The microspheres/hydrogels scaffolds based on the proteins, nucleic acids, or polysaccharides composite as carriers for tissue repair: A review

Li, Xian; Wu, Xinlin

doi:10.1016/j.ijbiomac.2023.126611

Cited by 8 publications

(3 citation statements)

References 162 publications

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“…Moreover, after in situ alkalization treatment, the drug loading of HMS‐ROP was further improved by 2.7 times and 1.3 times higher than that of MS‐ROP·HCl and HMS‐ROP·HCl, respectively; this was significantly higher than most of the hydrogel microspheres (less than 10%) reported in the literature. [ 38 , 39 ] Notably, HMS‐ROP is the microsphere carrier with the highest drug‐loading capacity for local anesthesia. [ 16 , 28 , 40 ] In summary, using microfluidic technology and in situ alkalization, the HMS‐ROP drug‐loading system could achieve high drug‐loading capacity.…”

Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

Li,

Chen,

Xue

et al. 2024

Advanced Science

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Peripheral nerve block is performed for precise pain control and lesser side effects after surgery by reducing opioid consumption. Injectable hydrogel delivery systems with high biosafety and moisture content have good clinical application prospects for local anesthetic delivery. However, how to achieve high drug loading and long‐term controlled release of water‐soluble narcotic drugs remains a big challenge. In this study, heterogeneous microspheres and an injectable gel‐matrix composite drug delivery system are designed in two steps. First, heterogeneous hydrogel microspheres loaded with ropivacaine (HMS‐ROP) are prepared using a microfluidic chip and in situ alkalization. An injectable self‐healing hydrogel matrix (Gel) is then prepared from modified carboxymethylcellulose (CMC‐ADH) and oxidized hyaluronic acid (OHA). A local anesthetic delivery system, Gel/HMS‐ROP/dexmedetomidine (DEX), with long‐term retention and drug release in vivo is prepared by combining HMS‐ROP and Gel/DEX. The drug loading of HMS‐ROP reached 41.1%, with a drug release time of over 160 h in vitro, and sensory and motor blockade times in vivo of 48 and 36 h, respectively. In summary, the sequential release and synergistic analgesic effects of the two anesthetics are realized using core‐shell microspheres, DEX, and an injectable gel, providing a promising strategy for long‐acting postoperative pain management.

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Section: Resultsmentioning

confidence: 99%

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

Li,

Chen,

Xue

et al. 2024

Advanced Science

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“…Their controlled release mechanism ensures a stable drug concentration within the joint, reducing the frequency of injections and maintaining consistent therapeutic effects [ 25 ]. Moreover, microspheres serve as carriers for various therapeutic agents, including growth factors, cytokines, and gene therapy vectors, enhancing tissue repair, modulating immune responses, and regulating inflammatory processes in the joint [ 26 ]. This comprehensive strategy holds considerable promise for arthritis treatment, allowing for the integration of multiple therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment

Cao,

Li,

Zhang

et al. 2024

J Nanobiotechnol

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Background and aims Osteoarthritis (OA) is a prevalent degenerative joint disorder, marked by the progressive degeneration of joint cartilage, synovial inflammation, and subchondral bone hyperplasia. The synovial tissue plays a pivotal role in cartilage regulation. Exosomes (EXOs), small membrane-bound vesicles released by cells into the extracellular space, are crucial in mediating intercellular communication and facilitating the exchange of information between tissues. Our study aimed to devise a hydrogel microsphere infused with SOD3-enriched exosomes (S-EXOs) to protect cartilage and introduce a novel, effective approach for OA treatment. Materials and methods We analyzed single-cell sequencing data from 4247 cells obtained from the GEO database. Techniques such as PCR, Western Blot, immunofluorescence (IF), and assays to measure oxidative stress levels were employed to validate the cartilage-protective properties of the identified key protein, SOD3. In vivo, OA mice received intra-articular injections of S-EXOs bearing hydrogel microspheres, and the effectiveness was assessed using safranine O (S.O) staining and IF. Results Single-cell sequencing data analysis suggested that the synovium influences cartilage via the exocrine release of SOD3. Our findings revealed that purified S-EXOs enhanced antioxidant capacity of chondrocytes, and maintained extracellular matrix metabolism stability. The S-EXO group showed a significant reduction in mitoROS and ROS levels by 164.2% (P < 0.0001) and 142.7% (P < 0.0001), respectively, compared to the IL-1β group. Furthermore, the S-EXO group exhibited increased COL II and ACAN levels, with increments of 2.1-fold (P < 0.0001) and 3.1-fold (P < 0.0001), respectively, over the IL-1β group. Additionally, the S-EXO group showed a decrease in MMP13 and ADAMTS5 protein expression by 42.3% (P < 0.0001) and 44.4% (P < 0.0001), respectively. It was found that S-EXO-containing hydrogel microspheres could effectively deliver SOD3 to cartilage and significantly mitigate OA progression. The OARSI score in the S-EXO microsphere group markedly decreased (P < 0.0001) compared to the OA group. Conclusion The study demonstrated that the S-EXOs secreted by synovial fibroblasts exert a protective effect on chondrocytes, and microspheres laden with S-EXOs offer a promising therapeutic alternative for OA treatment.

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“…Thanks to their properties (biocompatibility, swelling in aqueous environment, sensitivity to external environment stimuli), it has been possible to obtain commercial products in various fields, as in the case of the biomedical and pharmaceutical fields. Hydrogels have been studied to develop contact lenses, wound dressing, drug and gene delivery, tissue engineering, cell scaffolds, tissue repair, immunotherapies, and vaccines [ 3 , 4 , 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Cardio and Vascular Tissue Repair and Regeneration

Motta,

Soccio,

Guidotti

et al. 2024

Gels

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Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i.e., aneurysmal dilation, with high risk of rupture. Aneurysms of the intracranial arteries (IAs) are more commonly seen in young adults, whereas those of the abdominal aorta (AAA) are predominantly seen in the elderly. IAs, unpredictably, can undergo rupture and cause life-threatening hemorrhage, while AAAs can result in rupture, internal bleeding and high mortality rate. In this clinical context, hydrogels, three-dimensional networks of water-seizing polymers, have emerged as promising biomaterials for cardiovascular tissue repair or protection due to their biocompatibility, tunable properties, and ability to encapsulate and release bioactive molecules. This review provides an overview of the current state of research on the use of hydrogels as an innovative platform to promote cardiovascular-specific tissue repair in MI and functional recovery or protection in aneurysmal dilation.

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The microspheres/hydrogels scaffolds based on the proteins, nucleic acids, or polysaccharides composite as carriers for tissue repair: A review

Cited by 8 publications

References 162 publications

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

Injectable Hydrogel Delivery System with High Drug Loading for Prolonging Local Anesthesia

Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment

Hydrogels for Cardio and Vascular Tissue Repair and Regeneration

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