The missing link in rhesus monkey amniotic fluid volume regulation: Intramembranous absorption

Gilbert, William M.; Eby-Wilkens, Elaine; Tarantal, Alice F.

doi:10.1016/s0029-7844(96)00509-1

Cited by 94 publications

(92 citation statements)

References 14 publications

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“…Alternatively, contrast medium from the maternal circulation may equilibrate directly into the amniotic fluid by passive intramembranous diffusion and this fluid is then also swallowed by the fetus [9].…”

Section: Discussionmentioning

confidence: 99%

Transplacental passage of a nonionic contrast agent

et al. 2005

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We report the presence of iopromide in the bowel and urine of a preterm infant, born 10 days after intravenous administration of the nonionic monomer to his mother. Excessive urinary iodine excretion and borderline hyperthyrotropinaemia were observed in the infant. Moreover, crossing of the fetal blood-brain barrier was demonstrated by detection of the angiographic material in CSF and thus direct fetal neurotoxic effects cannot be excluded. Conclusion: These widely used contrast media may cross the placenta and accumulate in various fetal tissues in significant amounts causing possible neonatal toxicity. Therefore the perinatal safety of these diagnostic agents should at least be questioned.

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Section: Discussionmentioning

confidence: 99%

Transplacental passage of a nonionic contrast agent

et al. 2005

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“…Following keratinization of the fetal skin (slightly after mid-gestation), amniotic fluid is considered to be a product mainly of fetal urination which approximates 30% of fetal body weight daily, and at term ranges between 600 and 1200 mL/day [1][2][3] .…”

Section: Physiological Dynamics Of Amniotic Fluidmentioning

confidence: 99%

“…Similarly, in animal studies in which fetal swallowing was prevented, fetal urine output remained normal and amniotic fluid volume was not different from that of the controls after 2 -3 weeks 2 . Gilbert and Brace 3 demonstrated that absorption through the intramembranous pathway was increased with ligation of the fetal esophagus. Regarding amniotic fluid turnover, late in gestation when amniotic fluid volume averages 700 -800 mL, 1000 mL fluid flows into and out of the amniotic compartment daily 1,2 .…”

Section: Physiological Dynamics Of Amniotic Fluidmentioning

confidence: 99%

Oligohydramnios: use and misuse in clinical management

Sherer

Langer

2001

Ultrasound in Obstet & Gyne

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“…By term, the amount of amniotic fluid swallowed by the fetus is between 500 and 1,000 mL/day. 29 The second route for reabsorption into the fetal circulation is the intermembranous pathway. This pathway involves the absorption of amniotic fluid across the amnion and into the fetal vasculature driven by osmotic differences.…”

mentioning

confidence: 99%

“…This pathway involves the absorption of amniotic fluid across the amnion and into the fetal vasculature driven by osmotic differences. 29 In the last two trimesters of pregnancy, fetal exposure to ethanol is further prolonged. This is the result of the recurrent cycle of fetal swallowing of the amniotic fluid containing ethanol, and elimination of urine containing alcohol back into the amniotic fluid.…”

mentioning

confidence: 99%

Fetal alcohol exposure and development of the integument

Longhurst¹,

Ernst²,

Burd³

2016

RRN

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Background:The physiology of fetal alcohol exposure changes across gestation. Early in pregnancy placental, fetal, and amniotic fluid concentrations of alcohol exposure are equivalent. Beginning in mid-pregnancy, the maturing fetal epidermis adds keratins which decrease permeability resulting in development of a barrier between fetal circulation and the amniotic fluid. Barrier function development is essential for viability in late pregnancy and in the extra-uterine environment. In this paper we provide a selected review of the effects of barrier function on fetal alcohol exposure. Methods: We utilized a search of PubMed and Google for all years in all languages for MeSH on Demand terms: alcohol drinking, amnion, amniotic fluid, epidermis, ethanol, female, fetal development, fetus, humans, keratins, permeability, and pregnancy. We also reviewed the reference lists of relevant papers and hand-searched reference lists of textbooks for additional references. Results: By 30 gestational weeks, development of barrier function alters the pathophysiology of ethanol dispersion between the fetus and amniotic fluid. Firstly, increases in the effectiveness of barrier function decreases the rate of diffusion of alcohol from fetal circulation across fetal skin into the amniotic fluid. This reduces the volume of alcohol entering the amniotic fluid. Secondly, barrier function increases the duration of fetal exposure by decreasing the rate of alcohol diffusion from amniotic fluid back into fetal circulation. Ethanol is then transported into maternal circulation for metabolism or elimination. Conclusion: In late pregnancy, barrier function modifies alcohol diffusion rates across the epidermis back into fetal circulation. This increases the duration of exposure from each episode of drinking. This information may be useful for clinicians who care for women with alcohol use disorders during pregnancy, and may also be useful in explaining the rationale for avoiding alcohol use throughout pregnancy, including late pregnancy.

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The missing link in rhesus monkey amniotic fluid volume regulation: Intramembranous absorption

Abstract: These results suggest that intramembranous absorption occurs and may play an important role in rhesus AF volume regulation and composition. Furthermore, this animal model, which closely resembles the human, may provide valuable insight into abnormalities of human AF volume regulation.

Cited by 94 publications

References 14 publications

Transplacental passage of a nonionic contrast agent

Transplacental passage of a nonionic contrast agent

Oligohydramnios: use and misuse in clinical management

Fetal alcohol exposure and development of the integument

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