Abstract:Repeated microsphere injections are extensively employed for measurements of uteroplacental blood flows in experimental animals. However, this technique has not been systematically validated in pregnancy. In the present series of experiments the effects of three consecutive microsphere injections on central haemodynamics and regional blood flows were studied in 43 late pregnant guinea-pigs. In group A (n = 13) experiments were carried out in the awake chronically catheterized animal. In group B (n = 8) animals… Show more
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