The microRNA-200 family: still much to discover

Senfter, Daniel; Madlener, Sibylle; Krupitza, Georg; Mader, Robert M.

doi:10.1515/bmc-2016-0020

Cited by 69 publications

(62 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The up-regulation of miR-200 family members, and the subsequent accelerated epithelial-mesenchymal transition (EMT), intravasation, and increased motility are well-characterized phenomena in various cancers in vitro [13]. In prostate cancer, miR-200a, with a 5.17-fold increase when set against benign tissue, was one of the most obviously up-regulated miRNAs included in a recent meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival

et al. 2018

View full text Add to dashboard Cite

Objectives: Protein levels of the transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein 1 (Keap1) have been proposed as prognostic factors in pancreatic ductal adenocarcinomas (PDACs). These cellular redox-state-regulating enzymes are targeted by several microRNAs, including miR-93 and miR-200a. Methods: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. Expression levels were separately measured in malignant cells and adjacent benign cells. Results: Keap1 and Nrf2 mRNA expression levels in cancer cells were lower than in adjacent benign tissue (Wilcoxon’s test; p = 0.0015 and p = 0.000032, respectively). Conversely, miR-93 expression was higher in cancer cells than in adjacent benign tissue (p = 0.00082). Low levels of miR-93 and miR-200a in cancer cells were associated with poorer differentiation (p = 0.004 and p = 0.002, respectively). In univariate survival analysis, benign-tissue levels of miR-200a above the median predicted better relapse-free survival (RFS) (p = 0.045). Conclusions: High miR-93 and miR-200a levels in cancer cells of PDAC were associated with better differentiation, and miR-200a expression in benign tissue with excellent RFS. Keap1 and Nrf2 mRNA levels showed prominent down-regulation in cancerous versus benign tissue, but they were not associated with disease aggressiveness or outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Expression levels of miRNAs are profoundly altered during carcinogenesis, but alterations in miRNA profiles may also initiate tumour growth and metastasis [12, 13]. Some miRNAs are considered to be “redoxmiRs,” as they have an essential influence on redox-state regulation [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Based on the structure of these members, they are also divided into two functional groups, the difference between them is about the third nucleotide of seed sequences. Functional group 1 is miR-200a/141, whose seed sequence is AACACUG, the other is miR-200b/c/429, whose seed sequence is AAUACUG [43] (Fig. 7).…”

Section: Regulatory Function Of Mir-200 Family On Their Target Genes mentioning

confidence: 99%

The roles of microRNA families in hepatic fibrosis

Jiang

Wan

et al. 2017

Cell Biosci

View full text Add to dashboard Cite

When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists of several miRNAs which have the potential for synergistic regulation of these signaling pathways. However, it is poor to understand the roles of miRNA family as a whole in hepatic fibrosis. Increasing studies have suggested several miRNA families are related with activation of hepatic stellate cells and hepatic fibrosis through cooperatively regulating certain signaling pathways. During the process of hepatic fibrosis, miR-29 family primarily induces cell apoptosis by modulating phosphatidylinositol 3-kinase/AKT signaling pathway and regulates extracellular matrix accumulation. miR-34 family promotes the progression of hepatic fibrosis by inducing activation of hepatic stellate cells, while miR-378 family suppresses the process in Glis dependent manner. miR-15 family mainly promotes cell proliferation and induces apoptosis. The miR-199 family and miR-200 family are responsible for extracellular matrix deposition and the release of pro-fibrotic cytokines. These miRNA family members play pro-fibrotic or anti-fibrotic roles by targeting genes collectively or respectively which involve in hepatic fibrosis related signaling pathways and hepatic stellate cell activation. Thus, good understandings of molecular mechanisms which are based on miRNA families may provide new ideas for the molecular targeted therapy of hepatic fibrosis in the future.

show abstract

“…19 However, it is still not clear how miRNAs control NPC progression and metastasis. 20 The miR-200 family of miRNAs is comprised of five members. In humans, miR-200a, miR-200b, and miR-429 are located on chromosome 1p36.33, while miR-200c and miR-141 are located on chromosome 12p13.31.…”

Section: Introductionmentioning

confidence: 99%