The Minipig in Biomedical Research

McAnulty, Peter A.; Dayan, Anthony D.; Ganderup, Niels-Christian; Hastings, Kenneth L.

doi:10.1201/b11356

Cited by 51 publications

(5 citation statements)

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“…Minipigs reach sexual maturity at an earlier age than larger domestic pigs. Minipigs are a genetically defined model; the majority of breeds have their entire population history documented, beginning at their early development up to present [2,3]. There are some breed-specific characteristics, such as cytochrome P450 enzyme levels and activities [4].…”

Section: Introductionmentioning

confidence: 99%

Minipigs as models in drug discovery

Singh

Thrall

Hauer‐Jensen

2016

Expert Opinion on Drug Discovery

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Section: Introductionmentioning

confidence: 99%

Minipigs as models in drug discovery

Singh

Thrall

Hauer‐Jensen

2016

Expert Opinion on Drug Discovery

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“…To obtain valuable information on pharmacological and toxicological effects of a drug candidate for subsequent clinical development in man, the commonly used species (mice, rats, rabbits, and dogs) may not always be appropriate. The minipig could be a good alternative as its anatomy and physiology are very similar to those of humans in many aspects (Jørgensen 1998;Bode et al 2010;McAnulty et al 2012). In regulatory toxicology studies, female Göttingen minipigs are typically 4-5 months of age at the start of experimental studies.…”

mentioning

confidence: 99%

Sexual Maturation in the Female Göttingen Minipig

Peter¹,

Rijk²,

Zeltner³

et al. 2016

Toxicol Pathol

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In the literature, experimental data on sexual maturation of female Gö ttingen minipigs are lacking. This may impede a reliable evaluation of reproductive functioning, particularly in the young (immature) sow used in toxicity studies. To find suitable method(s) to detect ovulation during in-life, a pilot study was performed with 3 adult sows (approximately 10-11 months), followed by a study with 14 immature females (approximately 3-4 months). From the tested parameters, progesterone analysis was the most reliable predictor. First progesterone peaks were observed in 13 sows at 3.7-4.2 or 5.5-6.5 months with a cycle length of 17-22 days. One sow did not show progesterone release until necropsy at 7 months of age. Histopathology of the reproductive organs confirmed sexual maturity for all sows, except the one without progesterone peak. In conclusion, the age range of sexual maturity of female Gö ttingen minipigs (3.7-6.5 months) is much wider than previously thought, and in-life progesterone analysis is a useful tool to determine sexual maturity of individual animals.

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“…The use of minipigs in biomedical research has been increasing over the past decades, 9 and understanding of swine physiology and pathophysiology, including cardiophysiology, is increasing as well. 10,11 For an example, a comparison of human and swine similarities and differences focusing on the cardiovascular system and related functions is displayed in Table 4.…”

Section: Discussionmentioning

confidence: 99%

Comparative cardiovascular physiology and pathology in selected lineages of minipigs

Stricker–Krongrad

Shoemake

Brocksmith

et al. 2017

Toxicology Research and Application

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The minipig has been increasingly recognized as a valid alternative to canines and nonhuman primates in regulatory toxicity. This article presents the results of cardiovascular assessments in the Yucatan, Hanford, Sinclair, and Göttingen minipigs conducted during nonclinical investigations and control toxicity testing. Cardiac electrophysiology was obtained using clinical electrocardiogram and surgical monitor units. Peripheral vessel diameter, velocity, and flow were obtained by Doppler ultrasonography, and cardiac vessel diameter was obtained postmortem. Anatomic parameters were obtained at necropsy. Histopathology assessments were conducted on heart, blood vessels, and kidneys. Collected data were compared to published cardiovascular measurements of adult humans to illustrate similarities and differences. Each lineage of minipigs was found to have specific anatomic and physiologic characteristics that may accurately reflect response of human cardiovascular systems in clinical investigations and toxicity testing. In conclusion, the interspecies similarities between the cardiovascular systems make these lineages of minipigs suitable as models for the human counterpart. In addition, these reported differences between lineages will aid investigators in selecting a relevant lineage of minipigs if specific cardiovascular parameters are required during drug safety evaluation.

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The Minipig in Biomedical Research

Cited by 51 publications

References 0 publications

Minipigs as models in drug discovery

Minipigs as models in drug discovery

Sexual Maturation in the Female Göttingen Minipig

Comparative cardiovascular physiology and pathology in selected lineages of minipigs

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