The mismatch negativity (MMN) response to complex tones and spoken words in individuals with aphasia

Pettigrew, Catharine M.; Murdoch, Bruce E.; Kei, Joseph; Ponton, Curtis W.; Alku, Paavo; Chenery, Helen J.

doi:10.1080/02687030444000642

Cited by 27 publications

(16 citation statements)

References 57 publications

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“…Auther et al (2000) found that the presence of an MMN to speech-sound changes was an indicator of better speech comprehension compared to patients with an absent MMN to the same speech sounds. Pettigrew et al (2005) also reported a strong correlation between auditory comprehension in patients with aphasia and MMN amplitudes to complex-tone duration decrement and to syllable changes. Wertz et al (1998) observed that a clear MMN to a speech-sound change was present in only 54 % of aphasic subjects.…”

Section: What Is the Mmn?mentioning

confidence: 86%

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

et al. 2014

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Cognition is often affected in a variety of neuropsychiatric, neurological, and neurodevelopmental disorders. The neural discriminative response, reflected in mismatch negativity (MMN) and its magnetoencephalographic equivalent (MMNm), has been used as a tool to study a variety of disorders involving auditory cognition. MMN/MMNm is an involuntary brain response to auditory change or, more generally, to pattern regularity violation. For a number of disorders, MMN/MMNm amplitude to sound deviance has been shown to be attenuated or the peak-latency of the component prolonged compared to controls. This general finding suggests that while not serving as a specific marker to any particular disorder, MMN may be useful for understanding factors of cognition in various disorders, and has potential to serve as an indicator of risk. This review presents a brief history of the MMN, followed by a description of how MMN has been used to index auditory processing capability in a range of neuropsychiatric, neurological, and neurodevelopmental disorders. Finally, we suggest future directions for research to further enhance our understanding of the neural substrate of deviance detection that could lead to improvements in the use of MMN as a clinical tool.

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Section: What Is the Mmn?mentioning

confidence: 86%

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

et al. 2014

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“…Large differences in auditory features of stimuli have been shown to elicit MMNs with large amplitudes and short latencies, whereas smaller differences induce decreased amplitudes and increased latencies (e.g., Sams, Paavilianen, Alho, & N€ a€ at€ anen, 1985). MMN has been used to measure auditory discrimination abilities in different patient groups with languagerelated deficits including specific language impairment, dyslexia, and aphasia, and diminished MMN has been reported in these clinical groups for differences in various auditory features including frequency, rhythm, duration, and consonant and speech-sound differences (Baldeweg, Richardson, Watkins, Foale, & Gruzelier, 1999;Ilvonen et al, 2001;Kraus et al, 1996;Pettigrew et al, 2005;Schulte-K€ orne, Deimel, Bartling, & Remschmidt, 1998). MMN has furthermore been used to measure changes in auditory discrimination accuracy following training, learning, or during recovery from brain damage, and thus has been used to study brain plasticity in musicians, language learners, or neurological patients (e.g., Ilvonen et al, 2003;Tervaniemi, Rytk€ onen, Schr€ oger, Ilmoniemi, & N€ a€ at€ anen, 2001;Yue, Bastiaanse, & Alter, 2014).…”

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confidence: 99%

A systematic review of the mismatch negativity as an index for auditory sensory memory: From basic research to clinical and developmental perspectives

et al. 2015

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Auditory sensory memory is an important ability for successful language acquisition and processing. The mismatch negativity (MMN) in response to auditory stimuli has been proposed as an objective tool to measure the existence of auditory sensory memory traces. By increasing interstimulus intervals, attenuation of MMN peak amplitude and increased MMN peak latency have been suggested to reflect duration and decay of sensory memory traces. The aim of the present study is to conduct a systematic review of studies investigating sensory memory duration with MMN. Searches of electronic databases yielded 743 articles. Of these, 37 studies met final eligibility criteria. Results point to maturational changes in the time span of auditory sensory memory from birth on with a peak in young adulthood, as well as to a decrease of sensory memory duration in healthy aging. Furthermore, this review suggests that sensory memory decline is related to diverse neurological, psychiatric, and pediatric diseases, including Alzheimer's disease, alcohol abuse, schizophrenia, and language disorders. This review underlines that the MMN provides a unique window to the cognitive processes of auditory sensory memory. However, further studies combining electrophysiological and behavioral data, and further studies in clinical populations are needed, also on individual levels, to validate the MMN as a clinical tool for the assessment of sensory memory duration.

