The midlands trial of empirical amiodarone versus electrophysiology-guided interventions and implantable cardioverter-defibrillators (MAVERIC): a multi-centre prospective randomised clinical trial on the secondary prevention of sudden cardiac death

Abstract

Prospective selection of patients to receive the ICD by EP study did not improve survival compared with empirical amiodarone therapy among survivors of VT, VF or SCD, whereas ICD implantation improved survival regardless of allocated treatment. On this basis, routine EP study has no role in the management of such patients, who should be offered empirical ICD therapy according to the results of other secondary prevention ICD trials.

Resource Loss Predicts Depression and Anxiety Among Patients Treated With an Implantable Cardioverter Defibrillator

“…Clinical trials have demonstrated the efficacy of the implantable cardioverter defibrillator (ICD) in reducing mortality resulting from sudden cardiac death as well as its superiority over antiarrhythmic therapy in primary and secondary prevention (2)(3)(4)(5). Consequently, ICDs have become a common medical treatment for life-threatening arrhythmias.…”

Analysis of Implantable Defibrillator Longevity Under Clinical Circumstances: Implications for Device Selection

“…Large randomized clinical trials have demonstrated that implantable cardioverter‐defibrillator (ICD) therapy improves survival in patients at risk for life‐threatening ventricular arrhythmias 1–10 . Due to the expanded indications for ICD therapy, the number of implantations on account of a primary prevention indication has increased 11–14,19–21 .…”

“…Large randomized clinical trials have demonstrated that implantable cardioverter-defibrillator (ICD) therapy improves survival in patients at risk for life-threatening ventricular arrhythmias. [1][2][3][4][5][6][7][8][9][10] Due to the expanded indications for ICD therapy, the number of implantations on account of a primary prevention indication has increased. [11][12][13][14][19][20][21] It is expected that primary prevention patients will survive their ICD service time, and so will need one or more replacements.…”

Delayed and Indirect Effects of Antiarrhythmic Drugs in Reducing Sudden Cardiac Death

“…ICD therapy extended the survival by a mean of 4.4 months over a period of 6 years. The Defibrillator Versus b-blockers for Unexplained Death in Thailand (DEBUT) [72] and the Midlands Trial of Empirical Amiodarone Versus Electrophysiology-Guided Interventions and Implantable CardioverterDefibrillators (MAVERIC) [73] also demonstrated the benefit of the ICD over b-blockers and amiodarone, respectively. future science group…”