The microRNA-Processing Enzyme Dicer Is Essential for Thyroid Function

Frezzetti, Daniela; Reale, Carla; Calı̀, Gaetano; Nitsch, Lucio; Fagman, Henrik; Nilsson, Ola; Scarfò, Marzia; Vita, Gabriella De; Lauro, Roberto Di

doi:10.1371/journal.pone.0027648

Cited by 51 publications

(44 citation statements)

References 33 publications

(38 reference statements)

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“…In addition, Dicer is an important ribonuclease involved in the biogenesis of miRNAs (154). Frezzetti et al reported that the development of the thyroid gland was not affected by the absence of Dicer through using thyrocyte-specific Dicer knockout mice, but Dicer knockout resulted in severe hypothyroidism (155). In addition, Dicer inactivation also increased the expressions of Tg and decreased the expressions of cell adhesion proteins in the thyroid cells, such as Cdh16 and Cdh1 (155).…”

Section: Epigenetics In Aitdmentioning

confidence: 99%

“…Frezzetti et al reported that the development of the thyroid gland was not affected by the absence of Dicer through using thyrocyte-specific Dicer knockout mice, but Dicer knockout resulted in severe hypothyroidism (155). In addition, Dicer inactivation also increased the expressions of Tg and decreased the expressions of cell adhesion proteins in the thyroid cells, such as Cdh16 and Cdh1 (155). Saeki et al found that AITD patients had lower expression of Dicer and DROSHA compared with healthy controls, and DICER rs1057035 and DROSHA rs644236 were obviously associated with susceptibility to GD (156).…”

Section: Epigenetics In Aitdmentioning

confidence: 99%

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The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases

et al. 2017

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Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves’ disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Epigenetics have been considered to exert key roles in integrating those genetic and environmental factors, and epigenetic modifications caused by environmental factors may drive genetically susceptibility individuals to develop AITD. Recent studies on the epigenetics of AITD have provided some novel insights into the pathogenesis of AITD. The aim of this review is to provide an overview of recent advances in the epigenetic mechanisms of AITD, such as DNA methylation, histone modifications, and non-coding RNAs. This review highlights the key roles of epigenetics in the pathogenesis of AITD and potential clinical utility. However, the epigenetic roles in AITD are still not fully elucidated, and more researches are needed to provide further deeper insights into the roles of epigenetics in AITD and to uncover new therapeutic targets. Although there are many studies assessing the epigenetic modifications in AITD patients, the clinical utility of epigenetics in AITD remains poorly defined. More studies are needed to identify the underlying epigenetic modifications that can contribute to accurate diagnosis of AITD, adequate choice of treatment approach, and precise prediction of treatment outcomes.

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Section: Epigenetics In Aitdmentioning

confidence: 99%

Section: Epigenetics In Aitdmentioning

confidence: 99%

The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases

et al. 2017

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“…After that, they are exported by exportin-5 to the cytoplasm Marini et al, 2011). In the cytoplasm, pre-miRNAs undergo further processing by endonuclease Dicer and become mature miRNAs Frezzetti et al, 2011a;Marini et al, 2011). Mature miRNAs can bind to the 3' untranslated region (UTR) of mRNAs, resulting in blockage of translation or mRNA degradation depending on the degree of complementarity between miRNA and mRNA (Ambros, 2004;Bartel, 2004).…”

Section: Introductionmentioning

confidence: 99%

Deregulation of microRNA expression in thyroid tumors

Yuan

Yang

Zheng

2014

J. Zhejiang Univ. Sci. B

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MicroRNAs (miRNAs or miRs) are endogenous non-coding RNAs that negatively regulate gene expression by binding to the 3' non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expression profiles, single nucleotide polymorphism (SNP) in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.

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“…For example, DICER was found to play an essential role in thyroid function (20), hepatocyte survival, metabolism, tumor suppression (21) and in tumorigenesis (22). RNASEN (DROSHA) regulates cell proliferation and affects survival in esophageal cancer patients (23).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA biogenesis and cellular proliferation

Lenkala¹,

Gamazon²,

LaCroix³

et al. 2015

Translational Research

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Given the fundamental roles of microRNAs (miRNAs) in physiological, developmental and pathological processes, we hypothesized that genes involved in miRNA biogenesis contribute to human complex traits. For thirteen such genes, we evaluated the relationship between transcription and two classes of complex traits, namely cellular growth and sensitivity to various chemotherapeutic agents in a set of lymphoblastoid cell lines. We found a highly significant correlation between protein argonaute-2 (AGO2) expression and cellular growth rate (Bonferroni-adjusted p < 0.05), and report additional miRNA biogenesis genes with suggestive associations with either cellular growth rate or chemotherapeutic sensitivity. AGO2 expression was found to be correlated with multiple drug sensitivity phenotypes. Furthermore, small interfering RNA (siRNA) knockdown of AGO2 resulted in cellular growth inhibition in an ovarian cancer cell line (OVCAR3), supporting the role of this miRNA biogenesis gene in cell proliferation in cancer cells. Expression quantitative trait loci mapping indicated that genetic variation (in the form of both single nucleotide polymorphisms (SNPs) and copy number variations (CNVs)) that may regulate the expression of AGO2 can have downstream effects on cellular-growth-dependent complex phenotypes.

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The microRNA-Processing Enzyme Dicer Is Essential for Thyroid Function

Cited by 51 publications

References 33 publications

The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases

The Emerging Role of Epigenetics in Autoimmune Thyroid Diseases

Deregulation of microRNA expression in thyroid tumors

MicroRNA biogenesis and cellular proliferation

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