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“…This might be a limitation if a clinician wants to assess neuronal processes or time-locked brain activities which require high temporal resolution, such as perception, attention, or echoic memory traces [10][11][12]. Electrophysiological methods, such as event-related potentials (ERPs), are a non-invasive technique that can be used to investigate temporal aspects of auditory discrimination using verbal and non-verbal stimuli, especially in cases having abnormal language function [13,14]. Although ERPs have been used to investigate language processes since the 1980s [14][15][16][17], its clinical application in aphasic patients has been minimal.…”

Section: Introductionmentioning

confidence: 99%

“…Electrophysiological methods, such as event-related potentials (ERPs), are a non-invasive technique that can be used to investigate temporal aspects of auditory discrimination using verbal and non-verbal stimuli, especially in cases having abnormal language function [13,14]. Although ERPs have been used to investigate language processes since the 1980s [14][15][16][17], its clinical application in aphasic patients has been minimal.…”

Section: Introductionmentioning

confidence: 99%

“…Using auditory oddball paradigms it has been shown that the MMN (elicited by frequency and duration changes) is attenuated in amplitude in patients with a left-hemispheric stroke [14,[40][41][42]. Furthermore, Ilvonen and colleagues [43] followed the recovery of eight left-hemisphere stroke patients: in the first 10 days the MMNs were quite small in amplitude for both duration and frequency changes; however, they became progressively larger, reaching normal amplitudes between 3 to 6 months after stroke, and with an improvement in speech-comprehension during the follow-up period.…”

Section: Introductionmentioning

confidence: 99%

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Mismatch Negativity and the N2b Component Elicited by Pure Tones and Speech Sounds in Anomic Aphasia: A Case Study

et al. 2015

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Background:The auditory processing impairments frequently observed in aphasia are being slowly clarified by using eventrelated potentials (ERPs), a method that allows brain processes to be observed at high temporal resolution. Mismatch negativity (MMN) and the N2b amplitude reflect aspects of echoic memory, attention, and phonological representation. This study evaluates the auditory processing of speech and pure tones in an anomic aphasia subject 6 years after a stroke, and investigates whether ERPs can detect possible neurophysiologic sequelae after recovery and rehabilitation. Material and methods:A recovered subject with anomic aphasia, 6 years post-stroke, was compared with 6 healthy controls. Event-related potentials (MMN, N1, N2b) were obtained during two auditory oddball paradigms, one using pure tones and the other consonant-vowel (CV) stimuli.Results: When compared to healthy subjects, the anomic aphasia subject had reduced MMN amplitude across the frontocentral electrode sites, particularly for speech stimuli. Average deviant waveform analysis revealed poor morphology of N2b to speech stimuli, which might relate to deficits in phonological representation. Conclusions:In the presented case the neurophysiologic brain activity for processing of phonologic representations had not fully recovered 6 years post-stroke. MMN and N2b are highly sensitive ERPs for evaluating impairments in auditory processing and can be registered in the absence of attention and with no task requirements, features which makes it particularly suitable for investigating aphasic subjects.

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The mismatch negativity (MMN) response to complex tones and spoken words in individuals with aphasia

Cited by 27 publications

References 57 publications

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction

A systematic review of the mismatch negativity as an index for auditory sensory memory: From basic research to clinical and developmental perspectives

Mismatch Negativity and the N2b Component Elicited by Pure Tones and Speech Sounds in Anomic Aphasia: A Case Study

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