The millennium bugs — the need for and development of new antibacterials

Bax, Richard; Mullan, N. A.; Verhoef, J.

doi:10.1016/s0924-8579(00)00189-8

Cited by 133 publications

(102 citation statements)

References 19 publications

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“…These peptides generally act by forming pores in microbial membranes or otherwise disrupting membrane integrity (82), which is facilitated by their amphiphilic structure. This mode of action is unlikely to lead to the development of resistance (9,58), although it must be noted that this presumption is debatable (10). Recently, cationic antimicrobial peptides have been reported to be involved in many aspects of innate host defenses, associated with processes such as acute inflammation (25).…”

mentioning

confidence: 99%

Antimicrobial Peptides from Marine Invertebrates

Tincu

Taylor

2004

Antimicrob Agents Chemother

293

135

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mentioning

confidence: 99%

Antimicrobial Peptides from Marine Invertebrates

Tincu

Taylor

2004

Antimicrob Agents Chemother

293

135

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“…In the past few decades, drug-resistant human pathogenic microbes have been developed (Bax, Mullan & Verhuef, 2000;Cohen, 1992;Finch, Greenwood, Norrby & Whitley, 2003;Neu, 1998 andStruelens, 1992). The widespread and misuse of antibiotics in humans and animals (Ritter & Wong, 2001;Alekshun & Levy, 2007) may directly contribute to this resistance, which in fact, represents a major medical challenge (Setti, Quattrocchio & Micetich, 1997).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Biological Evaluation and 2D-QSAR Studies of Novel 6-Oxo-Pyridine-3-Carboxamide Derivatives as Antimicrobial and Antifungal Agents

El‐Sehrawi¹,

Soliman²,

Khalifa³

et al. 2015

IJC

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In this study twenty six novel derivatives of 6-oxo-pyridine-3-carboxamide were synthesized and evaluated as antibacterial and antifungal agents. Synthesis of the 2-amino-4-methyl-6-oxo-N,1-diphenyl-1,6-dihydropyridine-3-carboxamide 1 was carried out by reacting equimolar quantities of acetoacetanilide and cyanoacetanilide in ethanol using triethylamine as a catalyst. The results of the in vitro antimicrobial evaluation showed that, the 6-oxo-N,1-diphenyl-5-(p-tolyldiazenyl)-1,6-dihydropyridine-3-carboxamide, 5c displayed broad-spectrum antibacterial activity which was equipotent to both Ampicillin and Gentamicin against the tested bacteria. Moreover, compounds 3a, 5c and 9b were equipotent to the reference drug, Amphotericin B, against Aspergillus fumigatus (MIC = 1.95µg/ml). 2D QSAR studies were carried out in order to correlate the observed activity to the binding mode of these compounds, in addition to their molecular properties that might be controlling their activities.

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“…The rapid emergence of multidrug resistant pathogenic bacteria has become a serious health threat worldwide (Bax et al, 2000). Microorganisms are developing resistance continuously in the past several decades, so there is urgent need to discover novel antibacterial agents that could combat the antibacterial resistance (Kunin 1993).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of di-2-ethylaniline phosphate screened by paper disc diffusion method

Banjara¹

2012

J. App. Pharm. Sci.

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Antibacterial activity di-2-ethylaniline phosphate was studied against four Gram negative bacteria at 100-10000 µg/ml concentration using the paper disc diffusion method. Results indicated that the test compound, di-2-ethylaniline phosphate has demonstrated significant antibacterial activity against all selected Gram negative bacteria. Di-2-ethylaniline phosphate was found to be effective against bacteria A at lowest concentration 100 µg/ml where the zone of inhibition was 9 mm diameter in size and largest zone 24 mm diameter formed at highest concentration 10000 µg/ml against bacteria D while bacteria B and C exhibited more resistance as compared to bacteria A and D. In conclusion di-2-ethylaniline phosphate exhibited an efficient antibacterial activity.

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The millennium bugs — the need for and development of new antibacterials

Cited by 133 publications

References 19 publications

Antimicrobial Peptides from Marine Invertebrates

Antimicrobial Peptides from Marine Invertebrates

Synthesis, Biological Evaluation and 2D-QSAR Studies of Novel 6-Oxo-Pyridine-3-Carboxamide Derivatives as Antimicrobial and Antifungal Agents

Antibacterial activity of di-2-ethylaniline phosphate screened by paper disc diffusion method

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