The Midbrain and Audiogenic Seizures

Contribution of metabotropic glutamate receptors to synaptic transmissions of inferior colliculus neurons

“…The ICC is thought to be an integration centre, and it receives excitatory and inhibitory inputs from various structures of the lower auditory brainstem (Kelly and Caspary, 2005). The balanced excitation and inhibition in the ICC is critical not only for appropriate processing of incoming auditory information but also for preventing pathological activity, such as audiogenic seizures (Faingold, 2005). To maintain the balance between excitation and inhibition in an ICC neuron, presynaptic mGluR II and GABAB receptors on both the glutamatergic and GABAergic terminals may work synergically, or act in different extent.…”

Electrophysiological characteristics of neurons in the dorsal cortex of the inferior colliculus

“…It has been demonstrated that GABAergic inhibition can modulate the firing rate, tuning curve, duration tuning and binaural response of auditory neurons Yang et al, 1992;Casseday et al, 1994;Park and Pollak, 1994;Klug et al, 1995;Fuzessery and Hall, 1996;Burger and Pollak, 1998;Koch and Grothe, 1998;Ingham and McAlpine, 2005;Wu, 2005). In addition, GABA-mediated inhibition is also related with audiogenic seizure genesis (Faingold, 2002(Faingold, , 2005. GABA mediates its inhibitory actions via distinct receptor systems including ionotropic GABAA and metabotropic GABAB receptors (Bowery, 1993;Bettler et al, 2004;Takeda et al, 2004).…”