Saudi Arabia respectively [ [1] , [2] , [3] ].…”

Section: Introductionmentioning

confidence: 99%

Utilizing drug repurposing against COVID-19 – Efficacy, limitations, and challenges

2020

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The recent outbreak of Coronavirus disease (COVID-19), first in Eastern Asia and then essentially across the world has been declared a pandemic by the WHO. COVID-19 is caused by a novel virus SARS-CoV2 (2019-nCoV), against which there is currently no vaccine available; and current antiviral therapies have failed, causing a very high mortality rate. Drug repurposing i.e. utilizing an approved drug for different indication, offers a time- and cost-efficient alternative for making new therapies available to patients. Although there are several reports presenting novel approaches to treat COVID-19, still an attentive review of previous scientific literature is essential to overcome their failure to exhibit efficacy. There is an urgent need to provide a comprehensive outlook toward utilizing drug repurposing as a tool for discovery of new therapies against COVID-19. In this article, we aim to provide a to-the-point review of current literature regarding efficacy of repurposed drugs against COVID-19 and other respiratory infections caused by coronaviruses. We have briefly discussed COVID-19 epidemiology, and then have discussed drug repurposing approaches and examples, specific to respiratory viruses. Limitations of utilization of repurposed drug molecules such as dosage regimen and associated challenges such as localized delivery in respiratory tract have also been discussed in detail.

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The missing pieces in the jigsaw and need for cohesive research amidst coronavirus infectious disease 2019 global response

Cited by 9 publications

References 5 publications

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

Knowledge, attitude, and perceptions towards the 2019 Coronavirus Pandemic: A bi-national survey in Africa

Utilizing drug repurposing against COVID-19 – Efficacy, limitations, and challenges

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