The Minimum Alveolar Concentration of Nitrous Oxide in Man

Hornbein, Thomas F.; Eger, Edmond I.; Winter, P.; Smith, G.; Wetstone, Dana; Smith, Kent H.

doi:10.1213/00000539-198207000-00001

Cited by 171 publications

(56 citation statements)

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“…The most commonly used endpoint for inhalational anesthetics is the minimum alveolar concentration (MAC), which is the concentration required to prevent a purposeful response to a painful stimulus, such as a surgical incision. For the anesthetics we have used, these concentrations are (for humans) 0.75% for halothane (Steward et al, 1973), 71% for xenon (Cullen et al, 1969), 104% for nitrous oxide (Hornbein et al, 1982), and 9.2% for cyclopropane (Saidman et al, 1967). It should be noted, however, that these concentrations were determined at 37°C, and MAC values decrease with decreasing temperature.…”

Section: Methodsmentioning

confidence: 99%

Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Gruß

Bushell²,

Bright³

et al. 2004

Mol Pharmacol

286

192

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Nitrous oxide, xenon, and cyclopropane are anesthetic gases that have a distinct pharmacological profile. Whereas the molecular basis for their anesthetic actions remains unclear, they behave very differently to most other general anesthetics in that they have little or no effect on GABA A receptors, yet strongly inhibit the N-methyl-D-aspartate subtype of glutamate receptors. Here we show that certain members of the two-poredomain

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Section: Methodsmentioning

confidence: 99%

Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Gruß

Bushell²,

Bright³

et al. 2004

Mol Pharmacol

286

192

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“…The MAC of sevoflurane was taken as 1.71%; 5 of isoflurane as 1.15%; 6 and of N20 as 104%. 7 Intermittent doses of vecuronium iv were administered to maintain muscle paralysis. After induction of anaesthesia, a subclavian central venous pressure (CVP) catheter was inserted.…”

Section: Methodsmentioning

confidence: 99%

Changes in the cerebral arteriovenous oxygen content difference by surgical incision are similar during sevoflurane and isoflurane anaesthesia

et al. 1996

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“…12 Nitrous oxide also causes PONV due to changes in middle ear pressure 13 or bowel distention due to diffusion into closed cavities. 14 In an animal model, nitrous oxide activated the medullary dopaminergic system.…”

Section: Nitrous Oxidementioning

confidence: 99%

Comparison of Prophylactic Antiemetic Efficacy of Haloperidol and Granisetron for the Prevention of Postoperative Nausea and Vomiting Followed by Laparoscopic Surgeries

B¹,

Bhat²,

Narendra³

2016

jemds

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BACKGROUNDPostoperative Nausea and Vomiting (PONV) continues to be a highly undesirable outcome of anaesthesia and surgery. For example, in the ambulatory care surgery setting PONV is among the most common complications with a frequency ranging from 30% to 50%. 1 In addition, significant or uncontrolled PONV in the ambulatory surgery Post Anaesthesia Care Unit (PACU) can lead to unanticipated hospital admission. Although routine antiemetic prophylaxis is clearly unjustified, patients at high risk for postoperative emesis should receive special considerations with respect to the prophylactic use of antiemetic drugs. 2 Retching or vomiting following surgery can put tension on suture lines, cause haematomas beneath surgical flaps and place the patient at risk for pulmonary aspiration of vomit if airway reflexes are depressed from the lingering effects of anaesthetic and analgesic drug.

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The Minimum Alveolar Concentration of Nitrous Oxide in Man

Cited by 171 publications

References 0 publications

Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Changes in the cerebral arteriovenous oxygen content difference by surgical incision are similar during sevoflurane and isoflurane anaesthesia

Comparison of Prophylactic Antiemetic Efficacy of Haloperidol and Granisetron for the Prevention of Postoperative Nausea and Vomiting Followed by Laparoscopic Surgeries

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The Minimum Alveolar Concentration of Nitrous Oxide in Man

Cited by 171 publications

References 0 publications

Two-Pore-Domain K+ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Two-Pore-Domain K+ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Changes in the cerebral arteriovenous oxygen content difference by surgical incision are similar during sevoflurane and isoflurane anaesthesia

Comparison of Prophylactic Antiemetic Efficacy of Haloperidol and Granisetron for the Prevention of Postoperative Nausea and Vomiting Followed by Laparoscopic Surgeries

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Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane

Two-Pore-Domain K⁺ Channels Are a Novel Target for the Anesthetic Gases Xenon, Nitrous Oxide, and Cyclopropane