The microRNA-29 family in cartilage homeostasis and osteoarthritis

Le, Linh; Swingler, T.E.; Crowe, Natalie; Vincent, Tonia L.; Barter, M.J.; Donell, Simon; Delany, Anne M.; Dalmay, Tamás; Young, David A.; Clark, Ian M.

doi:10.1007/s00109-015-1374-z

Cited by 111 publications

(139 citation statements)

References 57 publications

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“…A previous study on early posttraumatic OA identified a dysregulation of 34 miRNAs in whole joint extracts obtained from mice at 1 week post‐DMM . In comparison, we identified 122 dysregulated miRNAs at the same time point, only 4 of which were common to both studies (miR‐136‐5p, miR‐210‐3p, miR‐214‐5p, and miR‐379‐5p).…”

Section: Discussionmentioning

confidence: 54%

Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End‐Stage Human Disease

Kung

Ravi

Rowley

et al. 2018

Arthritis & Rheumatology

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Section: Discussionmentioning

confidence: 54%

Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End‐Stage Human Disease

Kung

Ravi

Rowley

et al. 2018

Arthritis & Rheumatology

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“…For example, the miRNA-29 family targets NF-kB, Smad, and WNT [145]. A number of miRNAs that are upregulated in OA chondrocytes are also important regulators of chondrogenesis.…”

Section: Mirna Regulation Of Chondrogenesis and Cartilage Homeostasismentioning

confidence: 99%

The Role of MicroRNAs and Their Targets in Osteoarthritis

Sondag

Haqqi

2016

Curr Rheumatol Rep

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MicroRNA regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Recent studies have focused on specific microRNAs that are differentially expressed in case of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationship of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify selected microRNAs that are differentially expressed in osteoarthritic tissue, but have unidentified targets and functions in the disease pathogenesis. Lastly, we highlight the potential use of microRNAs for therapeutic purposes, and also point to certain remedies that regulate microRNA expression.

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“…MicroRNAs are small noncoding RNAs with lengths of 21-25 nucleotides, which regulate gene expression at the posttranscriptional level [32][33][34]. Aberrant expressions of microRNAs have been found in various types of cancers [35].…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429

et al. 2016

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Long noncoding RNAs (lncRNAs) have been reported to play pivotal roles in a variety of cancers. However, lncRNAs involved in hepatocellular carcinoma (HCC) initiation and progression remain largely unclear. In this study, we identified an lncRNA gradually increased during hepatocarcinogenesis (lncRNA-GIHCG) using publicly available microarray data. Our results further revealed that GIHCG is upregulated in HCC tissues in comparison with adjacent non-tumor tissues. High GIHCG expression is correlated with large tumor size, microvascular invasion, advanced BCLC stage, and poor survival of HCC patients. Functional experiments showed that GIHCG promotes HCC cells proliferation, migration, and invasion in vitro, and promotes xenografts growth and metastasis in vivo. Mechanistically, we demonstrated that GIHCG physically associates with EZH2 and the promoter of miR-200b/a/429, recruits EZH2 and DNMT1 to the miR-200b/a/429 promoter regions, upregulates histone H3K27 trimethylation and DNA methylation levels on the miR-200b/a/429 promoter, and dramatically silences miR-200b/a/429 expression. Furthermore, the biological functions of GIHCG on HCC are dependent on the silencing of miR-200b/a/429. Collectively, our results demonstrated the roles and functional mechanisms of GIHCG in HCC, and indicated GIHCG may act as a prognostic biomarker and potential therapeutic target for HCC. KEY MESSAGE: lncRNA-GIHCG is upregulated in HCC and associated with poor survival of patients. GIHCG significantly promotes tumor growth and metastasis of HCC. GIHCG physically associates with EZH2. GIHCG upregulates H3K27me3 and DNA methylation levels on the miR-200b/a/429 promoter. GIHCG epigenetically silences miR-200b/a/429 expression.

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The microRNA-29 family in cartilage homeostasis and osteoarthritis

Cited by 111 publications

References 57 publications

Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End‐Stage Human Disease

Cartilage MicroRNA Dysregulation During the Onset and Progression of Mouse Osteoarthritis Is Independent of Aggrecanolysis and Overlaps With Candidates From End‐Stage Human Disease

The Role of MicroRNAs and Their Targets in Osteoarthritis

Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429

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