The Minimum Riboflavin Requirement of the Infant

Snyderman, Selma E.; Ketron, Katherine C.; Burch, Helen B.; Lowry, Oliver H.; Bessey, Otto A.; Guy, Loren P.; Holt, L. Emmett

doi:10.1093/jn/39.2.219

Cited by 24 publications

(2 citation statements)

References 5 publications

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“…The Health Council of the Netherlands () derived AI for infants up to 5 months at 0.4 mg/day on the basis of a daily human milk consumption of 0.8 L and a riboflavin concentration in milk of 0.53 mg/L (Fomon and McCormick, ). For children and adolescents, data to set ARs were considered too limited (Oldham, ; Snyderman and Ketron, ; Lo, ). Thus, an interpolation between the reference values of infants (under 5 months) and of adults was used to set AIs of children and adolescents, following the IOM () approach.…”

Section: Overview Of Dietary Reference Values and Recommendationsmentioning

confidence: 99%

Dietary Reference Values for riboflavin

Products¹,

Turck²,

Bresson³

et al. 2017

EFS2

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for riboflavin. The Panel considers that the inflection point in the urinary riboflavin excretion curve in relation to riboflavin intake reflects body saturation and can be used as a biomarker of adequate riboflavin status. The Panel also considers that erythrocyte glutathione reductase activation coefficient is a useful biomarker, but has limitations. For adults, the Panel considers that average requirements (ARs) and population reference intakes (PRIs) can be determined from the weighted mean of riboflavin intake associated with the inflection point in the urinary riboflavin excretion curve reported in four intervention studies. PRIs are derived for adults and children assuming a coefficient of variation of 10%, in the absence of information on the variability in the requirement and to account for the potential effect of physical activity and the methylenetetrahydrofolate reductase 677TT genotype. For adults, the AR and PRI are set at 1.3 and 1.6 mg/day. For infants aged 7-11 months, an adequate intake of 0.4 mg/day is set by upward extrapolation from the riboflavin intake of exclusively breastfed infants aged 0-6 months. For children, ARs are derived by downward extrapolation from the adult AR, applying allometric scaling and growth factors and considering differences in reference body weight. For children of both sexes aged 1-17 years, ARs range between 0.5 and 1.4 mg/day, and PRIs between 0.6 and 1.6 mg/day. For pregnant or lactating women, additional requirements are considered, to account for fetal uptake and riboflavin accretion in the placenta during pregnancy or the losses through breast milk, and PRIs of 1.9 and 2.0 mg/day, respectively, are derived.

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Section: Overview Of Dietary Reference Values and Recommendationsmentioning

confidence: 99%

Dietary Reference Values for riboflavin

Products¹,

Turck²,

Bresson³

et al. 2017

EFS2

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“…In the first study designed to determine the minimum riboflavin requirement of term infants, Snyderman et al (1949) conducted metabolic balances on three infants who were 14, 22, and 32 months of age, weighing 5.9, 8.6, and 9 kg respectively. Two of the infants were studied for 143 days.…”

Section: Review Of the Literaturementioning

confidence: 99%

Nutrient Requirements For Preterm Infant Formulas

Klein

2002

The Journal of Nutrition

327

231

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Achieving appropriate growth and nutrient accretion of preterm and low birth weight (LBW) infants is often difficult during hospitalization because of metabolic and gastrointestinal immaturity and other complicating medical conditions. Advances in the care of preterm-LBW infants, including improved nutrition, have reduced mortality rates for these infants from 9.6 to 6.2% from 1983 to 1997. The Food and Drug Administration (FDA) has responsibility for ensuring the safety and nutritional quality of infant formulas based on current scientific knowledge. Consequently, under FDA contract, an ad hoc Expert Panel was convened by the Life Sciences Research Office of the American Society for Nutritional Sciences to make recommendations for the nutrient content of formulas for preterm-LBW infants based on current scientific knowledge and expert opinion. Recommendations were developed from different criteria than that used for recommendations for term infant formula. To ensure nutrient adequacy, the Panel considered intrauterine accretion rate, organ development, factorial estimates of requirements, nutrient interactions and supplemental feeding studies. Consideration was also given to long-term developmental outcome. Some recommendations were based on current use in domestic preterm formula. Included were recommendations for nutrients not required in formula for term infants such as lactose and arginine. Recommendations, examples, and sample calculations were based on a 1000 g preterm infant consuming 120 kcal/kg and 150 mL/d of an 810 kcal/L formula. A summary of recommendations for energy and 45 nutrient components of enteral formulas for preterm-LBW infants are presented. Recommendations for five nutrient:nutrient ratios are also presented. In addition, critical areas for future research on the nutritional requirements specific for preterm-LBW infants are identified.

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Clinical Significance of Riboflavin Deficiency

Komindr

Nichoalds

1980

Nutritional Elements and Clinical Biochemistry

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The Minimum Riboflavin Requirement of the Infant

Cited by 24 publications

References 5 publications

Dietary Reference Values for riboflavin

Dietary Reference Values for riboflavin

Nutrient Requirements For Preterm Infant Formulas

Clinical Significance of Riboflavin Deficiency

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