The MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing: The Functional Significance of the miR-195/497 Cluster

Iwamoto, Toshihiko; Seki, Naohiko; Yoshino, Hirofumi; Chiyomaru, Takeshi; Yamasaki, Takahiro; Hidaka, Hideo; Yonezawa, Tomokazu; Nohata, Nijiro; Kinoshita, Takashi; Nakagawa, Masayuki; Enokida, Hideki

doi:10.1371/journal.pone.0084311

Cited by 135 publications

(148 citation statements)

References 50 publications

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“…Generally however, the myomiRs expressed in normal tissue are found downregulated in tumors when analysed by both qRTPCR and by sequencing platforms. Significantly, another deep sequencing profile of expressed miRs in bladder cancer [128] revealed a different myomiR expression profile to the above deep sequencing study [127] , yet confirmed the pattern of myomiR expression detected previously by the same group using microarray and qRTPCR techniques [93] ( Table 3). Overall, these various platform comparisons suggest the need to reevaluate the genomewide miR expression profiles of different cancers by use of deep sequencing and then to confirm findings using independent molecular methods.…”

Section: Cancer and Downregulated Myomirssupporting

confidence: 86%

“…Several large cohort studies have examined the changes in expressed miR networks in a variety of cancers. Navon et al [95] , Hart et al [125] , Han et al [127] , Itesako et al [128] and Volinia et al [145] noted that the downregulated expression of the miR-133/-1/-206 genes is associated with a variety of solid tissue cancers, with numerous other miRs also having highly significant oncogenic roles in particular cancer types. In sum, the downregulation of the various myomiRs contributes significantly to the upregulation of oncogenic proteins linked to regulation of cell cycle progression in solid tumors, sarcomas and carcinomas.…”

Section: Other Pleiotropic Pathwaysmentioning

confidence: 99%

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Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Mitchelson¹

2015

WJBC

136

132

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MicroRNAs are small non-coding RNAs that participate in different biological processes, providing subtle combinational regulation of cellular pathways, often by regulating components of signalling pathways. Aberrant expression of miRNAs is an important factor in the development and progression of disease. The canonical myomiRs (miR-1, -133 and -206) are central to the development and health of mammalian skeletal and cardiac muscles, but new findings show they have regulatory roles in the development of other mammalian non-muscle tissues, including nerve, brain structures, adipose and some specialised immunological cells. Moreover, the deregulation of myomiR expression is associated with a variety of different cancers, where typically they have tumor suppressor functions, although examples of an oncogenic role illustrate their diverse function in different cell environments. This review examines the involvement of the related myomiRs at the crossroads between cell development/ tissue regeneration/tissue inflammation responses, and cancer development. Core tip: The roles of the canonical muscle-associated microRNAs are reviewed, including microRNA families miR-1 and miR-133, and single miR-206, which are collectively known as the "myomiRs". The myomiRs act at the crossroads of the molecular regulation of muscle cells, linking between pathways for cell differentiation, development and maintenance, but also potentiate aberrant cell growth in numerous non-muscle cancers. Typically myomiRs are downregulated in cancers, but some myomiRs are upregulated in a few cancers, yet each dysregulation event advances tumor progression. The review examines normal and disease-linked molecular changes associated with the myomiRs, and collates the extensive literature into accessible tables. REVIEW

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Section: Cancer and Downregulated Myomirssupporting

confidence: 86%

Section: Other Pleiotropic Pathwaysmentioning

confidence: 99%

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Mitchelson¹

2015

WJBC

136

132

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“…For example, it is upregulated in metastatic melanoma (10) and some cases of lung cancer (16), and hepatocellular carcinoma (17). By contrast, it is preferentially downregulated in breast cancer (18), gastric cancer (17,19), colorectal cancer (20)(21)(22), and bladder cancer (23,24). However, inconsistent and inconclusive results have been reported concerning the expression and function of miR-195 in PCa (17,25).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1

et al. 2016

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Abstract. Aberrant deregulation of is associated with tumorigenesis and the development of cancer. However, its expression and function in prostate cancer (PCa) remain to be elucidated. In the present study, we found that miR-195 expression levels were decreased in human PCa samples and were correlated with patient prognosis. miR-195 overexpression inhibited cell proliferation, cell cycle progression and tumorigenesis via directly targeting HMGA1. Downregulation of HMGA1 expression had an effect similar to miR-195 in the PCa cells. In clinical specimens, HMGA1 was overexpressed in castration-resistant prostate cancer when compared with its levels in benign prostate hyperplasia and androgen-dependent prostate cancer, and its expression levels were inversely correlated with overall survival and biochemical relapse-free survival. In summary, our study suggests that miR-195 functions as a tumor-suppressor gene by downregulating HMGA1 and can be used as a potential target in the treatment of PCa.

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“…41 It was observed that downregulation of miR-195 and miR-497 is related to bladder cancer progression and metastasis. 42 In a bladder cancer animal model study, it was observed that miR-582 delivery was connected with the inhibition of tumor growth and metastasis. 43 …”

Section: -9mentioning

confidence: 99%

Clinical and pathological implications of miRNA in bladder cancer

Braicu¹,

Cojocneanu²,

Chira³

et al. 2015

IJN

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MicroRNAs (miRNAs) are small, noncoding RNA species with a length of 20–22 nucleotides that are recognized as essential regulators of relevant molecular mechanisms, including carcinogenesis. Current investigations show that miRNAs are detectable not only in different tissue types but also in a wide range of biological fluids, either free or trapped in circulating microvesicles. miRNAs were proven to be involved in cell communication, both in pathological and physiological processes. Evaluation of the global expression patterns of miRNAs provides key opportunities with important practical applications, taking into account that they modulate essential biological processes such as epithelial to mesenchymal transition, which is a mechanism relevant in bladder cancer. miRNAs collected from biological specimens can furnish valuable evidence with regard to bladder cancer oncogenesis, as they also have been linked to clinical outcomes in urothelial carcinoma. Therefore, a single miRNA or a signature of multiple miRNAs may improve risk stratification of patients and may supplement the histological diagnosis of urological tumors, particularly for bladder cancer.

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The MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing: The Functional Significance of the miR-195/497 Cluster

Cited by 135 publications

References 50 publications

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease

Downregulation of miR-195 promotes prostate cancer progression by targeting HMGA1

Clinical and pathological implications of miRNA in bladder cancer

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