The Mini-Mental State Examination: Czech Norms and Cutoffs for Mild Dementia and Mild Cognitive Impairment due to Alzheimer's Disease

Bartoš, Aleš; Raisova, Miloslava

doi:10.1159/000446426

Cited by 35 publications

(33 citation statements)

References 25 publications

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“…Normative data also provide independent verification of cutoff scores derived from a comparison between people with and without cognitive deficits. In the current study we replicated the approach applied for the MMSE [31]. Scores of the MoCA may be also influenced by age or education [8, 10-13, 16, 32-33].…”

Section: Introductionmentioning

confidence: 64%

“…The patients had an established diagnosis of AD from an experienced neurologist (A.B.). The diagnosis was based on: objective evidence of a progressive decline in cognition; neurological, neuropsychological, and functional assessments; a blood work-up; hippocampal atrophy seen on brain magnetic resonance imaging (or computer tomography in case of contraindications); temporo-parietal hypoperfusion seen using single photon emission computed tomography; or increased total or phosphorylated τ protein and/or decreased amyloid-β concentrations in cerebrospinal fluid using cutoffs established in our previous studies [30, 31, 36-40]. The MoCA results were not involved in diagnostic considerations since the MoCA was administered after the diagnosis had already been established.…”

Section: Participants and Methodsmentioning

confidence: 99%

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Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Bartoš

Fayette

2018

Dement Geriatr Cogn Disord

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Background: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population. Method: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults. Results: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 ± 4 vs. 26 ± 3 points; p = 0.03). Under the recommended cutoff score of ≤25, the MoCA-CZ demonstrated an excellent sensitivity of 94% but a low specificity of 62%. When the score was reduced to ≤24, the MoCA-CZ showed an optimal sensitivity of 87% for AD-MCI and a specificity of 72%. Normal elderly persons should recall at least 2 words after delay (sensitivity 80%, specificity 74%). Several cutoff points were derived from normative data stratified by age and education. Conclusions: The cutoff for AD-MCI and stratified norms are available for the MoCA total score and delayed recall of the Czech version. The cut-off scores of the MoCA-CZ, sensitivity, and specificity are lower than in the original study.

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Section: Introductionmentioning

confidence: 64%

Section: Participants and Methodsmentioning

confidence: 99%

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Bartoš

Fayette

2018

Dement Geriatr Cogn Disord

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“…Cognitive functions were evaluated by means of MMSE [10, 11], CDT (Clock Drawing Task) [12]. An MMSE score of 30–28 points represented a normal finding, 27–25 points – mild cognitive impairment (MCI), 24–19 points – mild dementia, 18–13 points – moderate dementia, and 12–0 points – severe dementia.…”

Section: Methodsmentioning

confidence: 99%

Prevalence, Recognition, and Treatment of Dementia in Assisted Living Facilities

Šutovský

Kŕaĺová

Šiarnik

et al. 2018

Dement Geriatr Cogn Disord

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Background/Aims: Dementia and psychiatric disorders are common in assisted living facilities (ALFs) and have suboptimal rates of recognition and treatment. Therefore, we aimed to obtain a direct estimate of the prevalence of cognitive impairment and especially dementia among residents of ALFs in western Slovakia and their rates of primary recognition and adequate treatment. Methods: We conducted two cross-sectional studies. Ten ALFs within the city of Bratislava were chosen for the study in 2004, and again in 2011. A total of 866 residents in ALFs were examined in 2004, and 821 residents in ALFs were examined in 2011. The rate and characterization of dementia, its primary recognition and adequate treatment were investigated in both cross-sectional studies. Results: In 2004, 57% of the participants had dementia. Only 7.2% of the participants with probable Alzheimer disease were treated with acetylcholinesterase inhibitors. In 2011, we observed a significant improvement in primary diagnostics and therapy. 66.9% of the cases of dementia were adequately evaluated, and 52.1% were adequately treated. Conclusion: Cognitive deficit and dementia are significantly underdiagnosed and undertreated in assisted living settings. In the second cross-sectional study we detected significant but not complete improvement in the primary recognition and adequate therapy of dementia.

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“…headache, Bell's palsy). They had normal MMSE and ACE-R-CZ scores and a normal CSF triplet (t-tau, p-tau, Abeta proteins) based on cut-offs established in our and other previous studies 24,28,32,33 . These patients underwent a lumbar puncture as part of a routine diagnostic work-up.…”

Section: Participantsmentioning

confidence: 71%

“…The test ACE-R-CZ is a 20-30 min more detailed examination of cognitive functions than the Mini-Mental State Examination (MMSE) (ref. [22][23][24][25][26][27][28] ). MMSE scores were derived from the ACE-R-CZ.…”

Section: Participantsmentioning

confidence: 99%

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

Fialová¹,

Bartoš²,

Švarcová³

2017

BIOMED PAP

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Aims. The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins between neurodegeneration and neuroinflammation. Methods. CSF and serum levels of neurofilament light subunits (NFL) and neurofilament heavy subunits (NFH) as well as CSF levels of total tau (t-tau) and phosphorylated tau (p-tau) proteins were determined using ELISA in 20 Alzheimer's disease patients (AD group), 13 patients with other dementias (OD group), 17 patients with inflammatory aseptic neuro-infections (IP), and 20 aged-matched cognitively normal elderly persons (NC group). Results. The ratio CSF p-tau/t-tau was significantly higher in the NC group than that in the AD or OD groups (P<0.0005 for each group). The CSF NFH/p-tau and CSF NFL/p-tau ratios were significantly lower in AD patients than OD patients (P≤0.003). Serum and CSF NFL and CSF NFH levels were significantly higher in OD patients than AD patients (P≤0.03).The lowest values of the CSF NFL/NFH ratio were found in the IP group and they significantly differed from those in normal controls (P<0.0001) and any dementia group (IP vs. AD P<0.0001; IP vs. OD P=0.03). Conclusion. CSF tau proteins and their index differentiated between AD or OD patients and cognitively normal subjects, while CSF levels of neurofilaments expressed as their index seem to contribute to the discrimination between patients with neuroinflammation and normal controls or AD patients.

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The Mini-Mental State Examination: Czech Norms and Cutoffs for Mild Dementia and Mild Cognitive Impairment due to Alzheimer's Disease

Cited by 35 publications

References 25 publications

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons

Prevalence, Recognition, and Treatment of Dementia in Assisted Living Facilities

Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation

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