The Midlife Women’s Health Study – a study protocol of a longitudinal prospective study on predictors of menopausal hot flashes

Ziv‐Gal, Ayelet; Smith, Rebecca L.; Gallicchio, Lisa; Miller, S.; Zacur, Howard A.; Flaws, Jodi A.

doi:10.1186/s40695-017-0024-8

Cited by 29 publications

(36 citation statements)

References 55 publications

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“…All studies were approved by the University of Illinois, Urbana-Champaign Institutional Review Board (UIUC IRB protocol number 06741). The Midlife Women's Health Study is a longitudinal study on risk factors for hot flashes in women who are residents of the Baltimore metropolitan region, which includes Baltimore city and several of its surrounding counties (15). This parent study, named the Midlife Women's Health Study, was specifically designed to test the hypothesis that obesity is associated with hot flashes through mechanisms that involve early ovarian failure, altered estradiol levels, and selected genetic polymorphisms in steroidogenic enzymes and steroid hormone receptors.…”

Section: Participants and Samplesmentioning

confidence: 99%

“…We measured the circulating FFAs increased in susceptible individuals in an independent cohort including 37 nonobese and 63 overweight and obese (BMI > 25) postmenopausal women from the "Midlife Women's Health Study." Plasma samples were collected from cancer-free women, 2-3 years after onset of menopause (15). Whole metabolite profiling was conducted for these 100 samples ( Fig.…”

Section: Validating Plasma Factors Associated With Obesitymentioning

confidence: 99%

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Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling

et al. 2019

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Obesity is a risk factor for postmenopausal estrogen receptor alpha (ERa)-positive (ER þ) breast cancer. Molecular mechanisms underlying factors from plasma that contribute to this risk and how these mechanisms affect ERa signaling have yet to be elucidated. To identify such mechanisms, we performed whole metabolite and protein profiling in plasma samples from women at high risk for breast cancer, which led us to focus on factors that were differentially present in plasma of obese versus nonobese postmenopausal women. These studies, combined with in vitro assays, identified free fatty acids (FFA) as circulating plasma factors that correlated with increased proliferation and aggressiveness in ER þ breast cancer cells. FFAs activated both the ERa and mTOR pathways and rewired metabolism in breast cancer cells. Pathway preferential estrogen-1 (PaPE-1), which targets ERa and mTOR sig-naling, was able to block changes induced by FFA and was more effective in the presence of FFA. Collectively, these data suggest a role for obesity-associated gene and metabolic rewiring in providing new targetable vulnerabilities for ER þ breast cancer in postmenopausal women. Furthermore, they provide a basis for preclinical and clinical trials where the impact of agents that target ERa and mTOR signaling cross-talk would be tested to prevent ER þ breast cancers in obese postmenopausal women. Significance: These findings show that obesity-associated changes in certain blood metabolites rewire metabolic programs in cancer cells, influence mammary epithelial cell tumorigenicity and aggressiveness, and increase breast cancer risk.

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Section: Participants and Samplesmentioning

confidence: 99%

Section: Validating Plasma Factors Associated With Obesitymentioning

confidence: 99%

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling

et al. 2019

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“…The sample population used was from the Midlife Women's Health Study (MWHS), which has been described in detail elsewhere [12]. The MWHS is a longitudinal study that was conducted between 2006 and 2015 to understand the relationship between risk factors and hot ashes in midlife women.…”

Section: Study Samplementioning

confidence: 99%

Racial Differences in Lifestyle, Demographic, and Health Factors Associated with Quality of Life (QoL) in Midlife Women

Smith

Cardoso-Mendoza

Flaws

et al. 2020

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Background Quality of Life (QoL) is a major indicator of an individual’s overall health. Only a few studies have examined the racial differences between QoL, and risk factors associated with health, demographics, and lifestyle in midlife women. Thus, the purpose of our study is to determine racial differences in QoL in menopausal women due to lifestyle, demographic, and health related factors. Methods A stratified ordinal logistic regression model was applied to self-reported questionnaire data from the Midlife Women's Health Study (MWHS) to determine risk factors associated with QoL differences between white and black women during the menopausal transition. Results In multivariate models, our results showed black women who had 3 or 4 comorbidities (moderate) were about 4 times as likely to have higher QoL compared to women who had 0 to 2 comorbidities (95% CI: 1.65,10.78). However, the number of comorbidities was not significantly associated with QoL in white women in univariate or multivariate analysis. Further, BMI, education, and income were not significant factors in QoL in black women but were in white women. Conclusions Overall, our results illustrate that differences in health, demographic, and lifestyle factors are associated with QoL during menopause. Also, we suggest that future studies evaluate stratified models between racial groups to determine race-specific risk factors related to quality of life.

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“…The sample population included women from the Midlife Women's Health Study (MWHS), which has been described in detail elsewhere [14]. The MWHS is a longitudinal study that was conducted between 2006 and 2015 to understand the relationship between risk factors and hot ashes in midlife women.…”

Section: Study Samplementioning

confidence: 99%

“…Lifestyle factors or modi able factors that can greatly in uence health included were BMI, smoking status, and drinking status [16]. BMI was calculated from measured height and weight then characterized as normal/underweight( < 25 kg/m2), overweight (between 25-29 kg/m2), or obese (>30 kg/m2) [14]. Drinking status was determined by responses to the following question, "In the last 12 months have you had at least 12 drinks of any kind of alcoholic beverage?…”

Section: Study Variablesmentioning

confidence: 99%

Racial Differences in Lifestyle, Demographic, and Health Factors Associated with Quality of Life (QoL) in Midlife Women

Smith

Cardoso-Mendoza

Flaws

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Previously, quality of life (Qol) has been defined as an individual’s evaluation of a satisfactory life as a whole (i.e. physically, mentally, psychologically, and socially). Only a few studies have examined the racial differences between QoL, and risk factors associated with health, demographics, and lifestyle in midlife women. Thus, the purpose of our study is to determine racial differences in QoL in menopausal women due to lifestyle, demographic, and health related risk factors. A stratified ordinal logistic regression model was applied to self-reported questionnaire data from the Midlife Women's Health Study (MWHS) to determine risk factors associated with QoL differences between White and Black women during the menopausal transition. In multivariate models, our results showed Black women who had 3 or 4 comorbidities (moderate) were about 4 times as likely to have higher QoL compared to women who had 0 to 2 comorbidities (95% CI: 1.65,10.78). However, the number of comorbidities was not significantly associated with QoL in White women in univariate or multivariate analysis. Further, BMI and income were not significant factors in QoL in Black women but were in White women. Overall, our results illustrate that differences in health, demographic, and lifestyle factors are associated with QoL during menopause. Also, we suggest that future studies evaluate stratified models between racial groups to determine race-specific risk factors related to quality of life.

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The Midlife Women’s Health Study – a study protocol of a longitudinal prospective study on predictors of menopausal hot flashes

Cited by 29 publications

References 55 publications

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling

Racial Differences in Lifestyle, Demographic, and Health Factors Associated with Quality of Life (QoL) in Midlife Women

Racial Differences in Lifestyle, Demographic, and Health Factors Associated with Quality of Life (QoL) in Midlife Women

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